Current Diabetes Reports, Journal Year: 2024, Volume and Issue: 25(1)
Published: Dec. 18, 2024
Abstract Purpose of Review This review explores the mechanisms through which gestational diabetes mellitus GDM impacts fetal kidney development, focusing on epigenetic alterations as mediators these effects. We examine influence nephrogenesis and maturation, exploring how hyperglycemia-induced intrauterine stress can reduce nephron endowment compromise renal function via dysregulation normal mechanisms. Recent Findings In addition to metabolic impacts, emerging evidence suggests that exerts its modifications, including DNA methylation, histone non-coding RNA expression, disrupt gene expression patterns critical for development. Recently, specific modifications observed in offspring exposed were implicated aberrant activation or repression genes essential Key pathways influenced by changes, such oxidative response, inflammatory regulation, pathways, are discussed illustrate broad molecular impact Finally, we consider potential intervention strategies could mitigate adverse effects These include optimizing maternal glycemic control, dietary supplementation, pharmacological agents targeting pathways. Summary Through a comprehensive synthesis current research, this underscores importance early preventive burden disease individuals highlights key altered during
Language: Английский