Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107607 - 107607

Published: Jan. 1, 2025

Obesity is a global epidemic often associated with serious medical complications such as diabetes, hypertension and metabolic dysfunction-associated steatohepatitis. Considering the multifactorial nature of these diseases, medicinal plants could be valuable therapeutic strategy their phytoconstituents interact multiple relevant biological targets. In this context, Ilex paraguariensis emerges potential alternative to treat obesity diseases since several studies have demonstrated its anti-inflammatory, anti-obesity anti-diabetic effects. We present comprehensive complete non-clinical investigation efficacy, safety putative mechanisms action standardized aqueous extract I. (TI-076). also describe scalable preparation TI-076 demonstrate long-term stability. exhibits stability major constituents are well absorbed orally in mice rats. The five vivo proofs concept revealed that reduced obesity, hyperglycaemia, blood pressure, liver fat accumulation, levels serum insulin, leptin cholesterol, food intake, inflammation increased GLP-1 levels. through which acts seem involve modulation genes (Il1b, Nlrp3, Pparα Pparγ), white adipose metabolism (Cartpt, Mgll, Ramp3, Faah, Cck, Clps, damage fibrosis (Creb1, Col1a1 Col3a1). Finally, did not CYP3A4 proved safe. These findings strongly suggest holds great for clinical trials aimed at developing safe phytomedicine treating related diseases.

Language: Английский

Transforming Medical Education Through Intelligent Tools: A Bibliometric Exploration of Digital Anatomy Teaching

Education Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 346 - 346

Published: March 11, 2025

The teaching of human anatomy is experiencing significant transformation. Particularly in recent years, incorporating new digital technologies has drastically changed the approach to education. Our bibliometric study aims investigate trends and issues from 2004 2024 related technology teaching. publication trend field steadily increased over peaking 2022 declining 2023. Despite limited statistics for 2024, we do not project an exponential increase publications. Co-citation analysis identified notable references that significantly influenced field, emphasizing modernization through innovative methodologies. Leading a portion global collaboration, United States promoted robust multilateral partnerships. Co-occurrence word highlighted merging current with student-centered learning approaches, reflecting shift towards more interactive immersive experiences. Thematic map distinct research areas emerging or themes. topic last five years revealed persistent interest terms like “palmar” “carpal”, as well “cone beam computed tomography”, “augmented reality”, “virtual reality”. sector constant transformation, presenting scenario where integrating traditional methods could enhance medical students’ comprehension anatomy. On other hand, it also anticipated challenges ensuring equal access cutting-edge technology, providing sufficient training academic staff, addressing ethical issues.

Language: Английский