Remnant Cholesterol as a Predictor of Cardiovascular Outcomes in Acute Coronary Syndrome Patients with Low-Density Lipoprotein Cholesterol Levels Below 1.8 mmol/L: Insights from the MPCS-ACS Study

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Aims: This study aimed to investigate the influence of remnant cholesterol (RC) on risk cardiovascular events in patients with acute coronary syndrome (ACS) who have tightly controlled low-density lipoprotein (LDL-C) levels. Methods: Analyzing data from MPCS-ACS study, this investigation targeted individuals aged 18 79 diagnosed ACS, were admitted three Chinese medical centers between June 2016 and May 2021, maintained LDL-C levels below 1.8 mmol/L. Results: Out 17,500 screened patients, 4,329 analyzed. RC calculated, then categorized into quartiles. The primary focus was all-cause mortality. Secondary objectives involved assessing incidence major adverse cerebrovascular (MACCE) as well (MACE). Through analysis outcome across different groups, coupled multivariable adjustments use restricted cubic splines, findings revealed that is a significant, independent factor for outcomes ACS when are strictly mmol/L, association remains significant even further 1.4 Restricted splines illustrated U-shaped, non-linear relationship endpoint (all-cause mortality, MACE, MACCE), lowest observed at ranging 0.29 0.45 Conclusions: identifies an complications highlights its U-shaped correlation outcomes.

Language: Английский

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Triglyceride-glucose index mediates the association between residual cholesterol and stroke among middle-aged and older adults in China: a prospective, nationwide, population-based study

Frontiers in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 5, 2024

Background Both triglyceride-glucose (TyG) index and residual cholesterol (RC) are predictors of stroke; however, to what extent the RC is associated with stroke through TyG unclear. This study examined whether mediates association incident interaction or joint relations in middle-aged older Chinese adults. Methods an ongoing prospective cohort initiated 2011 that included 10,569 adults without at baseline. The exposure was RC, mediator index, outcome which followed up from June, 2011, 2018. Mediation analysis used explore mediated between risk. Results Of participants, 4,978 (47.1%) were men; mean (SD) age 59.01 (9.43) years. During a median follow-up 7.1 years, 734 (7.0%) participants experienced stroke. In adjusted Cox models, A one SD increase elevated risk (HR, 1.09; 95% CI, 1.02–1.16), as well 1.14; 1.06–1.23). No significant multiplicative additive interactions found on (HR for multiplicative: 1.07, 0.67–1.70; Synergy index: 1.05, 0.16–6.88). (b, −0.16; −0.30 −0.03). Subgroup analyses sensitivity showed consistent results. Conclusions evidence completely among These findings highlight importance considering assessment.

Language: Английский

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Association of cumulative exposure to triglyceride and remnant cholesterol with the risk of cardiovascular disease in hypertensive patients with target LDL-C

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract Background The associations of cumulative exposure to triglycerides (cumTG) and remnant cholesterol (cumRC) with cardiovascular disease (CVD) risk in patients optimal low-density lipoprotein (LDL-C) levels remain uncertain. We aimed explore the relationship between cumTG cumRC CVD hypertensive target LDL-C. Methods A total 12,086 participants LDL-C level who completed three health examinations from 2006 2010 were enrolled followed until December 31, 2022. burden was derived by multiplying average interval two consecutive assessments. primary outcome included a composite events (myocardial infarction, ischemic stroke, hemorrhage stroke). Participants divided into 4 groups based on median values assess their joint associations. Cox proportional hazard models used calculate ratio (HR) 95% confidence intervals (CI) risk. Results During follow-up 11.95 years, 1,392 developed CVD. After multivariable adjustment, compared low cumTG/low group, both high cumTG/high group (HR 1.43, CI 1.24‒1.64) 1.26, 1.07‒1.49), but not 1.01, 0.84‒1.20), associated higher Conclusions In met LDL-C, RC factor for exhibited stronger association burden.

Language: Английский

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