Role of Ischemia/Reperfusion and Oxidative Stress in Shock State DOI Creative Commons

Yarielis Ivette Vázquez-Galán,

Sandra Guzmán-Silahua, Walter Ángel Trujillo-Rangel

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(11), P. 808 - 808

Published: May 30, 2025

Shock is a life-threatening condition characterized by inadequate tissue perfusion leading to systemic hypoxia and metabolic failure. Ischemia/reperfusion (I/R) injury exacerbates shock progression through oxidative stress immune dysregulation, contributing multi-organ dysfunction. This narrative review synthesizes current evidence on the interplay between I/R injury, stress, modulation in states. We analyze classification of shock, its progression, molecular pathways involved ischemic adaptation, inflammatory responses, injury. pathophysiology driven ischemia, triggering adaptive responses such as hypoxia-inducible factor (HIF) signaling reprogramming. However, prolonged leads mitochondrial dysfunction, increased reactive oxygen species (ROS) nitrogen (RNS) production, activation. The transition from response syndrome (SIRS) compensatory anti-inflammatory (CARS) contributes imbalance, further aggravating damage. Dysregulated checkpoint pathways, including CTLA-4 PD-1, fail suppress excessive inflammation, exacerbating exhaustion. intricate relationship ischemia/reperfusion dysregulation states highlights potential therapeutic targets. Strategies aimed at modulating redox homeostasis, controlling mitigating damage may improve patient outcomes. Future research should focus novel interventions that restore balance while preventing

Language: Английский

Bibliometric Analysis of Global Publications on Management, Trends, Energy, and the Innovation Impact of Green Hydrogen Production DOI Open Access
César Rodríguez-Aburto,

José Poma-García,

Jorge Alberto Montaño Pisfil

et al.

Sustainability, Journal Year: 2024, Volume and Issue: 16(24), P. 11048 - 11048

Published: Dec. 17, 2024

The aim of this bibliometric analysis was to evaluate the evolution scientific research in hydrogen, focusing on green hydrogen production, storage, and utilization. Articles from prominent databases were analyzed, revealing a strong emphasis sustainable technologies through keywords like “hydrogen production”, “green hydrogen”, “solar power generation”. Mature areas include production methods electrolysis, while emerging topics such as energy efficiency policy are gaining traction. most-cited papers, Energy Conversion Management International Journal Hydrogen Energy, cover techno-economic assessments case studies deploying technologies. Key findings highlight variability Levelized Cost (LCOH) across regions. Deep learning applications, including Fast Fourier Transform-based forecasting explainable AI models, transforming optimization, Life Cycle Assessment (LCA) emphasizes renewable energy’s role reducing carbon intensity resource consumption. Diverse strategies, fiscal incentives for wind use urban waste, underline importance local solutions. This reflects rapid growth research, driven by international collaboration innovations optimization. It is hoped that paper will help shed more light current future understanding hydrogen.

Language: Английский

Citations

3

Research hotspots and trends in the application of electroencephalography for assessment of disorders of consciousness: a bibliometric analysis DOI Creative Commons
Jiawen Chen, Yanhua Shi, Dong Zhao

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 27, 2025

Objective Disorders of consciousness (DoC) result from severe traumatic brain injury and hypoxia or ischemia tissues, leading to impaired perceptual abilities. Electroencephalography (EEG) is a non-invasive widely applicable technology used for assessing DoC. We aimed identify the research hotspots in this field through systematic analysis. Methods Relevant studies published January 1, 2004 December 31, 2023 were retrieved Web Science Core Collection database. The data analyzed visualized using CiteSpace, VOSviewer, SCImago Graphica. Results In total, 1,639 relevant publications retrieved. country with highest number was United States, most productive institution Harvard University, journal output Clinical Neurophysiology , total citations Neurology . author Steven Laureys common keyword “vegetative state.” Conclusion undergoing rapid development, characterized by proliferation advanced technologies an increased emphasis on international collaboration. document offers impartial perspective advancements study benefit researchers.

Language: Английский

Citations

0

Role of Ischemia/Reperfusion and Oxidative Stress in Shock State DOI Creative Commons

Yarielis Ivette Vázquez-Galán,

Sandra Guzmán-Silahua, Walter Ángel Trujillo-Rangel

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(11), P. 808 - 808

Published: May 30, 2025

Shock is a life-threatening condition characterized by inadequate tissue perfusion leading to systemic hypoxia and metabolic failure. Ischemia/reperfusion (I/R) injury exacerbates shock progression through oxidative stress immune dysregulation, contributing multi-organ dysfunction. This narrative review synthesizes current evidence on the interplay between I/R injury, stress, modulation in states. We analyze classification of shock, its progression, molecular pathways involved ischemic adaptation, inflammatory responses, injury. pathophysiology driven ischemia, triggering adaptive responses such as hypoxia-inducible factor (HIF) signaling reprogramming. However, prolonged leads mitochondrial dysfunction, increased reactive oxygen species (ROS) nitrogen (RNS) production, activation. The transition from response syndrome (SIRS) compensatory anti-inflammatory (CARS) contributes imbalance, further aggravating damage. Dysregulated checkpoint pathways, including CTLA-4 PD-1, fail suppress excessive inflammation, exacerbating exhaustion. intricate relationship ischemia/reperfusion dysregulation states highlights potential therapeutic targets. Strategies aimed at modulating redox homeostasis, controlling mitigating damage may improve patient outcomes. Future research should focus novel interventions that restore balance while preventing

Language: Английский

Citations

0