Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study DOI Creative Commons
Jianjun Wang, Han Li,

Pei Yang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Although blood urea nitrogen and albumin alone are well-known clinical indicators, combining them as the nitrogen-to-albumin ratio (BAR) may provide additional prognostic information because they reflect complex interplay between renal function, nutritional status, systemic inflammation-all of which key factors in pathogenesis acute pancreatitis (AP). Therefore, objective this study was to investigate relationships BAR short- long-term all-cause mortality (ACM) patients with AP assess significance AP. This retrospective investigation utilized extracted from Medical Information Mart for Intensive Care-IV (MIMIC-IV, Version 2.2) database. calculated using BUN/ALB obtained first measurement within 24 h admission. R software used identify optimal threshold BAR. The Kaplan-Meier (K-M) analysis performed compare two groups. Multivariate Cox proportional hazards regression models restricted cubic splines (RCS) were evaluate association 14-day, 28-day, 90-day, 1-year ACM. receiver operating characteristic curves predictive ability, sensitivity, specificity, area under curve (AUC) patients. Subgroup illustrate reliability our findings. comprised a total 569 determined be 16.92. K-M indicated notable rise ACM higher (all log-rank p < 0.001). hazard revealed independent associations before after adjusting confounding variables at days 14, 28, 90, 1 year. RCS J-shaped correlations AUCs predicting year 73.23, 76.14, 73.49, 71.00%, respectively, superior those BUN, ALB, creatinine, Sequential Organ Failure Assessment, Acute Physiology Chronic Health Evaluation-II. analyses no significant interaction vast majority subgroups. revealed, time, unique value ICU-managed Higher levels associated

Language: Английский

Exploring the value of blood urea nitrogen-to-albumin ratio in patients with acute pancreatitis admitted to the intensive care unit: a retrospective cohort study DOI Creative Commons
Jianjun Wang, Han Li,

Pei Yang

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Although blood urea nitrogen and albumin alone are well-known clinical indicators, combining them as the nitrogen-to-albumin ratio (BAR) may provide additional prognostic information because they reflect complex interplay between renal function, nutritional status, systemic inflammation-all of which key factors in pathogenesis acute pancreatitis (AP). Therefore, objective this study was to investigate relationships BAR short- long-term all-cause mortality (ACM) patients with AP assess significance AP. This retrospective investigation utilized extracted from Medical Information Mart for Intensive Care-IV (MIMIC-IV, Version 2.2) database. calculated using BUN/ALB obtained first measurement within 24 h admission. R software used identify optimal threshold BAR. The Kaplan-Meier (K-M) analysis performed compare two groups. Multivariate Cox proportional hazards regression models restricted cubic splines (RCS) were evaluate association 14-day, 28-day, 90-day, 1-year ACM. receiver operating characteristic curves predictive ability, sensitivity, specificity, area under curve (AUC) patients. Subgroup illustrate reliability our findings. comprised a total 569 determined be 16.92. K-M indicated notable rise ACM higher (all log-rank p < 0.001). hazard revealed independent associations before after adjusting confounding variables at days 14, 28, 90, 1 year. RCS J-shaped correlations AUCs predicting year 73.23, 76.14, 73.49, 71.00%, respectively, superior those BUN, ALB, creatinine, Sequential Organ Failure Assessment, Acute Physiology Chronic Health Evaluation-II. analyses no significant interaction vast majority subgroups. revealed, time, unique value ICU-managed Higher levels associated

Language: Английский

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