Inhibition Mechanism of Mulberry Prenylated Flavonoids Sanggenone D/Kuwanon G Against α-Glucosidase and the Regulation of Glucose via GLUT4 Pathway DOI Open Access

Erwen Wu,

Yanqing Zhu,

Qingyi Wei

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1539 - 1539

Published: April 30, 2025

Background: Inhibition of α-glucosidase activity is recognized as an effective strategy for managing type 2 diabetes. Methods: The inhibitory mechanisms two kinds mulberry flavonoids, namely sanggenone D and kuwanon G, on were investigated the hypoglycemic pathways explored in current study. Results: outcomes indicate that (IC50: 4.51 × 10−5 mol/L) G 3.83 inhibited by non-competition/anti-competition mixed inhibition competitive inhibition, respectively. Moreover, secondary structure was altered static quenching exhibited a decrease α-helix β-antiparallel content, increase β-sheet content. Furthermore, interaction forces between D/kuwanon hydrophobic interactions hydrogen bonds, evidenced molecular docking. binding affinity, stability, energy aligned with results IC50. Notably, cyclization resulted number phenolic hydroxyl groups thus reduction formation which ultimately diminished affinity to α-glucosidase. In addition, Western blot analysis further indicated regulated glucose metabolism activating GLUT4 pathway. Conclusions: provided useful reference application functional components.

Language: Английский

Mechanistic study of α-mangostin derivatives as potent α-glucosidase inhibitors DOI
Kamonpan Sanachai, Supakarn Chamni, Bodee Nutho

et al.

Molecular Diversity, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

Citations

0
Inhibition Mechanism of Mulberry Prenylated Flavonoids Sanggenone D/Kuwanon G Against α-Glucosidase and the Regulation of Glucose via GLUT4 Pathway DOI Open Access

Erwen Wu,

Yanqing Zhu,

Qingyi Wei

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(9), P. 1539 - 1539

Published: April 30, 2025

Background: Inhibition of α-glucosidase activity is recognized as an effective strategy for managing type 2 diabetes. Methods: The inhibitory mechanisms two kinds mulberry flavonoids, namely sanggenone D and kuwanon G, on were investigated the hypoglycemic pathways explored in current study. Results: outcomes indicate that (IC50: 4.51 × 10−5 mol/L) G 3.83 inhibited by non-competition/anti-competition mixed inhibition competitive inhibition, respectively. Moreover, secondary structure was altered static quenching exhibited a decrease α-helix β-antiparallel content, increase β-sheet content. Furthermore, interaction forces between D/kuwanon hydrophobic interactions hydrogen bonds, evidenced molecular docking. binding affinity, stability, energy aligned with results IC50. Notably, cyclization resulted number phenolic hydroxyl groups thus reduction formation which ultimately diminished affinity to α-glucosidase. In addition, Western blot analysis further indicated regulated glucose metabolism activating GLUT4 pathway. Conclusions: provided useful reference application functional components.

Language: Английский

Citations

0