Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(35), P. 2753 - 2764
Published: Aug. 2, 2024
Microemulsion
gel,
as
a
promising
transdermal
nanoparticle
delivery
system,
addresses
the
limitations
of
microemulsions
and
enhances
their
performance
in
drug
release.
This
article
aims
to
discuss
advantages
microemulsion
including
improved
bioavailability,
reduced
irritation,
enhanced
penetration
skin
adhesion,
increased
antimicrobial
properties.
It
explores
methods
for
selecting
formulations
general
processes
preparation,
well
commonly
used
oil
phases,
surfactants,
co-surfactants.
Additionally,
biomedical
applications
gel
treating
conditions,
such
acne
psoriasis,
are
also
discussed.
Overall,
this
elucidates
significant
potential
topical
delivery,
providing
insights
into
future
development
clinical
applications.
Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(32), P. 2524 - 2537
Published: July 11, 2024
Many
brain
diseases
pose
serious
challenges
to
human
life.
Alzheimer's
Disease
(AD)
and
Parkinson's
(PD)
are
common
neurodegenerative
that
seriously
threaten
health.
Glioma
is
a
malignant
tumor.
However,
drugs
cannot
cross
physiological
pathological
barriers
most
therapeutic
enter
the
because
of
presence
Blood-brain
Barrier
(BBB)
Bloodbrain
Tumor
(BBTB).
How
enable
penetrate
BBB
brain,
reduce
systemic
toxicity,
BBTB
exert
effects
has
become
challenge.
Nanosuspension
can
successfully
formulate
difficult
dissolve
in
water
oil
by
using
surfactants
as
stabilizers,
which
suitable
for
target
delivery
class
II
IV
Biopharmaceutical
Classification
System
(BCS).
In
nanosuspension
drug
systems,
physical
properties
nanostructures
have
great
impact
on
accumulation
at
site,
such
brain.
Optimizing
parameters
improve
efficiency
disease
treatment.
Therefore,
key
challenges,
influencing
factors,
future
perspectives
enhancing
summarized
reviewed
here.
This
article
aims
provide
better
understanding
formulation
technology
used
strategies
overcome
various
barriers.
Current Pharmaceutical Design,
Journal Year:
2024,
Volume and Issue:
30(35), P. 2753 - 2764
Published: Aug. 2, 2024
Microemulsion
gel,
as
a
promising
transdermal
nanoparticle
delivery
system,
addresses
the
limitations
of
microemulsions
and
enhances
their
performance
in
drug
release.
This
article
aims
to
discuss
advantages
microemulsion
including
improved
bioavailability,
reduced
irritation,
enhanced
penetration
skin
adhesion,
increased
antimicrobial
properties.
It
explores
methods
for
selecting
formulations
general
processes
preparation,
well
commonly
used
oil
phases,
surfactants,
co-surfactants.
Additionally,
biomedical
applications
gel
treating
conditions,
such
acne
psoriasis,
are
also
discussed.
Overall,
this
elucidates
significant
potential
topical
delivery,
providing
insights
into
future
development
clinical
applications.
