Farmasi Cerdas: Era Baru Penemuan Obat dengan AI dan Big Data

MEDICINUS, Journal Year: 2025, Volume and Issue: 38(1), P. 27 - 36

Published: Jan. 1, 2025

Proses penemuan obat telah memasuki era baru dengan munculnya kecerdasan buatan (artificial intelligence/AI) dan big data. Pendekatan tradisional, panjang, mahal kini dilengkapi alternatif yang efisien berkat kemampuan AI untuk menganalisis pola kompleks data mengintegrasikan kumpulan berskala besar. Artikel ini membahas peran teknologi tersebut dalam mempercepat inovasi farmasi, mengulas aplikasi praktis, menyoroti tantangan serta prospek masa depan. Dengan data, industri farmasi dapat memajukan pengobatan presisi memperdalam pemahaman kita tentang biologi penyakit.

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Antimicrobial Resistance: Linking Molecular Mechanisms to Public Health Impact

SLAS DISCOVERY, Journal Year: 2025, Volume and Issue: unknown, P. 100232 - 100232

Published: April 1, 2025

Antimicrobial resistance (AMR) develops into a worldwide health emergency through genetic and biochemical adaptations which enable microorganisms to resist antimicrobial treatment. β-lactamases (blaNDM, blaKPC) efflux pumps (MexAB-OprM) working with mobile elements facilitate fast proliferation of multidrug-resistant (MDR) exttreme drug-resistant (XDR) phenotypes thus creating major concerns for healthcare systems community as well the agricultural sector. The review dissimilarly unifies molecular pathways public implications study epidemiological data monitoring approaches innovative therapeutic solutions. Previous studies separating their attention between genetics clinical outcomes have been combined our approach delivers an all-encompassing analysis AMR. report investigates mechanisms feature enzymatic degradation pump overexpression together target modification horizontal gene transfer because these factors represent important contributors present-day AMR developments. This effects on hospital environments where it affects pathogens including MRSA, carbapenem-resistant Klebsiella pneumoniae, Pseudomonas aeruginosa. document explores modern management methods that comprise WHO GLASS surveillance three strategies such CRISPR-modified genome editing bacteriophage treatments along peptides artificial intelligence diagnostic tools. resolution needs complete scientific global operational alongside state-of-the-art approaches. Worldwide infection burden requires both enhanced prevention procedures next-generation reduce cases effectively.

Language: Английский

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Streptomyces from desert environments: a treasure trove of next-generation natural compounds

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 3

Published: Sept. 12, 2024

Language: Английский

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