In vitro assessment of the osteogenic and antibacterial capabilities of Mg-MOF particles with encapsulated levofloxacin within polydopamine

Published: April 10, 2025

Infectious bone defect is a condition where infection and occur simultaneously. The simultaneous achievement of effective antimicrobial management enhanced regeneration continues to present major hurdle in musculoskeletal therapeutics. To address these limitations, we have developed novel osteoconductive material, this material (PDA@Mg-MOF-LEV) consists Magnesium-based metal-organic frameworks (Mg-MOF) particles loaded with the antibiotic levofloxacin (LEV) coated polydopamine (PDA), which integrates photothermal therapy delivery combat bacterial drug resistance facilitate tissue regeneration. Under near-infrared (NIR) irradiation, PDA@Mg-MOF-LEV demonstrate superior antibacterial efficacy osteogenic potential. Drug release studies indicate that NIR irradiation significantly increases LEV by 337% Mg ions 196% compared standard conditions. Furthermore, vitro assays confirm markedly enhances activity particles, achieving inhibition rates 97.5 ± 1.45% against Escherichia coli (E. coli) 98.5 2.27% Staphylococcus aureus (S. aureus). mediated not only but also directly stimulates differentiation calcium deposition mBMSCs, positioning as multi-modal therapeutic platform for infective osteogenesis.

Language: Английский

Synthesis of nanoparticles using advanced techniques

Next Nanotechnology, Journal Year: 2025, Volume and Issue: 8, P. 100169 - 100169

Published: Jan. 1, 2025

Language: Английский