The Double Life of microRNAs in Bone Sarcomas: Oncogenic Drivers and Tumor Suppressors DOI Open Access
Stefano Zoroddu,

Fabio Sias,

Luigi Bagella

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4814 - 4814

Published: May 17, 2025

Bone sarcomas, including Osteosarcoma, Ewing’s sarcoma, and Chondrosarcoma, are rare yet aggressive tumors with high metastatic potential poor survival outcomes. Despite advances in surgical chemotherapeutic techniques, these malignancies remain difficult to treat. They often exhibit resistance conventional therapies associated a limited prognosis for patients. MicroRNAs (miRNAs) have emerged as pivotal regulators of cancer biology, orchestrating crucial processes such cell proliferation, apoptosis, metastasis. Their double life oncogenes or tumor suppressors underscores their significance the pathogenesis bone sarcomas. This review examines multifaceted roles miRNAs malignancies. By elucidating complex networks affected by miRNA dysregulation, we seek identify novel avenues miRNA-based interventions. It is intention this work stimulate future research clinical strategies that exploit transform management outcomes

Language: Английский

The Double Life of microRNAs in Bone Sarcomas: Oncogenic Drivers and Tumor Suppressors DOI Open Access
Stefano Zoroddu,

Fabio Sias,

Luigi Bagella

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4814 - 4814

Published: May 17, 2025

Bone sarcomas, including Osteosarcoma, Ewing’s sarcoma, and Chondrosarcoma, are rare yet aggressive tumors with high metastatic potential poor survival outcomes. Despite advances in surgical chemotherapeutic techniques, these malignancies remain difficult to treat. They often exhibit resistance conventional therapies associated a limited prognosis for patients. MicroRNAs (miRNAs) have emerged as pivotal regulators of cancer biology, orchestrating crucial processes such cell proliferation, apoptosis, metastasis. Their double life oncogenes or tumor suppressors underscores their significance the pathogenesis bone sarcomas. This review examines multifaceted roles miRNAs malignancies. By elucidating complex networks affected by miRNA dysregulation, we seek identify novel avenues miRNA-based interventions. It is intention this work stimulate future research clinical strategies that exploit transform management outcomes

Language: Английский

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