Revealing culturable fungal microbiome communities from the Arabian Peninsula desert representing a unique source of biochemicals for drug discovery and biotechnology DOI Creative Commons
Walaa K. Mousa,

Najwa Alramadan,

Rose Ghemrawi

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 1527 - 1527

Published: Dec. 17, 2024

Background Microbes living at extremes evolve unique survival strategies to adapt challenging environmental conditions. Among these is their distinctive metabolic potential and ability produce specialized metabolites enabling them compete for limited resources defend against predators. These have significant in pharmaceutical industrial applications, particularly the development of drugs biochemicals. Objectives This study aimed investigate culturable fungal communities associated with four desert plants surrounding soils Arabian Peninsula identify bioactive properties. Methods A total 12 distinct species were isolated from soils. Each plant hosted a set fungi, demonstrating diversity desert-adapted communities. Biological activities extracts evaluated through various assays, including antimicrobial, antifungal, anticancer, antioxidant Results Panicum turgidum harbors most diverse community, dominated by genera such as Mucor, Aspergillus, Colletotrichum, Alternaria, Chaetomium. Aspergillus comprise 33% isolates, followed Fusarium 16%. All exhibit activities, highest phenolic flavonoid content. Fungi P. turgidum, Mucor sp., Curvularia display potent activity Staphylococcus aureus, while Chaetomium sp. moderate inhibition Pseudomonas aeruginosa. Conclusion highlights importance exploring extremophilic microorganisms, those found ecosystems, they offer wealth compounds that could address current challenges drug discovery biotechnology.

Language: Английский

Revealing culturable fungal microbiome communities from the Arabian Peninsula desert representing a unique source of biochemicals for drug discovery and biotechnology DOI Creative Commons
Walaa K. Mousa,

Najwa Alramadan,

Rose Ghemrawi

et al.

F1000Research, Journal Year: 2024, Volume and Issue: 13, P. 1527 - 1527

Published: Dec. 17, 2024

Background Microbes living at extremes evolve unique survival strategies to adapt challenging environmental conditions. Among these is their distinctive metabolic potential and ability produce specialized metabolites enabling them compete for limited resources defend against predators. These have significant in pharmaceutical industrial applications, particularly the development of drugs biochemicals. Objectives This study aimed investigate culturable fungal communities associated with four desert plants surrounding soils Arabian Peninsula identify bioactive properties. Methods A total 12 distinct species were isolated from soils. Each plant hosted a set fungi, demonstrating diversity desert-adapted communities. Biological activities extracts evaluated through various assays, including antimicrobial, antifungal, anticancer, antioxidant Results Panicum turgidum harbors most diverse community, dominated by genera such as Mucor, Aspergillus, Colletotrichum, Alternaria, Chaetomium. Aspergillus comprise 33% isolates, followed Fusarium 16%. All exhibit activities, highest phenolic flavonoid content. Fungi P. turgidum, Mucor sp., Curvularia display potent activity Staphylococcus aureus, while Chaetomium sp. moderate inhibition Pseudomonas aeruginosa. Conclusion highlights importance exploring extremophilic microorganisms, those found ecosystems, they offer wealth compounds that could address current challenges drug discovery biotechnology.

Language: Английский

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