Next frontier in cancer treatment: an iPSC supported CAR-T cell therapies DOI Open Access

Tayyaba Sona

Asia-Pacific Journal of Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The spread of cancer and huge number related deaths has made it imperative for scientist to search new diagnostic, prognostic treatment tools its effective management. Chimeric Antigen Receptor (CAR) T-cell (CAR-T) therapy been brought into limelight as novel strategy cancer. In this review we briefly introduced the CAR-T highlighting successful application various cancers along with possibility integrating induced pluripotent stem cell (iPSC) technology overcome intrinsic limitation. mechanism is based on isolation white blood cells through leukapheresis from patients’ or healthy donors followed by T-cells (a type immune cells). isolated are engineered using a viral vector other methods incorporate CAR gene expanded in lab. This modification enables T distinguish attack antigens surfaces cells. However, approach not without inherent limitations. notable limitation exhaustible availability within donor patient system, which can restrict feasibility effectiveness therapeutic intervention. A potential solution may lie synergizing technology. iPSC lies ability provide an endless supply resources. substantial amount research revealed production human Therefore, such combinatorial utilizing mounting immunological against continues iPSCs prove revolutionary designing pragmatic treatment.

Language: Английский

Advances in CRISPR-Cas technology and its applications: revolutionising precision medicine DOI Creative Commons

Sarkar Sardar Azeez,

Rahin Shareef Hamad,

Bahra Kakamin Hamad

et al.

Frontiers in Genome Editing, Journal Year: 2024, Volume and Issue: 6

Published: Dec. 12, 2024

CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated proteins) has undergone marked advancements since its discovery as an adaptive immune system in bacteria and archaea, emerged a potent gene-editing tool after the successful engineering of synthetic guide RNA (sgRNA) toward targeting specific DNA sequences with high accuracy. Besides editing ability, further-developed Cas variants can also edit epigenome, rendering versatile for genome epigenome manipulation pioneering force precision medicine. This review explores latest technology therapeutic biomedical applications, highlighting transformative impact on Moreover, current status CRISPR therapeutics clinical trials is discussed. Finally, we address persisting challenges prospects technology.

Language: Английский

Citations

2
Next frontier in cancer treatment: an iPSC supported CAR-T cell therapies DOI Open Access

Tayyaba Sona

Asia-Pacific Journal of Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The spread of cancer and huge number related deaths has made it imperative for scientist to search new diagnostic, prognostic treatment tools its effective management. Chimeric Antigen Receptor (CAR) T-cell (CAR-T) therapy been brought into limelight as novel strategy cancer. In this review we briefly introduced the CAR-T highlighting successful application various cancers along with possibility integrating induced pluripotent stem cell (iPSC) technology overcome intrinsic limitation. mechanism is based on isolation white blood cells through leukapheresis from patients’ or healthy donors followed by T-cells (a type immune cells). isolated are engineered using a viral vector other methods incorporate CAR gene expanded in lab. This modification enables T distinguish attack antigens surfaces cells. However, approach not without inherent limitations. notable limitation exhaustible availability within donor patient system, which can restrict feasibility effectiveness therapeutic intervention. A potential solution may lie synergizing technology. iPSC lies ability provide an endless supply resources. substantial amount research revealed production human Therefore, such combinatorial utilizing mounting immunological against continues iPSCs prove revolutionary designing pragmatic treatment.

Language: Английский

Citations

0