The role of tumor-associated macrophages in HPV induced cervical cancer DOI Creative Commons
Zeping Chen, Baofeng Zhao

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Human papillomavirus (HPV), a double-stranded DNA virus linked to various malignancies, poses significant global public health challenge. In cervical cancer, persistent infection with high-risk HPV genotypes, particularly HPV-16 and HPV-18, initiates immune evasion mechanisms within the tumor microenvironment. The polarization of tumor-associated macrophages (TAMs) from M1 M2 phenotypes promotes carcinogenesis, metastasis, therapeutic resistance via establishing an immunosuppressive This review provides comprehensive overview HPV-induced pathways, including MHC downregulation, T-cell impairment, regulatory T cell induction, cGAS-STING pathway inhibition. Furthermore, describe pivotal role TAMs in cancer progression, focusing on their phenotypic plasticity, pro-tumoral functions, potential as targets. By elucidating these cellular molecular dynamics, this aims support advanced research. Targeting TAM through immunotherapies nanomedicine-based strategies represents promising strategy for enhancing patient outcomes.

Language: Английский

Targeting autophagy to enhance chemotherapy and immunotherapy in oral cancer DOI Creative Commons
Xiaoli Zeng, Yue Chen, Jing Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Oral cancer is a highly malignant disease characterized by recurrence, metastasis, and poor prognosis. Autophagy, catabolic process induced under stress conditions, has been shown to play dual role in oral development therapy. Recent studies have identified that autophagy activation epithelial cells suppresses cell survival inhibiting key pathways such as the mammalian target of rapamycin (mTOR) mitogen-activated protein kinase (MAPK), while activating adenosine monophosphate-activated (AMPK) pathway. Inducing promotes degradation eukaryotic initiation factor 4E, thus reducing metastasis enhancing efficacy chemotherapy, radiotherapy, immunotherapy. Furthermore, induction can modulate tumor immune microenvironment enhance antitumor immunity. This review comprehensively summarizes relationship between cancer, focusing on its mechanisms therapeutic potential when combined with conventional treatments. While promising, precise clinical applications inducers therapy remain be elucidated, offering new directions for future research improve treatment outcomes reduce recurrence.

Language: Английский

Citations

1
Advancements in targeted and immunotherapy strategies for glioma: toward precision treatment DOI Creative Commons

Guangyuan Gong,

Lang Jiang,

Jing Zhou

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

In recent years, significant breakthroughs have been made in cancer therapy, particularly with the development of molecular targeted therapies and immunotherapies, owing to advances tumor biology immunology. High-grade gliomas (HGGs), characterized by their high malignancy, remain challenging treat despite standard treatment regimens, including surgery, radiotherapy, chemotherapy, treating fields (TTF). These provide limited efficacy, highlighting need for novel strategies. Molecular immunotherapy emerged as promising avenues improving outcomes high-grade gliomas. This review explores current status advancements immunotherapeutic approaches

Language: Английский

Citations

1
Progress in immune microenvironment, immunotherapy and prognostic biomarkers in pediatric osteosarcoma DOI Creative Commons
Lin Zhang,

Haoming Jiang,

Hongzhi Ma

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Pediatric osteosarcoma, the most prevalent primary malignant bone tumor in children, is marked by aggressive progression and a generally poor prognosis. Despite advances treatment, including multi-agent chemotherapy, survival rates remain suboptimal, with metastasis, particularly to lungs, contributing significantly mortality. The microenvironment plays crucial role osteosarcoma progression, immune cells such as tumor-associated macrophages T lymphocytes influencing behavior. immunosuppressive environment, dominated M2 macrophages, contributes evasion therapeutic outcomes, though recent findings suggest potential for reprogramming these enhance responses. This review provides comprehensive overview of landscape pediatric focus on their interactions within (TME). It examines impact checkpoints, genetic mutations, inflammatory pathways highlighting contribution disease advancement. Additionally, emerging immunotherapeutic strategies, checkpoint inhibitors, macrophage reprogramming, antibody-based therapies, are summarized detail, showcasing improve outcomes.

Language: Английский

Citations

1
Overcoming immune evasion with innovative multi-target approaches for glioblastoma DOI Creative Commons
Hai Su, Peng Yin, Yi‐Long Wu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 22, 2025

Glioblastoma (GBM) cells leverage complex endogenous and environmental regulatory mechanisms to drive proliferation, invasion, metastasis. Tumor immune evasion, facilitated by a multifactorial network, poses significant challenge effective therapy, as evidenced the limited clinical benefits of monotherapies, highlighting adaptive nature evasion. This review explores glioblastoma’s evasion mechanisms, role ICIs in tumor microenvironment, recent advancements, offering theoretical insights directions for monotherapy combination therapy glioblastoma management.

Language: Английский

Citations

1
Tumor microenvironment regulation by reactive oxygen species-mediated inflammasome activation DOI
Jeong‐Hoon Jang,

Do-Hee Kim,

Kyung‐Soo Chun

et al.

Archives of Pharmacal Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

1
Intracellular and extracellular activities of V-domain Ig-containing suppressor of T cell activation (VISTA) modulated by immunosuppressive factors of tumour microenvironment DOI Creative Commons

Maryam Abooali,

Stephanie Schlichtner, Lei Xi

et al.

Cancer Letters, Journal Year: 2025, Volume and Issue: unknown, P. 217581 - 217581

Published: Feb. 1, 2025

V-domain Ig-containing suppressor of T cell activation (VISTA) is a unique immune checkpoint protein, which was reported to display both receptor and ligand activities. However, the mechanisms regulation VISTA activity functions by factors tumour microenvironment (TME) remain unclear understanding these processes required in order develop successful personalised cancer immunotherapeutic strategies approaches. Here we report for very first time that interacts with another protein galectin-9 inside most likely facilitating its interaction TGF-β-activated kinase 1 (TAK1). This process protection lysosomes, crucial many types tissues. We found expression can be differentially controlled present TME, such as transforming growth factor beta type (TGF-β) hypoxia well other activating hypoxic signalling. confirmed involvement important pathways modulated TME influences different types. These networks include: TGF-β-Smad3 pathway, TAK1 (TGF-β-activated 1) or apoptosis signal-regulating (ASK1)-induced transcription 2 (ATF-2) signalling pathway. Based on this work determined five critical role controlling (modulating downregulating) expression.

Language: Английский

Citations

1
DET induces apoptosis and suppresses tumor invasion in glioma cells via PI3K/AKT pathway DOI Creative Commons
Rui Zhao, Mengran Wang,

Zeyu Wu

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 14

Published: Jan. 9, 2025

Gliomas, particularly glioblastomas (GBM), are highly aggressive with a poor prognosis and low survival rate. Currently, deoxyelephantopin (DET) has shown promising anti-inflammatory anti-tumor effects. Using clinical prognostic analysis, molecular docking, network pharmacology, this study aims to explore the primary targets signaling pathways identify novel GBM treatment approaches. PharmMapper, chemical structure of DET was examined for possible after being acquired from PubChem. GBM-related were obtained through multi-omics A protein-protein interaction (PPI) constructed using Cytoscape STRING, target binding evaluated docking. Enrichment analysis conducted Metascape. The effects on cell invasion, apoptosis, proliferation assessed in vitro assays, including Transwell, EDU, CCK8, flow cytometry. Western blot performed examine components PI3K/AKT pathway. Among sixty-four shared identified, JUN CCND1 most frequently observed. demonstrated that influenced MAPK pathways. In Transwell significantly inhibited invasive behavior glioma cells. further confirmed downregulation EGFR, JUN, PI3K/AKT. inhibits proliferation, apoptosis via modulating pathway, highlighting its potential as therapeutic strategy treatment.

Language: Английский

Citations

0
DAMPs prognostic signature predicts tumor immunotherapy, and identifies immunosuppressive mechanism of pannexin 1 channels in pancreatic ductal adenocarcinoma DOI Creative Commons

Qianxue Wu,

Qian Xiao, Xin Tang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 15, 2025

Damage-associated molecular patterns (DAMPs) induced by immunogenic cell death (ICD) may be useful for the immunotherapy to patients undergoing pancreatic ductal adenocarcinoma (PDAC). The aim of this study is predict prognosis and responsiveness PDAC using DAMPs-related genes. K-means analysis was used identify subtypes 175 cases. significance gene mutation immune status in different detected. LASSO regression construct a prognostic signature PDAC. Subsequently, vivo vitro experiments Bulk-RNA seq were verify effect hub pannexin 1 (PANX1) on Two clustered based expression levels DAMPs genes from patients. Besides, landscape up-regulated poor. In addition, we constructed that correlated with infiltration predicted or chemotherapy Mechanically, through sequencing experiments, found PANX1 promoted tumor progression regulation via ATP release active NOD1/NFκB signaling pathway Our silico analyses established classification system ICD-related PDAC, model efficacy immunotherapy. This will provide new perspective targeting molecule treatment

Language: Английский

Citations

0
New insights into the mechanisms of the immune microenvironment and immunotherapy in osteosarcoma DOI Creative Commons
Cong Luo,

Xiaoyun Min,

Danying Zhang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 17, 2025

Osteosarcoma, a malignant bone tumor primarily affecting adolescents, is highly invasive with poor prognosis. While surgery and chemotherapy have improved survival for localized cases, pulmonary metastasis significantly reduces to approximately 20%, highlighting the need novel treatments. Immunotherapy, which leverages immune system target osteosarcoma cells, shows promise. This review summarizes biological characteristics of osteosarcoma, mechanisms metastasis, microenvironment (TME). It involves recent immunotherapy advances, including monoclonal antibodies, vaccines, cell therapies, checkpoint inhibitors, oncolytic viruses, discusses combining these standard

Language: Английский

Citations

0
Disulfidptosis as a key regulator of glioblastoma progression and immune cell impairment DOI Creative Commons

Yifu Shu,

Jing Li

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 30, 2025

Background Glioblastoma, associated with poor prognosis and impaired immune function, shows potential interactions between newly identified disulfidptosis mechanisms T cell exhaustion, yet these remain understudied. Methods Key genes were using Lasso regression, followed by multivariate analysis to develop a prognostic model. Single-cell pseudotemporal explored T-cell exhaustion (Tex) signaling in differentiation. Immune infiltration was assessed via ssGSEA, while transwell assays immunofluorescence examined the effects of disulfidptosis-Tex on glioma behavior response. Results Eleven found critical for glioblastoma survival outcomes. This gene set underpinned model predicting patient prognosis. showed high activity endothelial cells. Memory populations linked genes. SMC4 inhibition reduced LN299 migration increased chemotherapy sensitivity, decreasing CD4 CD8 activation. Conclusions Disulfidptosis-Tex are pivotal progression interactions, offering new avenues improving anti-glioblastoma therapies through modulation exhaustion.

Language: Английский

Citations

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