Pulsed Alternating Fields Magnetic Hyperthermia in Combination with Chemotherapy (5-Fluorouracil) as a Cancer Treatment for Glioblastoma Multiform: An In Vitro Study DOI Creative Commons
Lilia Souiade, María Rodriguez-Garcia, José Javier Serrano Olmedo

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 556 - 556

Published: April 5, 2025

Inducing magnetic hyperthermia (MHT) involves locally raising the temperature to 39–45 °C, which increases susceptibility of tumor cells therapeutic agents without damaging healthy tissues. Recent studies on trapezoidal pulsed alternating fields (TP-AMFs) have proven their considerable efficacy in increasing nanoparticles (MNPs) compared sinusoidal fields. Thermal therapies been known incorporate multiple combinations approaches optimize medical procedure for healing cancer patients such as chemotherapy and radiotherapy. The combination MHT with aims enhance effects against due synergistic interaction cells. In this study, we aim exploit combining produced by TP-AMFs a low concentration 5-Fluorouracil (5-FU) outcomes comparison alone. Hence, exposed glioblastoma cell line (CT2A) incubated iron oxide at 1 mg/mL two cycles employing trapezoidal-square waveform 200 kHz 2 mT 30 min each cycle, separated 45 break, both single treatment 0.1 μg/mL 5-FU. Our findings demonstrated effect between via 5-FU, death 58.9 ± 2%, 31.4 3% Cell was primarily driven necrosis pathway (47.3 2%) apoptosis (11.6 2). addition 5-FU enhanced cytotoxic CT2A cells, calreticulin (CRT) positive 17 1% 10 Furthermore, suggests that employed approach can promote immune system activation exposure CRT treated

Language: Английский

A Compendium of Magnetic Nanoparticle Essentials: A Comprehensive Guide for Beginners and Experts DOI Creative Commons
Carlos O. Amorim

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 137 - 137

Published: Jan. 20, 2025

Magnetic nanoparticles (MNPs) are advanced materials that combine the unique properties of magnetic and nanoscale dimensions, enabling a wide range applications in biomedicine, environmental science, information technology. This review provides comprehensive yet accessible introduction to fundamental principles, characterization techniques, diverse MNPs, with focus on their properties, such as superparamagnetism, single-domain behavior, surface effects. It also delves into classification critical role parameters like anisotropy blocking temperature. Emphasis is placed routine methods, including X-ray diffraction, electron microscopy, magnetometry, well concepts hyperthermia self-regulated heating. Designed for newcomers experts alike, this serves both an educational guide quick-reference resource, ensuring clarity while maintaining scientific rigor.

Language: Английский

Citations

0
Pulsed Alternating Fields Magnetic Hyperthermia in Combination with Chemotherapy (5-Fluorouracil) as a Cancer Treatment for Glioblastoma Multiform: An In Vitro Study DOI Creative Commons
Lilia Souiade, María Rodriguez-Garcia, José Javier Serrano Olmedo

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 556 - 556

Published: April 5, 2025

Inducing magnetic hyperthermia (MHT) involves locally raising the temperature to 39–45 °C, which increases susceptibility of tumor cells therapeutic agents without damaging healthy tissues. Recent studies on trapezoidal pulsed alternating fields (TP-AMFs) have proven their considerable efficacy in increasing nanoparticles (MNPs) compared sinusoidal fields. Thermal therapies been known incorporate multiple combinations approaches optimize medical procedure for healing cancer patients such as chemotherapy and radiotherapy. The combination MHT with aims enhance effects against due synergistic interaction cells. In this study, we aim exploit combining produced by TP-AMFs a low concentration 5-Fluorouracil (5-FU) outcomes comparison alone. Hence, exposed glioblastoma cell line (CT2A) incubated iron oxide at 1 mg/mL two cycles employing trapezoidal-square waveform 200 kHz 2 mT 30 min each cycle, separated 45 break, both single treatment 0.1 μg/mL 5-FU. Our findings demonstrated effect between via 5-FU, death 58.9 ± 2%, 31.4 3% Cell was primarily driven necrosis pathway (47.3 2%) apoptosis (11.6 2). addition 5-FU enhanced cytotoxic CT2A cells, calreticulin (CRT) positive 17 1% 10 Furthermore, suggests that employed approach can promote immune system activation exposure CRT treated

Language: Английский

Citations

0