Revitalizando las terapias en enfermedades autoinmunes: Nanopartículas como alternativa de tratamiento

Actualidades Biológicas, Journal Year: 2025, Volume and Issue: 74(122)

Published: Jan. 1, 2025

Las enfermedades autoinmunes son trastornos complejos caracterizados por una respuesta inmune anormal. En estas enfermedades, el sistema identifica erróneamente diferentes componentes del propio organismo como extraños, lo que provoca inflamación crónica y daño en múltiples sistemas de órganos tejidos. Los tratamientos actuales suelen implicar uso fármacos inmunosupresores suprimen ampliamente la inmune. Aunque estos medicamentos pueden ayudar a aminorar los síntomas, también conlleva importantes efectos secundarios debido su naturaleza inespecífica. La nanotecnología, través nanomedicina, juega un papel crucial tratamiento mejorando eficacia terapéutica minimizando toxicidad. Esta tecnología permite mejorar biodisponibilidad medicamentos, distribución más precisa cuerpo control exacto sobre liberación fármacos. nanopartículas (NP) fundamentales este proceso, capaces superar barreras biológicas dirigir directamente sitios afectados, aumenta reduce secundarios. Este enfoque es especialmente prometedor cáncer, donde las NP dirigirse células específicas, macrófagos, monocitos, dendríticas linfocitos B, para entregar manera efectiva, con menos toxicidad adversos. investigación nanotecnología continúa avanzando, ofreciendo esperanza efectivos personalizados.

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Freeze-dried chrome shaving collagen-amyloid beta peptide-carbon nano (CSC-AβP-CN) scaffolds for enhanced antibacterial, biocompatible, and drug delivery applications in skin tissue engineering

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130673 - 130673

Published: March 1, 2025

Language: Английский

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State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103527 - 103527

Published: April 25, 2025

Language: Английский

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Advances in photothermal therapy for cancer and bacterial cells ablation using various nanomaterials

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103541 - 103541

Published: May 1, 2025

Language: Английский

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Modulated Optoelectronic Properties of MOF/CNF Bionanocomposite Films for Bacterial Growth Control under Visible Light

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 10, 2025

The present work reports an experimental and theoretical investigation of tuning the optoelectronic properties MIL-125-NH2 nanoparticles by grafting aromatic molecules. postsynthetic modification MOF with 3,4-dihydroxybenzaldehyde (DBA) resulted in a 23% reduction bandgap energy, from 2.71 to 2.08 eV, while increasing absorbance throughout visible region spectrum, which could be attributed stabilization due enol-imine/keto-enamine tautomerism, as supported DFT calculations. Pristine grafted MOFs were assembled into cellulose nanofibers (CNF) for preparation functional CNF-based bionanocomposites. mechanical films improved, Young's modulus 1.3 GPa CNF 7.5 film 20% loading. potential developed materials photocatalytic antimicrobial therapy was evaluated against Staphylococcus aureus (S. aureus). In vitro tests showed that both bionanocomposite pristine DBA-modified remarkably reduced bacterial growth action under light. inhibition values around 58% 72%, respectively, minimal observed dark conditions. These initial results support use wound dressings.

Language: Английский

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Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2813 - 2846

Published: March 1, 2025

Abstract: Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, due to their unique structures, high bioactivities, excellent designability characteristics, an increasing number of studies been devoted modifying these species generate novel composites with desirable optical, electrical, magnetic properties. However, few systematic detailed reviews performed relating the modification approaches available MNPs resulting composites. In this review, a comprehensive summary is regarding optimized formulations application dressings, techniques used prepare composite dressings are discussed. addition, safety profiles nanocomposite limitations reported systems evaluated. More importantly, solution strategies proposed address limitations. Overall, review provides new ideas design facilitate field skin repair, also looks into future direction biomedical field. Keywords: metal-based nanoparticles, nanocomposite, dressing, multi-functional,

Language: Английский

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Hyaluronic acid and ZIF-8 nanocomposites for wound care

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 144475 - 144475

Published: May 1, 2025

Language: Английский

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