Unveiling new perspectives about the onset of neurological and cognitive deficits in cerebral malaria: exploring cellular and neurochemical mechanisms

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: Feb. 6, 2025

Cerebral malaria is the most severe and lethal complication caused by Plasmodium falciparum infection, leading to critical neurological impairments long-term cognitive, behavioral, sequelae in survivors, particularly affecting children under age of five. Various hypotheses have been proposed explain syndrome associated cerebral condition, including vascular occlusion sequestration, cytokine storm or inflammatory response, a combination these mechanisms despite extensive research growing range scientific information, precise pathophysiological mechanism remains poorly understood. In this sense, review aims explore impairment elucidate novel severity disease. Recent evidence implicates glutamate glutamatergic pathways onset malaria, alongside metabolic activity other molecules such as dopamine kynurenic acid. These neurotransmitters may play crucial role pathogenesis potentially interacting with molecular players. By enhancing our understanding pathophysiology article seeks new regarding involvement their interactions targets, thereby contributing overall pathology malaria.

Language: Английский

Substantial growth of Health Sciences Review

Health Sciences Review, Journal Year: 2024, Volume and Issue: 11, P. 100182 - 100182

Published: June 1, 2024

Language: Английский