Exploring WNT pathway dysregulation in serrated colorectal cancer for improved diagnostic and therapeutic strategies

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Background Serrated colorectal cancer (SCC) is a rare and aggressive subtype of cancer. Identifying SCC crucial due to its high mortality rate limited therapeutic options. Traditional methods identify BRAF hotspot mutations MLH1 methylation are insufficient in clinical practice. This study aims explore the WNT pathway alterations CRC develop WNT-derived subtyping model patients by using multi-OMICs data. Methods We included multi-omics data 1751 from TCGA GEO databases, single-cell transcriptome 33 normal tissues SMC cohort. The comprehensive process incorporated unsupervised clustering, enrichment analysis, statistical analysis. Results In this study, we investigated integrating both bulk into framework. demonstrated significant heterogeneity more stable genomic structure. These findings support development that accurately identifies across different cohorts. addition, also presented distinct immune microenvironment characterized CD8 + T cell exhaustion. Finally, utilized drug perturbation potential targets for severe subtype. Conclusion developed method canonical CRC, which enhances molecular understanding provides strategies. Our suggest may benefit HSP90 inhibitor NVP-AUY922, highlighting as targeted therapy.

Language: Английский

TRIB3 knockdown increases the sensitivity of clear cell renal cell carcinoma to sunitinib by inducing ferroptosis

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111421 - 111421

Published: Sept. 17, 2024

Language: Английский

Syringin as a novel therapeutic agent for renal cell carcinoma by targeting EGFR/PI3K/Akt pathway and enhancing sunitinib efficacy

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 123, P. 106556 - 106556

Published: Nov. 13, 2024

Language: Английский