Endothelial Dysfunction in Obesity and Therapeutic Targets

Advances in experimental medicine and biology, Journal Year: 2024, Volume and Issue: unknown, P. 489 - 538

Published: Jan. 1, 2024

Language: Английский

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Remnant cholesterol and low-grade inflammation jointly in atherosclerotic cardiovascular disease: implications for clinical trials

Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2023, Volume and Issue: 27(2), P. 125 - 135

Published: Nov. 21, 2023

Purpose of review Atherosclerotic cardiovascular disease (ASCVD) is the leading cause death despite development effective treatments. Recently, elevated remnant cholesterol and low-grade inflammation have emerged as factors explaining part residual ASCVD risk. Interestingly, coexistence both high can further increase risk ASCVD. The aim this to describe role inflammation, separately combined, in Recent findings Results from recently published studies, including observational genetic Mendelian randomization support a causal relationship between on primary secondary prevention settings. In addition, current evidence studies suggests that increases Summary suggest combined with may confer particular for Attention dual threat necessary, research field warranted. effect cholesterol-lowering drugs anti-inflammatory alone remains be elucidated. Video abstract http://links.lww.com/COCN/A20

Language: Английский

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Cumulative residual cholesterol predicts the risk of cardiovascular disease in the general population aged 45 years and older

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Jan. 19, 2024

Abstract Background Numerous studies have affirmed a robust correlation between residual cholesterol (RC) and the occurrence of cardiovascular disease (CVD). However, current body literature fails to adequately address link alterations in RC CVD. Existing focused mainly on individual values. Hence, primary objective this study is elucidate association cumulative (Cum-RC) morbidity Methods The changes were categorized into high-level fast-growth group (Class 1) low-level slow-growth 2) by K-means cluster analysis. To investigate relationship combined exposure multiple lipids CVD risk, weighted quantile sum (WQS) regression analysis was employed. This involved calculation weights for total (TC), low-density lipoprotein (LDL), high-density (HDL), which used effectively RC. Results Among cohort 5,372 research participants, considerable proportion 45.94% consisted males, with median age 58. In three years follow-up, 669 participants (12.45%) had Logistic revealed that Class 2 individuals significantly reduced risk developing compared 1. probability having increased 13% every 1-unit increase Cum-RC according continuous variables. restricted cubic spline (RCS) showed linearly related ( P nonlinearity = 0.679). WQS results nonsignificant trend toward an index incidence but overall positive trend, greatest contribution from TC (weight 0.652), followed LDL 0.348). Conclusion positively strongly suggesting addition focusing traditional lipid markers, early intervention patients may further reduce

Language: Английский

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Low remnant cholesterol and the subsequent risk of new-onset atrial fibrillation: A prospective cohort study

Heart Rhythm, Journal Year: 2024, Volume and Issue: 21(8), P. 1258 - 1266

Published: May 28, 2024

Language: Английский

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Causal association between remnant cholesterol level and risk of cardiovascular diseases: a bidirectional two sample mendelian randomization study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 7, 2024

Serum lipids have been associated with an increased risk of various cardiovascular diseases (CVDs) in several observational studies, but the causal inference between remnant cholesterol (RC) levels and CVDs has not established. The purpose this study was to investigate whether there is a relationship RC developing by bidirectional two-sample Mendelian randomization (TSMR) analysis. One TSMR analysis performed using publicly released large-scale genome-wide association (GWAS) data. Inverse variance weighted (IVW) method chosen as main method, MR-Egger, median, simple mode, mode were used supplementary methods. We conducted series sensitivity analyses assess robustness results, including Cochran's Q test, MR-Egger intercept leave-one-out analysis, funnel plot. IVW revealed that genetically predicted serum level significantly ischemic heart disease (OR = 1.409, 95%CI 1.284-1.546, P value 4.753E-13), unstable angina pectoris 1.621, 1.398-1.880, 1.672E-10), myocardial infarction 1.526, 1.337-1.741, 3.771E-10), cardiac arrest 1.595, 1.322-1.924, 1.076E-06), failure 1.086, 1.009-1.169, 0.028), hypertension 1.089, 1.043-1.136, 9.458E-05), major coronary (CHD) events 1.515, 1.376-1.669, 3.217E-17), atherosclerosis 1.388, 1.231-1.564, 7.739E-08), arrhythmias 1.067, 1.008-1.130, 0.025), atrial fibrillation flutter 1.122, 1.039-1.211, 0.003). Additionally, associations these remained significant after correcting for false discovery rate (all < 0.05). However, did find any cardiomyopathy pericarditis (both > Heterogeneity existed IVs disease, pectoris, infarction, failure, hypertension, CHD events, cardiomyopathy, atherosclerosis, test Moreover, no horizontal pleiotropy showed effects (except arrhythmias) are driven single SNP. plots obvious potential bias our study. In replication positively 43.12% higher artery disease. This present supported link heightened CVDs, indicating RC-lowering treatment might be effective preventing CVDs.

Language: Английский

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Co-morbid intersections of cancer and cardiovascular disease and targets for natural drug action: Reprogramming of lipid metabolism

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116875 - 116875

Published: June 7, 2024

Cancer and cardiovascular diseases are major contributors to global morbidity mortality, their seemingly separate pathologies intricately intertwined. In the context of cancer, disease encompasses not only side effects arising from anti-tumor treatments but also metabolic shifts induced by oncological conditions. A growing body research indicates that lipid reprogramming serves as a distinctive hallmark tumors. Furthermore, anomalies in metabolism play significant role development disease. This study delves into cardiac implications within cancer context, closely examining abnormalities present tumors, tissue, immune cells microenvironment. Additionally, we examined risk factors such obesity therapy. Despite progress, gap remains availability drugs targeting modulation for treating tumors mitigating risk, with limited advancement seen prior studies. Here, review previous on natural exhibit both shared distinct therapeutic health modulating metabolism. Our aim is provide insights potential drug development.

Language: Английский

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It is Time to Address the Contribution of Cholesterol in all APOB-Containing Lipoproteins to Atherosclerotic Cardiovascular Disease

European Heart Journal Open, Journal Year: 2024, Volume and Issue: 4(4)

Published: July 1, 2024

On average, LDL particles are the most populous lipoprotein in serum under fasting conditions. For many reasons, it has been primary target of lipid-lowering guidelines around world. In past 30 years, we have witnessed remarkable changes each iteration dyslipidaemia guidelines, with LDL-cholesterol (LDL-C) targets becoming lower and among patients at high very risk for atherosclerotic cardiovascular disease (ASCVD). The world over, goal attainment rates low, hence, ASCVD prevalence remains unacceptably high. Inadequate LDL-C lowering is a major issue contemporary (CV) medicine. Another that vexes even astute clinician 'residual risk', meaning excess after appropriately reduced. recent an important new component residual emerged: triglyceride-enriched lipoproteins or remnant lipoproteins. These precursors to can assume outsized importance derangements triglyceride metabolism (e.g. genetic variants, insulin resistance, diabetes mellitus) may be more atherogenic than species. Consequently, reduce total acute CV events, time come include entire spectrum apoB-containing approaches both evaluation treatment.

Language: Английский

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Triglycerides and Cardiovascular Risk

Journal of the American College of Cardiology, Journal Year: 2024, Volume and Issue: 84(11), P. 1007 - 1009

Published: Sept. 1, 2024

Language: Английский

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Comparative analysis of neutrophil-to-lymphocyte ratio and remnant cholesterol in predicting cardiovascular events and mortality in general adult population

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: Dec. 15, 2023

This study aimed to investigate the predictive value of neutrophil-to-lymphocyte ratio (NLR) and Remnant Cholesterol (Remnant-C) in relation cardiovascular events all-cause mortality general population. A population-based study. We conducted a retrospective cohort analyzing data from National Health Nutrition Examination Survey (NHANES) spanning years 2011-2018, with follow-up for status until December 31, 2019. Kaplan‒Meier Cox proportional hazards regression analyses were used evaluate associations between NLR, Remnant-C, as well mortality. Overall, 9409 individuals both complete blood count lipids included analysis. Baseline NLR Remnant-C calculated. During (median, 59.3 months), 177 561 occurred. In fully adjusted model, people > 2.26 significantly associated higher risk (HR 2.14, 95% CI 1.30-3.52, P < 0.001) 1.66, 1.30-2.12, 0.001). exhibited positive correlation (r = 0.04, Elevated levels shown stronger association 1.21, 1.14-2.28, compared 1.02, 1.00-1.04, 0.020). Our findings suggest that are potential markers observed high demonstrate prediction Remnant-C.

Language: Английский

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Current trends in solving the problem of residual cardiovascular risk

Meditsinskiy sovet = Medical Council, Journal Year: 2024, Volume and Issue: 6, P. 155 - 163

Published: May 19, 2024

Cardiovascular mortality is an urgent health problem not only in the Russian Federation, but also throughout world. Patients of high cardiovascular risk, which suffering from ischemic heart disease and attending dyslipidemia, remain with residual risk complications such as unstable angina, myocardial infarction, stroke even case achieved target level atherogenic lipoproteins, no matter effective multicomponent hypolipidemic therapy. This article reviews relevant scientific literature, meta-analyses studies, randomized clinical trials lipid-lowering drugs, examines main reasons for persistence evaluates role each diagnostic marker its progression, among are lipoprotein (a), triglycerides other persistent aseptic inflammation vascular wall, markers highly sensitive C-reactive protein, interleukin-6, interleukin-1β. Possible therapeutic strategies reducing depending on etiological factor discussed including effectiveness omega-3 polyunsaturated fatty acids, fibrates, options RNA interference small interfering antisense oligonucleotides usage, apheresis, well anti-inflammatory therapy using colchicine, low doses methotrexate monoclonal antibodies that inhibit production proinflammatory interleukins. Assessing a patient’s practice allows us to determine insufficiency or ineffectiveness secondary prevention measures choose different, more modern comprehensive tactic reducing.

Language: Английский

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