A Comparative Study of Conventional Pap Smear and Liquid‐Based Cytology DOI Creative Commons
Ekaterina Kldiashvili,

Khuntsaria Irakli,

Kekelia Elene

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

ABSTRACT Background Cervical cancer is a major health issue globally, particularly in developing countries where it remains leading cause of cancer‐related deaths among women. In Georgia, ranks as the fifth most frequent women overall and third aged 15−44 years. Approximately 1.60 million 15 years older Georgia are at risk cervical cancer. Annually, about 327 diagnosed, 204 die from disease. Screening for crucial reducing incidence mortality rates. While conventional Pap smear has been primary screening method, its limitations sensitivity sample adequacy have led to development liquid‐based cytology (LBC). Materials Methods This study analyzed 1000 samples 18−65 who were gynecologically asymptomatic not vaccinated HPV. The median age was 37 Informed consent obtained all participants. Samples collected using ThinPrep reagents (Hologic) processed within 2 h. Smears prepared 2000 Processor, fixed absolute alcohol 30 min, stained according Papanicolaou protocol. Bethesda 2001 System terminology used reporting. evaluated by light microscopy archived per Georgian medical data requirements. Results found significant differences between two methods. LBC showed higher rate satisfactory smears better detection rates negative intraepithelial lesion or malignancy—NILM (89.4% vs. 80.3% smear). Unsatisfactory significantly lower with (1.33% 7.33%). Detection atypical squamous cells undetermined significance (ASCUS), cells, cannot exclude high grade (ASC‐H), low (LSIL), (HSIL) also improved LBC, indicating diagnostic accuracy. Conclusion outperforms providing adequacy, rates, greater Implementing more widely could enhance early reduce mortality, high‐risk populations. These findings support adoption superior method clinical practice.

Language: Английский

The Relationship Between Cervicovaginal Infection, Human Papillomavirus Infection and Cervical Intraepithelial Neoplasia in Romanian Women DOI Creative Commons

Anca Daniela Brăila,

Cristian-Viorel Poalelungi,

Cristina-Crenguța Albu

et al.

Diseases, Journal Year: 2025, Volume and Issue: 13(1), P. 18 - 18

Published: Jan. 16, 2025

Cervical intraepithelial neoplasia (CIN) is a premalignant cervical condition closely linked to persistent high-risk HPV infection, major risk factor for cancer. This study aims investigate the relationship between cervicovaginal infections, and CIN development in 94 Romanian women with lesions. Comprehensive assessments included genotyping, cytology, colposcopy, histopathology. In 53.20% of cases, vaginal infections were identified, Candida albicans most frequently associated HPV. Histopathology revealed 48.94% low-grade CIN, 42.55% high-grade 8.51% invasive carcinoma. There was strong correlation types (especially 16 18), colposcopic findings, histopathology, age. emphasizes mutual effect infection increasing developing cancer among women. Persistent types, particularly 18, has been confirmed as primary driver progression.

Language: Английский

Citations

2
A Comparative Study of Conventional Pap Smear and Liquid‐Based Cytology DOI Creative Commons
Ekaterina Kldiashvili,

Khuntsaria Irakli,

Kekelia Elene

et al.

Health Science Reports, Journal Year: 2025, Volume and Issue: 8(4)

Published: April 1, 2025

ABSTRACT Background Cervical cancer is a major health issue globally, particularly in developing countries where it remains leading cause of cancer‐related deaths among women. In Georgia, ranks as the fifth most frequent women overall and third aged 15−44 years. Approximately 1.60 million 15 years older Georgia are at risk cervical cancer. Annually, about 327 diagnosed, 204 die from disease. Screening for crucial reducing incidence mortality rates. While conventional Pap smear has been primary screening method, its limitations sensitivity sample adequacy have led to development liquid‐based cytology (LBC). Materials Methods This study analyzed 1000 samples 18−65 who were gynecologically asymptomatic not vaccinated HPV. The median age was 37 Informed consent obtained all participants. Samples collected using ThinPrep reagents (Hologic) processed within 2 h. Smears prepared 2000 Processor, fixed absolute alcohol 30 min, stained according Papanicolaou protocol. Bethesda 2001 System terminology used reporting. evaluated by light microscopy archived per Georgian medical data requirements. Results found significant differences between two methods. LBC showed higher rate satisfactory smears better detection rates negative intraepithelial lesion or malignancy—NILM (89.4% vs. 80.3% smear). Unsatisfactory significantly lower with (1.33% 7.33%). Detection atypical squamous cells undetermined significance (ASCUS), cells, cannot exclude high grade (ASC‐H), low (LSIL), (HSIL) also improved LBC, indicating diagnostic accuracy. Conclusion outperforms providing adequacy, rates, greater Implementing more widely could enhance early reduce mortality, high‐risk populations. These findings support adoption superior method clinical practice.

Language: Английский

Citations

0