Cholangiocarcinoma: The era of liquid biopsy DOI
Evgenia Kotsifa, Francesca Saffioti, Vasileios Mavroeidis

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(11)

Published: March 12, 2025

Cholangiocarcinoma (CCA) is a highly aggressive and heterogeneous malignancy arising from the epithelial cells of biliary tract. The limitations current methods in diagnosis CCA highlight urgent need for new, accurate tools early cancer detection, better prognostication patient monitoring. Liquid biopsy (LB) modern non-invasive technique comprising diverse group methodologies aiming to detect tumour biomarkers body fluids. These include circulating cells, cell-free DNA, RNA extracellular vesicles. aim this review explore potential future applications LB management, with focus on diagnosis, We examine both its significant inevitable associated technology. conclude that holds considerable promise, but further research necessary fully integrate it into precision oncology CCA.

Language: Английский

Cholangiocarcinoma: The era of liquid biopsy DOI
Evgenia Kotsifa, Francesca Saffioti, Vasileios Mavroeidis

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(11)

Published: March 12, 2025

Cholangiocarcinoma (CCA) is a highly aggressive and heterogeneous malignancy arising from the epithelial cells of biliary tract. The limitations current methods in diagnosis CCA highlight urgent need for new, accurate tools early cancer detection, better prognostication patient monitoring. Liquid biopsy (LB) modern non-invasive technique comprising diverse group methodologies aiming to detect tumour biomarkers body fluids. These include circulating cells, cell-free DNA, RNA extracellular vesicles. aim this review explore potential future applications LB management, with focus on diagnosis, We examine both its significant inevitable associated technology. conclude that holds considerable promise, but further research necessary fully integrate it into precision oncology CCA.

Language: Английский

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