Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(2), P. 277 - 277
Published: Jan. 14, 2025
Vitamin
D
offers
numerous
under-recognized
health
benefits
beyond
its
well-known
role
in
musculoskeletal
health.
It
is
vital
for
extra-renal
tissues,
prenatal
health,
brain
function,
immunity,
pregnancy,
cancer
prevention,
and
cardiovascular
Existing
guidelines
issued
by
governmental
organizations
are
bone-centric
largely
overlook
the
abovementioned
extra-skeletal
optimal
thresholds
vitamin
D.
In
addition,
they
rely
on
randomized
controlled
trials
(RCTs),
which
seldom
show
due
to
high
baseline
25-hydroxyvitamin
[25(OH)D]
concentrations,
moderate
supplementation
doses,
flawed
study
designs.
This
review
emphasizes
findings
from
prospective
cohort
studies
showing
that
higher
25(OH)D
concentrations
reduce
risks
of
major
diseases
mortality,
including
pregnancy
birth
outcomes.
Serum
>
30
ng/mL
(75
nmol/L)
significantly
lower
disease
mortality
compared
<20
ng/mL.
With
25%
U.S.
population
60%
Central
Europeans
having
levels
ng/mL,
should
be
raised
above
achievable
through
daily
with
2000
IU/day
(50
mcg/day)
D3,
prevent
deaths.
Furthermore,
a
dose
between
4000
6000
IU
D3
achieve
serum
40
70
would
provide
greater
protection
against
many
adverse
Future
recommendations
integrate
observational
well-designed
RCTs
improve
public
personalized
care.
Language: Английский
Emotional reactions towards vaccination during the emergence of the omicron variant: Insights from twitter analysis in South Africa
Machine Learning with Applications,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100644 - 100644
Published: March 1, 2025
Language: Английский
Vitamin D Deficiency Meets Hill’s Criteria for Causation in SARS-CoV-2 Susceptibility, Complications, and Mortality: A Systematic Review
Nutrients,
Journal Year:
2025,
Volume and Issue:
17(3), P. 599 - 599
Published: Feb. 6, 2025
Clinical
trials
consistently
demonstrate
an
inverse
correlation
between
serum
25-hydroxyvitamin
D
[25(OH)D;
calcifediol]
levels
and
the
risk
of
symptomatic
SARS-CoV-2
disease,
complications,
mortality.
This
systematic
review
(SR),
guided
by
Bradford
Hill’s
causality
criteria,
analyzed
294
peer-reviewed
manuscripts
published
December
2019
November
2024,
focusing
on
plausibility,
consistency,
biological
gradient.
Evidence
confirms
that
cholecalciferol
(D3)
calcifediol
significantly
reduce
hospitalizations,
mortality,
with
optimal
effects
above
50
ng/mL.
While
vitamin
requires
3–4
days
to
act,
shows
within
24
h.
Among
329
trials,
only
11
(3%)
showed
no
benefit
due
flawed
designs.
At
USD
2/patient,
D3
supplementation
is
far
cheaper
than
hospitalization
costs
more
effective
standard
interventions.
SR
establishes
a
strong
relationship
25(OH)D
vulnerability,
meeting
criteria.
Vitamin
infections,
deaths
~50%,
outperforming
all
patented,
FDA-approved
COVID-19
therapies.
With
over
300
confirming
these
findings,
waiting
for
further
studies
unnecessary
before
incorporating
them
into
clinical
protocols.
Health
agencies
scientific
societies
must
recognize
significance
results
incorporate
prophylaxis
early
treatment
protocols
similar
viral
infections.
Promoting
safe
sun
exposure
adequate
communities
maintain
40
ng/mL
(therapeutic
range:
40–80
ng/mL)
strengthens
immune
systems,
reduces
hospitalizations
deaths,
lowers
healthcare
costs.
When
exceed
70
ng/mL,
taking
K2
(100
µg/day
or
800
µg/week)
alongside
helps
direct
any
excess
calcium
bones.
The
recommended
dosage
(approximately
IU/kg
body
weight
non-obese
adult)
50–100
cost-effective
disease
prevention,
ensuring
health
outcomes.
Language: Английский
Unveiling the Interplay—Vitamin D and ACE-2 Molecular Interactions in Mitigating Complications and Deaths from SARS-CoV-2
Biology,
Journal Year:
2024,
Volume and Issue:
13(10), P. 831 - 831
Published: Oct. 16, 2024
The
interaction
of
the
SARS-CoV-2
spike
protein
with
membrane-bound
angiotensin-converting
enzyme-2
(ACE-2)
receptors
in
epithelial
cells
facilitates
viral
entry
into
human
cells.
Despite
this,
ACE-2
exerts
significant
protective
effects
against
coronaviruses
by
neutralizing
viruses
circulation
and
mitigating
inflammation.
While
reduces
expression,
vitamin
D
increases
it,
counteracting
virus's
harmful
effects.
Vitamin
D's
beneficial
actions
are
mediated
through
complex
molecular
mechanisms
involving
innate
adaptive
immune
systems.
Meanwhile,
status
[25(OH)D
concentration]
is
inversely
correlated
severity,
complications,
mortality
rates
from
COVID-19.
This
study
explores
which
inhibits
replication,
including
suppression
transcription
enzymes,
reduced
inflammation
oxidative
stress,
increased
expression
antibodies
antimicrobial
peptides.
Both
hypovitaminosis
elevate
renin
levels,
rate-limiting
step
renin-angiotensin-aldosterone
system
(RAS);
it
ACE-1
but
expression.
imbalance
leads
to
elevated
levels
pro-inflammatory,
pro-coagulatory,
vasoconstricting
peptide
angiotensin-II
(Ang-II),
leading
widespread
It
also
causes
membrane
permeability,
allowing
fluid
infiltrate
soft
tissues,
lungs,
vascular
system.
In
contrast,
sufficient
suppress
reducing
RAS
activity,
lowering
ACE-1,
increasing
levels.
cleaves
Ang-II
generate
Ang
Language: Английский