Promising Cellular Immunotherapy for Colorectal Cancer Using Classical Dendritic Cells and Natural Killer T Cells DOI Creative Commons
Mahmoud Singer,

Jennifer Valerin,

Zhuoli Zhang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 166 - 166

Published: Jan. 22, 2025

Colorectal cancer (CRC) remains one of the leading causes cancer-related morbidity and mortality around world. Despite advances in surgery, chemotherapy, targeted therapies, prognosis for patients with metastatic or advanced CRC poor. Immunotherapies comprising immune checkpoint inhibitors showed disappointing responses (mCRC). However, cellular immunotherapy, specifically using classical dendritic cells (cDCs), may hold unique promise recognition antigens. cDCs are substantial players instrumental orchestrating innate adaptive by processing presenting tumor antigens to effector cells. Natural killer T (NKT) insufficiently studied but because their ability bridge reactions crosstalk cancer. This review explores therapeutic potential both NKT as a synergistic therapy CRC, focusing on biological roles, strategies harnessing capabilities, clinical applications, challenges within microenvironment. Both can be used new effective approach cell-based therapies cancers provide hope that challenging treat.

Language: Английский

Promising Cellular Immunotherapy for Colorectal Cancer Using Classical Dendritic Cells and Natural Killer T Cells DOI Creative Commons
Mahmoud Singer,

Jennifer Valerin,

Zhuoli Zhang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 166 - 166

Published: Jan. 22, 2025

Colorectal cancer (CRC) remains one of the leading causes cancer-related morbidity and mortality around world. Despite advances in surgery, chemotherapy, targeted therapies, prognosis for patients with metastatic or advanced CRC poor. Immunotherapies comprising immune checkpoint inhibitors showed disappointing responses (mCRC). However, cellular immunotherapy, specifically using classical dendritic cells (cDCs), may hold unique promise recognition antigens. cDCs are substantial players instrumental orchestrating innate adaptive by processing presenting tumor antigens to effector cells. Natural killer T (NKT) insufficiently studied but because their ability bridge reactions crosstalk cancer. This review explores therapeutic potential both NKT as a synergistic therapy CRC, focusing on biological roles, strategies harnessing capabilities, clinical applications, challenges within microenvironment. Both can be used new effective approach cell-based therapies cancers provide hope that challenging treat.

Language: Английский

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