Green synthesis of Nickel oxide nanoparticles using Lagerstroemia speciosa, Bombax ceiba, and Piper chaba extracts and evaluating their potential antioxidant, antidiabetic and antibacterial properties

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42953 - e42953

Published: Feb. 1, 2025

Language: Английский

---

Phytochemical Isolation and Antimicrobial, Thrombolytic, Anti-inflammatory, Analgesic, and Antidiarrheal Activities from the Shell of Commonly Available Citrus reticulata Blanco: Multifaceted Role of Polymethoxyflavones

Nutrition and Metabolic Insights, Journal Year: 2025, Volume and Issue: 18

Published: April 1, 2025

Fruit wastes are becoming popular as treasures for drug discovery in different classes of therapeutics. This research aimed to investigate the phytochemicals and potential bioactivities, such antimicrobial, thrombolytic, anti-inflammatory, analgesic, antidiarrheal properties commonly available mandarin orange ( Citrus reticulata Blanco) peel through experimental computational techniques. Extensive chromatographic 1 H-NMR spectroscopic analysis was employed isolate four purified compounds, which were characterized tangeretin (A), nobiletin (B), limonin (C), β-sitosterol (D). Furthermore, GC-MS/MS detected over 90 compounds with a notable number polymethoxyflavones, including (29.04%), (15.55%), artemetin (8.1%), 6-demethoxytangeretin (1.28%), sinensetin (0.95%), demethylnobiletin (0.14%), pebrellin (0.10%), salvigenin (0.04%). Dichloromethane soluble fraction (DCMSF) exerted highest antimicrobial potency Candia albicans against (20 mm zone inhibition) disk diffusion assay method. The aqueous (AQSF) exhibited 34.71% 48.14% inhibition hypotonic solution-induced heat-induced hemolysis membrane stabilizing assay. Similarly, AQSF anti-thrombotic property 32.57% clot lysis. investigated 3 doses methanolic extracts (100, 200, 400 mg/kg body weight) statistically significant vivo central analgesic effects tail-flicking method time-dependent manner. Moreover, all efficacy inhibiting acetic acid-induced abdominal writhing castor oil-induced diarrheal episodes mouse models. molecular docking studies corroborated existing vitro findings by demonstrating better or comparable binding affinities toward respective receptors favorable pharmacokinetic toxicological profiles. present indicate that C. is rich source microbial infections, thrombosis, inflammation, pain, diarrhea. Nonetheless, comprehensive phytochemical screening imperative identify additional bioactive evaluate their pharmacological several chronic health conditions, grounded traditional uses current evidence.

Language: Английский

---

Unveiling phytochemicals and antioxidant, cytotoxic, anti-thrombotic, anti-inflammatory, and antibacterial activities from the leaves of Dalbergia stipulacea (Roxb.)

Pharmacological Research - Natural Products, Journal Year: 2024, Volume and Issue: unknown, P. 100126 - 100126

Published: Nov. 1, 2024

Language: Английский

---

Phytochemical Analysis and Antidiarrheal Activity of Stem Bark Decoctions of Pentadesma butyracea Sabine (Clusiaceae)

Molecules, Journal Year: 2024, Volume and Issue: 29(23), P. 5789 - 5789

Published: Dec. 7, 2024

Pentadesma butyracea is a medicinal plant of which bark decoctions are used in traditional medicine for the treatment diarrhea symptoms Gabon. The aim present work was to perform phytochemical and pharmacological analyses P. bark. In principal approach, spectrophotometric were quantify phenolic compounds, followed by liquid chromatography coupled mass spectrometry analysis that allowed identification flavanone–flavone dimers as main metabolites. Pharmacological showed absence toxicity, thus confirming safety use this decoction medicine. antioxidant activity demonstrated depend on their contents. stem barks harvested during rainy season also induced dose-dependent relaxation isolated ileum fragments from Wistar rats. addition, antidiarrheal investigated against castor oil-induced diarrhea. oral administration different concentrations led decrease wet stools, indicating an effect at doses used. These results encourage deepening bio-guided research order propose standard medical treatments.

Language: Английский

---

Protodioscin exerts antagonistic analgesic and antidiarrheal properties through the cyclooxygenase and µ-opioid receptor interaction pathways

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Protodioscin (PRO), a natural steroidal saponin, shows potential for treating pain and diarrhea due to its anti-inflammatory analgesic properties. The study aims investigate the antidiarrheal effects of PRO, comparing efficacy with diclofenac sodium (DFS) loperamide (LOP), using in vivo silico methods. Analgesic activity was evaluated acetic acid-induced writhing test, were assessed via castor oil-induced in mice. Mice divided into groups receiving PRO (2.5 10 mg/kg, p.o.), DFS (25 LOP (3 or combinations. Molecular docking studies conducted on COX-1, COX-2 enzymes, Mu-opioid receptor (MOR), toxicity predictions performed safety profiling. In results demonstrated that significantly reduced dose-dependent manner. at p.o. showed comparable p.o.) both models. revealed had stronger binding affinities COX-1 (‒10.0 kcal/mol), (‒9.6 kcal/mol) enzymes MOR (‒7.7 compared standard drugs. Toxicity indicated moderate similar DFS. exhibits significant activities LOP, making it promising alternative managing diarrhea. Further clinical trials pharmacokinetics profile are examine needed use long-term safety.

Language: Английский

---

Indian Shot (Canna Indica L). Leaves Provide Valuable Insights into the Management of Inflammation and Other Associated Disorders Offering Health Benefits

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 10943 - 10989

Published: Dec. 1, 2024

Throughout history, plants have played a crucial role in advancing medicinal treatments by providing diverse range of compounds for the development innovative therapies.

Language: Английский

---