Changes in tumor and cardiac metabolism upon immune checkpoint DOI Creative Commons
Anna‐Sophia Leven, Natalie Wagner, Stephan Nienaber

et al.

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Cardiovascular disease and cancer are the leading causes of death in Western world. The associated risk factors increased by smoking, hypertension, diabetes, sedentary lifestyle, aging, unbalanced diet, alcohol consumption. Therefore, study cellular metabolism has become increasing importance, with current research focusing on alterations adjustments patients. This may also affect efficacy tolerability anti-cancer therapies such as immune-checkpoint inhibition (ICI). review will focus metabolic adaptations their consequences for various cell types, including cells, cardiac myocytes, immune cells. Focusing ICI, we illustrate how interact metabolism. In addition to desired tumor response, highlight that ICI can lead a variety side effects impact or vice versa. With regard cardiovascular system, ICI-induced cardiotoxicity is increasingly recognized one most life-threatening adverse events mortality up 50%. As such, significant efforts being made assess specific interactions changes ICIs improve both management effects.

Language: Английский

Changes in tumor and cardiac metabolism upon immune checkpoint DOI Creative Commons
Anna‐Sophia Leven, Natalie Wagner, Stephan Nienaber

et al.

Basic Research in Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Cardiovascular disease and cancer are the leading causes of death in Western world. The associated risk factors increased by smoking, hypertension, diabetes, sedentary lifestyle, aging, unbalanced diet, alcohol consumption. Therefore, study cellular metabolism has become increasing importance, with current research focusing on alterations adjustments patients. This may also affect efficacy tolerability anti-cancer therapies such as immune-checkpoint inhibition (ICI). review will focus metabolic adaptations their consequences for various cell types, including cells, cardiac myocytes, immune cells. Focusing ICI, we illustrate how interact metabolism. In addition to desired tumor response, highlight that ICI can lead a variety side effects impact or vice versa. With regard cardiovascular system, ICI-induced cardiotoxicity is increasingly recognized one most life-threatening adverse events mortality up 50%. As such, significant efforts being made assess specific interactions changes ICIs improve both management effects.

Language: Английский

Citations

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