Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 620 - 620
Published: April 25, 2025
Renal cell carcinoma (RCC) is the most lethal malignancy of urinary system, with limited treatment options due to drug resistance and adverse effects associated current therapies. This review aims systematically examine therapeutic potential flavonoids, which are natural polyphenolic compounds possessing anti-inflammatory, antioxidant, anticancer properties, in context RCC treatment. We summarize activities 26 classified into six subclasses, explore their mechanisms action, including inhibition tumor proliferation, migration, invasion, as well induction apoptosis, autophagy, ferroptosis. Particular attention paid modulation key signaling pathways such JAK/STAT3, PI3K/Akt/mTOR, miRNA-related axes, miR-21/YAP1 miR-324-3p/GPX4, providing a molecular basis for anti-RCC activity. also address several pharmacological challenges that limit clinical application poor bioavailability, metabolic instability, toxicity. Emerging solutions novel flavonoid derivatives, advanced delivery systems, rational combination therapy strategies discussed. Current evidence, phase II trial flavopiridol RCC, highlights but need further validation. In conclusion, flavonoids offer promising approach improving Future research should focus on optimizing efficacy ensuring safe translation, goal achieving personalized minimally invasive cancer
Language: Английский