Comprehensive utilization of black soldier fly (Hermetia illucens) larvae: extraction, recovery and characterization of peptide, chitin and melanin and scaling-up trial

Separation and Purification Technology, Journal Year: 2024, Volume and Issue: unknown, P. 131262 - 131262

Published: Dec. 1, 2024

Language: Английский

Lipid extract from Black Soldier Fly larvae: A high value excipient for solid lipid nanoparticles tailored to tackle atopic dermatitis

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124929 - 124929

Published: Nov. 9, 2024

Atopic dermatitis (AD) is a chronic inflammatory skin disorder with complex pathogenesis involving epidermal barrier dysfunction and aberrant lipid composition, particularly ceramides fatty acids (FA). Conventional management options, such as topical glucocorticoids (GC), often lead to adverse effects upon prolonged usage, prompting the exploration of alternative therapeutic strategies. The extract from Black Soldier Fly larvae (BSFL) biomass, holding rich blend FA, holds substantial potential novel ingredient tackle impairment. This study aimed achieve proof-of-concept validation innovative nanotechnology-based formulations tailored enhance AD. Specifically, solid nanoparticles (SLNs) BSFL were developed perform both carrier for dexamethasone (DEX), representative GC, repair adjuvants. Through systematic optimization using Box-Behnken Design, extract-based SLNs demonstrated favorable physicochemical properties application satisfactory stability over 2 months. Notably, these exhibited drug release kinetics, delivering total DEX payload within therapeutically relevant timeframe. Furthermore, nanocarriers showed ability permeate human keratinocytes without pronounced toxicity, suggesting their utility in enhancing delivery cellular uptake. Overall, findings suggest that promising natural sustainable development nanotechnology-driven approaches AD management, offering avenue addressing unmet needs this challenging dermatologic condition.

Language: Английский

Black soldier fly frass from seed waste of nitrogen-rich legumes – How long-term maturation affects the fertilizer properties?

Journal of Environmental Management, Journal Year: 2024, Volume and Issue: 373, P. 123752 - 123752

Published: Dec. 18, 2024

Language: Английский