Potential of Garra rufa as a novel high-temperature resistant model fish: a review on current and future approaches

Zoological Letters, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 27, 2025

Abstract Garra rufa , commonly known as the “doctor fish”, is a freshwater cyprinid native to warm regions of Middle East. Since late twentieth century, it has been widely utilized in spas for alternative therapeutics and fish pedicures (or manicures) dermatological diseases such psoriasis eczema. Owing its unique characteristics, there growing interest exploring various applications G. . This review provides comprehensive summary phylogenetic position, ecology, biological breeding methods insights into use therapeutic fish. Notably, ability thrive high-temperature environments exceeding 37 °C distinguishes from other cyprinids suggests potential model human diseases, infectious cancer xenograft models high-throughput drug screening. The ongoing genome sequencing project aims elucidate mechanisms underlying tolerance offers valuable genomic resources. These efforts have resulted significant advances aquaculture, species conservation, biomedical research.

Language: Английский

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Insights into Virus-Host Interactions: Lessons from Caenorhabditis elegans-Orsay Virus Model

Current Medical Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

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Is Zebrafish a Good Model for the Alpha‐Gal Syndrome?

The FASEB Journal, Journal Year: 2025, Volume and Issue: 39(9)

Published: May 2, 2025

ABSTRACT The alpha‐Gal syndrome (AGS) is an underdiagnosed tick‐borne allergy characterized by both immediate and delayed IgE‐mediated anaphylactic reactions to the galactose‐alpha‐1,3‐galactose (alpha‐Gal) epitope. Common manifestations include gastrointestinal, cutaneous, respiratory symptoms appearing 2–6 h after consumption of mammalian meat or derived products. Zebrafish ( Danio rerio ) are emerging as essential animal models in biomedical studies, due their anatomical, genetic, physiological similarities humans, with significant applications toxicology, behavioral research, oncology, inflammation studies. mechanisms associated AGS sustained studies humanized α1,3GalT‐KO C57BL/6 mouse Mus musculus zebrafish for production anti‐alpha‐Gal antibodies response tick saliva, development allergic animals sensitized protein extracts following consumption, identification immune mechanisms. a skewed type 2 response, triggering Toll‐Like receptor (TLR) signaling pathways, IL‐4 production, humoral activity. These results support use rather than single one more comprehensive characterization AGS‐associated In this study, we focused on model biomedicine research immunity, infectious, diseases, particular emphasis candidate therapeutic interventions. Based insights from multiple concluded that suitable studying AGS, considering addressed limitations combination model.

Language: Английский

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Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12008 - 12008

Published: Nov. 8, 2024

The zebrafish (

Language: Английский

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Pioneering use of human intestinal enteroids to prevent foodborne transmission of human norovirus

Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104843 - 104843

Published: Dec. 1, 2024

Language: Английский

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