Extracellular vesicles secreted by leukemic cells as mediators of dysregulated hematopoiesis: acute myeloid leukemia as a case in point

Expert Review of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Acute myeloid leukemia (AML) cells exhibit a profound capacity for resistance to conventional chemotherapeutic agents, posing substantial challenge existing therapeutic paradigms. Interestingly, this happens in the face of luxuriant proliferation leukemic blasts peripheral blood. This paradox concurrent proliferative activity and cellular quiescence underscores complex biological phenomenon that is intricately mediated by AML-derived Extracellular vesicles (EVs). An extensive literature review search was done on Pubmed/Scopus/Web Sciences databases identify studies published between 2013 2024 elucidating demonstrating effect EVs, Microvesicles (MVs) Exosomes (Exos) regulating normal dysregulated bone marrow (BM) niche. The delves into understanding molecular mechanisms underlying dual behavior AML - quiescence, with special focus role EVs their subtypes viz. Exos MVs establishing discrete BM microenvironment subversive chemotherapy. It offers novel perspective intricate interplay microenvironment, implications interventions targeting persistence drug resistance.

Language: Английский

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Hematopoietic Stem Cells of Bone Marrow and Their Total RNA in Rat Liver Regeneration

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(7), P. 3782 - 3782

Published: March 30, 2025

Hematopoietic stem cells derived from bone marrow are known to induce tissue repair. Their mechanisms liver regeneration not clear and may have numerous adverse effects. We compared the regenerative potential of intact hematopoietic (iHSCs), their total RNA, apoptotic (aHSCs) in damage. Male Wistar rats (n = 40 per group) experienced a 75% resection received single intraperitoneal injections saline (control group), iHSCs, aHSCs, or RNA iHSCs. recorded animal survival, mass, blood markers cell lysis function (albumin, aminotransferases, alkaline phosphatase), histological features: mitotic index expression for proliferation apoptosis (caspase-9, caspase-3, Ki-67). assessed survival with log-rank test used Wilcoxon t tests other parameters. Animals all HSC- RNA-treated groups survived until end experiment full marker recovery (p 0.037). The mass enlarged mostly after RNA. Mitotic peaked group lower but earlier increase aHSC group, Ki-67 was highest (all differences were significant p values ˂ 0.05). found aHSCs iHSC be most efficient reparation. Total HSCs is preferred further studies.

Language: Английский

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Emerging nanostructure-based strategies for breast cancer therapy: innovations, challenges, and future directions

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: April 30, 2025

Language: Английский

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Mesenchymal stem cell-derived exosomes: a novel therapeutic frontier in hematological disorders

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(6)

Published: May 6, 2025

Language: Английский

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