Biomarkers of Importance in Monitoring Heart Condition After Acute Myocardial Infarction DOI Open Access
Aneta Aleksova, Alessandra Lucia Fluca, Antonio Paolo Beltrami

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 129 - 129

Published: Dec. 29, 2024

Despite notable advancements in cardiovascular medicine, morbidity and mortality rates associated with myocardial infarction (MI) remain high. The unfavourable prognosis absence of robust post-MI protocols necessitate further intervention. In this comprehensive review, we will focus on well-established novel biomarkers that can provide insight into the processes occur after an ischemic event. More precisely, during follow-up, it is particular importance to monitor indicate increase stretch stress, damage death cardiomyocytes, remodelling extracellular matrix, oxidative inflammation. This enables identification abnormalities a timely manner, as well capacity respond promptly any changes. Therefore, would like highlight well-known markers, such natriuretic peptides, high-sensitivity troponins, soluble suppression tumorigenicity 2, galactin-3, C-reactive protein, interleukins settings, adrenomedullin, growth differentiation factor-15, insulin-like factor binding protein 7, amyloid beta, vitamin D, trimethylamine N-oxide, advanced glycation end-products recently emerged filed. implementation protocols, which encompass monitoring aforementioned deemed pertinent, conjunction adherence established cardiac rehabilitation programmes, along already therapeutic strategies control risk factors, has potential markedly enhance patient outcomes reduce elevated level mortality.

Language: Английский

Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis DOI Creative Commons

Xiaohui Leng,

Xiunan Wei, Jun Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Trimethylamine N-oxide (TMAO), a metabolite dependent on intestinal microbiota, is closely related to the emergence, progression, and prognosis of cardiovascular disease (CVD), has received increasing attention in recent years. The current research hotspots future development trends TMAO CVD field are found through bibliometrics analysis, which provides reference for further study. tools VOSviewer CiteSpace were used analyze publications from Web Science Core Collection (WOSCC) database. articles published 2004 2024 about relationship between retrieved. Bibliometric analysis includes annual publications, countries/regions, institutions, authors co-cited authors, journals cited-journals, references keywords. After searching screening, 1,466 included subsequent bibliometric analysis. Since 2014, number exposing increased rapidly, as frequency citations. China, USA Italy countries that publish most relevant research. Cleveland Clinic leading institution this field. Stanley L Hazen, Zeneng Wang W H Wilson Tang prolific field, latter two have closest academic cooperation. American Journal Clinical Nutrition Heart Association influential "Gut Microbial Metabolite Enhances Platelet Hyperreactivity Thrombosis Risk" frequently cited article. Keyword shows gut metabolism, phosphatidylcholine atherosclerosis (AS) This study summarizes situation past 20 years, focusing effect pathogenesis AS, predictive value risk, dietary drug intervention TMAO. Probiotics natural products may be focus preventing treating by intervening future.

Language: Английский

Citations

0
Targeting gut-immune-heart modulate cardiac remodeling after acute myocardial infarction DOI Creative Commons

Jinmei Yu,

Lin Zhou, Guo Li

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123606 - 123606

Published: April 1, 2025

The gut microbiota interacts with the host to regulate disease and health status. An increasing number of studies have recognized bidirectional regulation between immune cells, which plays a significant role in etiology prognosis diseases. Gut is also crucial regulatory factor cardiovascular After acute myocardial infarction, endothelial damage rapidly triggers an inflammatory response, activating system disrupting ecology, thereby affecting cardiac remodeling after infarction potentially leading heart failure. We elucidated mechanisms complex intercellular networks during infarction. Furthermore, this research examines roles microbiota, metabolites relation failure Finally, we discuss potential targeting cells as effective approach prevent treat future, through methods such dietary regulation, probiotic supplementation, transplantation.

Language: Английский

Citations

0
Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas DOI Creative Commons
Alma Martelli,

Francesca Abate,

Michele Roggia

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 517 - 517

Published: April 25, 2025

Trimethylamine N-oxide (TMAO) is an endogenous osmolyte produced by enzymatic reactions starting in the human gut, where microbiota release trimethylamine (TMA) from foods, and ending liver, TMA oxidized to TMAO flavin-containing monooxygenase 3 (FMO3). While physiological concentrations of help proteins preserve their folding, high levels this metabolite are harmful promote oxidative stress, inflammation, atherosclerosis. In humans, elevated circulating predispose individuals cardiovascular diseases chronic kidney disease increase mortality risk, especially elderly. How exerts its negative effects has been only partially elucidated. hypertensive rats, eNOS substrate L-arginine Taurisolo®, a nutraceutical endowed with TMAO-reducing activity, act synergistically reduce arterial blood pressure. Here, we investigate molecular mechanisms underpinning synergism prove that TMAO, target acts as direct inhibitor endothelial nitric oxide synthase (eNOS) competes at catalytic site, ultimately inhibiting NO production acetylcholine (Ach)-induced relaxation murine aortas.

Language: Английский

Citations

0
The Gut–Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction DOI Open Access
Katherine Rivera, Leticia González,

Liena Bravo

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12465 - 12465

Published: Nov. 20, 2024

Myocardial infarction (MI) remains the leading cause of death globally, imposing a significant burden on healthcare systems and patients. The gut-heart axis, bidirectional network connecting gut health to cardiovascular outcomes, has recently emerged as critical factor in MI pathophysiology. Disruptions this including dysbiosis compromised intestinal barrier integrity, lead systemic inflammation driven by gut-derived metabolites like lipopolysaccharides (LPSs) trimethylamine N-oxide (TMAO), both which exacerbate progression. In contrast, such short-chain fatty acids (SCFAs) from balanced microbiota exhibit protective effects against cardiac damage. This review examines molecular mediators considering role factors sex-specific hormones, aging, diet, physical activity, alcohol consumption outcomes. Additionally, we highlight therapeutic approaches, dietary interventions, personalized probiotics, exercise regimens. Addressing axis holds promise for reducing risk improving recovery, positioning it novel target therapy.

Language: Английский

Citations

3
Low-Molecular-Weight Compounds Produced by the Intestinal Microbiota and Cardiovascular Disease DOI Open Access
Lorena Cuervo, Patrick L. McAlpine, Carlos Olano

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10397 - 10397

Published: Sept. 27, 2024

Cardiovascular disease is the main cause of mortality in industrialized countries, with over 500 million people affected worldwide. In this work, roles low-molecular-weight metabolites originating from gut microbiome, such as short-chain fatty acids, hydrogen sulfide, trimethylamine, phenylacetic acid, secondary bile indoles, different gases, neurotransmitters, vitamins, and complex lipids, are discussed relation to their CVD-promoting or preventing activities. Molecules mixed microbial human hepatic origin, trimethylamine N-oxide phenylacetylglutamine, also presented. Finally, dietary agents cardioprotective effects, probiotics, prebiotics, mono- poly-unsaturated carotenoids, polyphenols, discussed. A special emphasis given microbiota-modulating properties.

Language: Английский

Citations

1
Biomarkers of Importance in Monitoring Heart Condition After Acute Myocardial Infarction DOI Open Access
Aneta Aleksova, Alessandra Lucia Fluca, Antonio Paolo Beltrami

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 129 - 129

Published: Dec. 29, 2024

Despite notable advancements in cardiovascular medicine, morbidity and mortality rates associated with myocardial infarction (MI) remain high. The unfavourable prognosis absence of robust post-MI protocols necessitate further intervention. In this comprehensive review, we will focus on well-established novel biomarkers that can provide insight into the processes occur after an ischemic event. More precisely, during follow-up, it is particular importance to monitor indicate increase stretch stress, damage death cardiomyocytes, remodelling extracellular matrix, oxidative inflammation. This enables identification abnormalities a timely manner, as well capacity respond promptly any changes. Therefore, would like highlight well-known markers, such natriuretic peptides, high-sensitivity troponins, soluble suppression tumorigenicity 2, galactin-3, C-reactive protein, interleukins settings, adrenomedullin, growth differentiation factor-15, insulin-like factor binding protein 7, amyloid beta, vitamin D, trimethylamine N-oxide, advanced glycation end-products recently emerged filed. implementation protocols, which encompass monitoring aforementioned deemed pertinent, conjunction adherence established cardiac rehabilitation programmes, along already therapeutic strategies control risk factors, has potential markedly enhance patient outcomes reduce elevated level mortality.

Language: Английский

Citations

0