Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(35), P. 2753 - 2764
Published: Aug. 2, 2024
Microemulsion
gel,
as
a
promising
transdermal
nanoparticle
delivery
system,
addresses
the
limitations
of
microemulsions
and
enhances
their
performance
in
drug
release.
This
article
aims
to
discuss
advantages
microemulsion
including
improved
bioavailability,
reduced
irritation,
enhanced
penetration
skin
adhesion,
increased
antimicrobial
properties.
It
explores
methods
for
selecting
formulations
general
processes
preparation,
well
commonly
used
oil
phases,
surfactants,
co-surfactants.
Additionally,
biomedical
applications
gel
treating
conditions,
such
acne
psoriasis,
are
also
discussed.
Overall,
this
elucidates
significant
potential
topical
delivery,
providing
insights
into
future
development
clinical
applications.
Discover Nano,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: Oct. 4, 2024
Nanomedicine
has
the
potential
to
transform
healthcare
by
offering
targeted
therapies,
precise
diagnostics,
and
enhanced
drug
delivery
systems.
The
National
Institutes
of
Health
coined
term
"nanomedicine"
describe
use
nanotechnology
in
biological
system
monitoring,
control,
diagnosis,
treatment.
continues
receive
increasing
interest
for
rationalized
therapeutics
pharmaceutical
agents
achieve
required
response
while
reducing
its
side
effects.
However,
as
advance,
concerns
about
toxicological
effects
have
also
grown.
This
review
explores
current
state
nanomedicine,
focusing
on
types
nanoparticles
used
their
associated
properties
that
contribute
nanotoxicity.
It
examines
mechanisms
through
which
exert
toxicity,
encompassing
various
cellular
molecular
interactions.
Furthermore,
it
discusses
assessment
methods
employed
evaluate
nanotoxicity,
in-vitro
in-vivo
models,
well
emerging
techniques.
addresses
regulatory
issues
surrounding
nanotoxicology,
highlighting
challenges
developing
standardized
guidelines
ensuring
secure
translation
nanomedicine
into
clinical
settings.
ethical
with
understanding
safety
profile
is
essential
effective
therapeutic
applications.
Discover Nano,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 16, 2025
Abstract
Phytonanoparticles
have
emerged
as
a
promising
class
of
biomaterials
for
enhancing
bone
regeneration
and
osseointegration,
offering
unique
advantages
in
biocompatibility,
multifunctionality,
sustainability.
This
comprehensive
review
explores
the
synthesis,
characterization,
applications
phytonanoparticles
tissue
engineering.
The
green
synthesis
approach,
utilizing
plant
extracts
reducing
stabilizing
agents,
yields
nanoparticles
with
intrinsic
bioactive
properties
that
can
synergistically
promote
osteogenesis.
We
examine
mechanisms
by
which
phytonanoparticles,
particularly
those
derived
from
gold,
silver,
zinc
oxide,
influence
key
molecular
pathways
osteogenesis,
including
RUNX2
Osterix
signaling.
discusses
advanced
strategies
phyto-nanoparticle
design,
such
surface
functionalization
stimuli-responsive
release
mechanisms,
enhance
their
efficacy
applications.
Preclinical
studies
demonstrating
improved
osteoblast
proliferation,
differentiation,
mineralization
are
critically
analyzed,
along
emerging
clinical
data.
Despite
results,
scalability,
standardization,
regulatory
approval
challenges
persist.
also
addresses
economic
environmental
implications
production.
Looking
ahead,
we
identify
research
directions,
developing
personalized
therapies,
combination
approaches
stem
cells
or
gene
delivery,
long-term
safety
assessments.
By
harnessing
power
plant-derived
nanomaterials,
represent
an
innovative
approach
to
addressing
complex
regeneration,
potential
spanning
dental,
orthopedic,
maxillofacial
surgery.
Graphical
abstract
