Which has a more protective effect against neuronal changes in the cingulate cortex of newborn rats of diabetic mothers: omega 3 or glutathione?

Ultrastructural Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: April 11, 2025

Different researches suggests that unchecked maternal hyperglycemia during pregnancy may negatively impact the offspring's neurodevelopment. Omega 3 polyunsaturated fatty acids are vital antioxidant micronutrients for neurological health. Glutathione (GSH) is an essential non-enzymatic in mammalian cells. The study aimed to assess possible ameliorative effect of omega3 versus GSH against neuronal changes cingulate cortex new born rats diabetic mothers. Fifty female were divided randomly into 5 equal groups: Group I given saline, group II where induction diabetes by single intraperitoneal injection 150 mg/kg alloxan monohydrate, III oral omega at a dose 300 mg/kg, IV injections (200 mg/kg) and V both with same routes regimens as throughout whole pregnancy. newborn each was collected anaesthetized then brain specimens extracted processed light, immunohistochemical electron microscopic studies. showed marked degenerative all layers light microscopy. most degree improvement comparison IV. There strong caspase3 immunoreaction while weak reaction appeared III, V. We concluded combined administration mitigate adverse effects on newborn's cortex.

Language: Английский

Chlorella vulgaris Supplementation Attenuates Lead Accumulation, Oxidative Stress, and Memory Impairment in Rats

Toxics, Journal Year: 2025, Volume and Issue: 13(4), P. 313 - 313

Published: April 18, 2025

Lead is a harmful heavy metal known to alter the environment and affect human health. Several industries have contributed increase in lead contamination, making it major global concern. Thus, remediation strategies are necessary prevent bioaccumulation deleterious health effects. The aim of this study was determine capacity green microalga Chlorella vulgaris (C. or CV) remove an animal model accumulation principal organs (brain, liver, kidney) blood. Forty male Wistar rats were randomly assigned four groups (n = 10): control group (CT); C. supplementation group, 5% diet (CV); acetate administration 500 ppm (Pb); plus (CV–Pb). After 4 weeks exposure, we measured accumulation, memory function, oxidative stress, antioxidant activity (SOD GSH). exposure altered increased stress brain kidney, SOD brain. Supplementation with restored function levels; reduced kidney; decreased blood exposed lead. Based on our results, chelating agent models.

Language: Английский