Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway DOI Creative Commons
Xiaoyu Niu, Yuanyuan Zheng,

Wang Wang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

ABSTRACT Background Esketamine (ESK), a noncompetitive antagonist of N‐methyl‐D‐aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous system. However, specific mechanisms and therapeutic potential ESK for intracerebral hemorrhage (ICH) remain unclear. This study aimed to investigate whether promotes nerve repair improves neurological outcomes an experimental model ICH. Methods ICH was induced mice via collagenase injection into striatum. Body weight, impairment, behavioral changes were assessed. administration significantly improved several indicators Comprehensive RNA transcriptome sequencing network pharmacology analyses identified neurotrophin‐3 (NTF3) PI3K/AKT pathway as targets treatment. Western blotting immunofluorescence detected protein expression levels cellular localization NTF3. Results After 28 days adeno‐associated virus infection mouse striatum, treatment enhanced neuroprotection, indicating crucial role NTF3 ESK‐mediated neuroprotection mice. Inhibition using PI3K‐specific inhibitor LY294002 attenuated effects ESK, suggesting that this is involved neurorepair Conclusions functional demonstrated neuroprotective animal models NTF3/PI3K/AKT activation by indicates its

Language: Английский

Immune‐mediated disruption of the blood–brain barrier after intracerebral hemorrhage: Insights and potential therapeutic targets DOI Creative Commons

Peijun Jia,

Qinfeng Peng,

Xiaochong Fan

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Intracerebral hemorrhage (ICH) is a condition that arises due to the rupture of cerebral blood vessels, leading flow into brain tissue. One pathological alterations occurs during an acute ICH impairment blood-brain barrier (BBB), which leads severe perihematomal edema and immune response.

Language: Английский

Citations

10
Unraveling the Protein Post-translational Modification Landscape: Neuroinflammation and Neuronal Death after Stroke DOI

Jin Tao,

Jiaxin Li, Xiaochong Fan

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: unknown, P. 102489 - 102489

Published: Sept. 1, 2024

Language: Английский

Citations

9
Distribution of Intranasally Administered rIL‐10 Along the Olfactory Nerve and Perivascular Space After Intracerebral Hemorrhage DOI Creative Commons
Shaoshuai Wang, Junmin Wang, X.B Zhang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 1, 2025

The utilization of anti-inflammatory therapy for treating brain diseases holds promise; however, research on intranasal administration drug compounds remains limited. Quantitative data, particularly pharmacokinetics, are scant, and direct evidence the distribution intranasally administered recombinant interleukin 10 (rIL-10) within is lacking. Employing fluorescent labeling, in vivo imaging, confocal microscopy, we meticulously monitored delivery pathways rIL-10 brain. Our findings demonstrate that can permeate blood-brain barrier reach perihematomal area striatum mice with intracerebral hemorrhage. Intranasally primarily targets cerebral cortex, striatum, thalamus, traversing olfactory nerve pathway perivascular space to access these regions. This mode effectively mitigated secondary injury after study contributes research, offering compelling support cytokines or alternative candidates diseases.

Language: Английский

Citations

0
Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage DOI Creative Commons
Shiling Chen, Liyang Huang, Jingyi Wang

et al.

Brain Hemorrhages, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Toll-Like Receptors Mediate Opposing Dendritic Cell Effects on Treg/Th17 Balance in Mice With Intracerebral Hemorrhage DOI
Li Zhu, Junkui Shang, Yinuo Li

et al.

Stroke, Journal Year: 2024, Volume and Issue: 55(8), P. 2126 - 2138

Published: June 26, 2024

Dendritic cells (DCs) regulate the immune response associated with T lymphocytes, but their role in stroke remains unclear. In this study, we investigated causal relationship between DCs and T-cell intracerebral hemorrhage (ICH) by focusing on TLRs (toll-like receptors) that may modulate function of DCs.

Language: Английский

Citations

2
Central post-stroke pain: advances in clinical and preclinical research DOI Creative Commons

Xiqian Yuan,

Siyuan Hu, Xiaochong Fan

et al.

Stroke and Vascular Neurology, Journal Year: 2024, Volume and Issue: unknown, P. svn - 003418

Published: Sept. 28, 2024

Central poststroke pain (CPSP) is a medical complication that arises and significantly impacts the quality of life social functioning affected individuals. Despite ongoing research, exact pathomechanisms CPSP remain unclear, practical treatments are still unavailable. Our review aims to systematically analyse current clinical preclinical studies on CPSP, which critical for identifying gaps in knowledge guiding development effective therapies. The will clarify characteristics, evaluation scales contemporary therapeutic approaches based investigations. It particularly emphasise model initiated by stroke, shedding light its underlying mechanisms evaluating validated studies. Furthermore, not only highlight methodological limitations animal trials but also offer specific recommendations researchers improve future investigations guide This expected provide valuable insights into regarding can serve as research practice. contribute scientific understanding help develop interventions.

Language: Английский

Citations

1
Serum cholesterol and interleukin-10 are associated with post-intracerebral hemorrhage depression in patients with acute primary supratentorial intracerebral hemorrhage DOI Creative Commons

Liping Wei,

Zhihua Liu, Hui Cai

et al.

Brain Hemorrhages, Journal Year: 2024, Volume and Issue: 5(5), P. 237 - 242

Published: May 29, 2024

This study explores the correlation between serum cholesterol, interleukin-10 (IL-10), macrophage migration inhibitory factor (MIF), and post-intracerebral hemorrhage (post-ICH) depression in patients with acute ICH 35 primary supratentorial were recruited. Serum including total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDLC), low-density (LDLC), IL-10, MIF measured first morning after admission. Additionally, a 24-item Hamilton Depression Scale (HAMD-24) was used to detect depressive symptoms one week HAMD scores ≥ 8 indicated diagnosis of post-ICH depression. The levels TC significantly lower compared those without [169.26(139.23–215.67) mg/dL vs. 200.46(182.81–224.74) mg/dL, P = 0.010]. Similarly, LDLC [102.18(78.39–137.28) 135.14(120.22–170.63) 0.001] IL-10 [17.56(16.03–22.52) pg/mL 31.17(23.42–37.53) pg/mL, also Furthermore, (r -0.433, 0.009), TG -0.345, 0.043), -0.549, 0.001), -0.603, < 0.001) showed negative correlations scores. Logistic regression analysis that higher (OR 0.847, 95 % CI 0.717–0.999, 0.049) indicative protection against phase. Lower TC, LDLC, associated during decreased may serve as promising predictor for

Language: Английский

Citations

0
Esketamine Provides Neuroprotection After Intracerebral Hemorrhage in Mice via the NTF3/PI3K/AKT Pathway DOI Creative Commons
Xiaoyu Niu, Yuanyuan Zheng,

Wang Wang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(12)

Published: Dec. 1, 2024

ABSTRACT Background Esketamine (ESK), a noncompetitive antagonist of N‐methyl‐D‐aspartate (NMDA) receptors, modulates neurotransmitter signaling in the central nervous system. However, specific mechanisms and therapeutic potential ESK for intracerebral hemorrhage (ICH) remain unclear. This study aimed to investigate whether promotes nerve repair improves neurological outcomes an experimental model ICH. Methods ICH was induced mice via collagenase injection into striatum. Body weight, impairment, behavioral changes were assessed. administration significantly improved several indicators Comprehensive RNA transcriptome sequencing network pharmacology analyses identified neurotrophin‐3 (NTF3) PI3K/AKT pathway as targets treatment. Western blotting immunofluorescence detected protein expression levels cellular localization NTF3. Results After 28 days adeno‐associated virus infection mouse striatum, treatment enhanced neuroprotection, indicating crucial role NTF3 ESK‐mediated neuroprotection mice. Inhibition using PI3K‐specific inhibitor LY294002 attenuated effects ESK, suggesting that this is involved neurorepair Conclusions functional demonstrated neuroprotective animal models NTF3/PI3K/AKT activation by indicates its

Language: Английский

Citations

0