Effects of Live and Peptide-Based Antimicrobiota Vaccines on Ixodes ricinus Fitness, Microbiota, and Acquisition of Tick-Borne Pathogens DOI Creative Commons
Apolline Maître, Lourdes Mateos‐Hernández, Myriam Kratou

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 206 - 206

Published: Feb. 20, 2025

This study explored the effects of antimicrobiota vaccines on acquisition Borrelia and Rickettsia, microbiota composition Ixodes ricinus ticks. Using a murine model, we investigated immunological responses to live Staphylococcus epidermidis multi-antigenic peptide (MAP) vaccines. Immunized mice were infected with either afzelii or Rickettsia helvetica, subsequently infested pathogen-free I. nymphs. We monitored tick feeding behavior, survival rates, infection levels. Additionally, employed comprehensive analyses, including alpha beta diversity assessments microbial co-occurrence network construction. Our results indicate that both S. MAP elicited significant antibody in mice, notable bactericidal against epidermidis. The vaccination altered patterns fitness ticks, Live vaccine group showing higher weight faster time. Microbiota analysis revealed shifts between groups, distinct networks taxa abundances observed. Notably, exhibited more robust complex structure, while demonstrated resilience perturbations. However, appeared taxon-dependent, as inferred from our previous findings microbiota-driven pathogen refractoriness. Staphylococcus-based but had no effect B. infection, yielded inconclusive for R. helvetica. In contrast, studies suggest E. coli-based modulation can induce pathogen-refractory state, highlighting importance bacterial species selection shaping susceptibility. direct comparison under identical experimental conditions across multiple is required confirm this taxon-specific effect. These influences assembly, its transmission depend taxon targeted selected epitopes. research provides insights into need strategic enhance efficacy controlling tick-borne diseases.

Language: Английский

Effects of Live and Peptide-Based Antimicrobiota Vaccines on Ixodes ricinus Fitness, Microbiota, and Acquisition of Tick-Borne Pathogens DOI Creative Commons
Apolline Maître, Lourdes Mateos‐Hernández, Myriam Kratou

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(3), P. 206 - 206

Published: Feb. 20, 2025

This study explored the effects of antimicrobiota vaccines on acquisition Borrelia and Rickettsia, microbiota composition Ixodes ricinus ticks. Using a murine model, we investigated immunological responses to live Staphylococcus epidermidis multi-antigenic peptide (MAP) vaccines. Immunized mice were infected with either afzelii or Rickettsia helvetica, subsequently infested pathogen-free I. nymphs. We monitored tick feeding behavior, survival rates, infection levels. Additionally, employed comprehensive analyses, including alpha beta diversity assessments microbial co-occurrence network construction. Our results indicate that both S. MAP elicited significant antibody in mice, notable bactericidal against epidermidis. The vaccination altered patterns fitness ticks, Live vaccine group showing higher weight faster time. Microbiota analysis revealed shifts between groups, distinct networks taxa abundances observed. Notably, exhibited more robust complex structure, while demonstrated resilience perturbations. However, appeared taxon-dependent, as inferred from our previous findings microbiota-driven pathogen refractoriness. Staphylococcus-based but had no effect B. infection, yielded inconclusive for R. helvetica. In contrast, studies suggest E. coli-based modulation can induce pathogen-refractory state, highlighting importance bacterial species selection shaping susceptibility. direct comparison under identical experimental conditions across multiple is required confirm this taxon-specific effect. These influences assembly, its transmission depend taxon targeted selected epitopes. research provides insights into need strategic enhance efficacy controlling tick-borne diseases.

Language: Английский

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