Association between TMPRSS2 rs2070788 polymorphism and COVID-19 severity: a case-control study in multiple cities of Iran DOI Creative Commons
Arezoo Faridzadeh, Mahmoud Mahmoudi,

Bahman Rahimlou

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 12, 2024

Introduction Host genetic variations have been identified as potential influencers of COVID-19 infection. This study aimed to examine the association between transmembrane serine protease type 2 ( TMPRSS2 ) rs2070788 single nucleotide polymorphism (SNP) and prognosis in Iranian populations. Method case-control was performed on 756 patients 59 healthy individuals across Iran. Clinical data, blood samples, presence rs2070788: G>A SNP were determined using T-ARMS-PCR. Additionally, serum levels tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β evaluated collected samples. Results No significant found genotypes allele frequencies susceptibility or mortality from However, we observed a substantial increase IL-6 CRP associated with severity COVID-19, while no such trend for TNF-α. showed considerable rise TNF-α exclusively TT genotype compared controls. Conclusion In this conducted multiple cities Iran, mortality.

Language: Английский

Association between TMPRSS2 rs2070788 polymorphism and COVID-19 severity: a case-control study in multiple cities of Iran DOI Creative Commons
Arezoo Faridzadeh, Mahmoud Mahmoudi,

Bahman Rahimlou

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: Aug. 12, 2024

Introduction Host genetic variations have been identified as potential influencers of COVID-19 infection. This study aimed to examine the association between transmembrane serine protease type 2 ( TMPRSS2 ) rs2070788 single nucleotide polymorphism (SNP) and prognosis in Iranian populations. Method case-control was performed on 756 patients 59 healthy individuals across Iran. Clinical data, blood samples, presence rs2070788: G>A SNP were determined using T-ARMS-PCR. Additionally, serum levels tumor necrosis factor α (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), IL-1β evaluated collected samples. Results No significant found genotypes allele frequencies susceptibility or mortality from However, we observed a substantial increase IL-6 CRP associated with severity COVID-19, while no such trend for TNF-α. showed considerable rise TNF-α exclusively TT genotype compared controls. Conclusion In this conducted multiple cities Iran, mortality.

Language: Английский

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