Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties

Phytomedicine, Journal Year: 2023, Volume and Issue: 122, P. 155150 - 155150

Published: Oct. 15, 2023

Language: Английский

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Genus Sambucus: Exploring Its Potential as a Functional Food Ingredient with Neuroprotective Properties Mediated by Antioxidant and Anti-Inflammatory Mechanisms

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7843 - 7843

Published: July 18, 2024

The genus Sambucus, mainly Sambucus nigra, has emerged as a valuable source of bioactive compounds with potential neuroprotective properties. This review explores the antioxidant, anti-inflammatory, and neuroregenerative effects Sambucus-derived their implications for brain health cognitive function. In vitro studies have demonstrated ability extracts to mitigate oxidative stress, modulate inflammatory responses, promote neural stem cell proliferation differentiation. vivo using animal models neurodegenerative diseases, such Alzheimer’s Parkinson’s, shown that can improve function, motor performance, neuronal survival while attenuating neuroinflammation damage. are primarily attributed its rich content polyphenols, particularly anthocyanins, which exert benefits through multiple mechanisms, including modulation signaling pathways involved in inflammation, apoptosis, mitochondrial stress. Furthermore, functional food ingredient is discussed, highlighting application various products challenges associated stability bioavailability compounds. provides comprehensive overview current state research on derivatives, offering insights development dietary strategies prevent age-related decline.

Language: Английский

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Molecular Mechanisms Underlying Neuroinflammation Intervention with Medicinal Plants: A Critical and Narrative Review of the Current Literature

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(1), P. 133 - 133

Published: Jan. 20, 2025

Neuroinflammation is a key factor in the progression of neurodegenerative diseases, driven by dysregulation molecular pathways and activation brain’s immune system, resulting release pro-inflammatory oxidative molecules. This chronic inflammation exacerbated peripheral leukocyte infiltration into central nervous system. Medicinal plants, with their historical use traditional medicine, have emerged as promising candidates to mitigate neuroinflammation offer sustainable alternative for addressing conditions green healthcare framework. review evaluates effects medicinal plants on neuroinflammation, emphasizing mechanisms action, effective dosages, clinical implications, based systematic search databases such PubMed, SCOPUS, Web Science. The findings highlight that like Cleistocalyx nervosum var. paniala, Curcuma longa, Cannabis sativa, Dioscorea nipponica reduce cytokines (TNF-α, IL-6, IL-1β), inhibit enzymes (COX-2 iNOS), activate antioxidant pathways, particularly Nrf2. NF-κB primary pathway inhibited across studies. While anti-inflammatory potential these significant, variability dosages phytochemical compositions limits translation. Here, we are modulators underscoring therapeutic potential. Future research should focus animal models, standardized protocols, safety assessments, integrating advanced methodologies, genetic studies nanotechnology, enhance applicability disease management.

Language: Английский

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Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Language: Английский

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Natural products in neurodegenerative diseases: recent advances and future outlook

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s are on the rise pose significant challenges due to lack of effective treatments. This review critically examines neuroprotective effects various natural products derived from plants, marine organisms, fungi. Natural have long been used in traditional medicine gaining attention modern drug discovery for their unique properties. The explains how these can protect neurons by influencing key biological pathways involved neurodegeneration. It discusses mechanisms including antioxidant effects, anti-inflammatory actions, modulation cellular signalling, support mitochondrial function. A systematic literature search was conducted minimize bias ensure rigorous study selection. Preclinical studies using animal models cell cultures show that secondary metabolites like polyphenols, alkaloids, terpenoids significantly reduce neuronal damage. Some clinical trials shown promising results. However, bioavailability, standardization, dosage must be addressed translate findings into practice. also evaluates potential synergy combining with conventional treatments, offering a complementary therapeutic approach. represent avenue developing innovative treatments neurodegenerative diseases. highlights research gaps proposes future directions. Future should focus overcoming existing refining improve efficacy safety settings. application knowledge has enhance quality life individuals affected

Language: Английский

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Neuroprotective Effects of Dendrobium nobile

CABI eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 198 - 217

Published: March 24, 2025

Language: Английский

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Unlocking New Pharma/Nutraceutical Frontiers With Neuroprotective Properties of Three Hypericum Species: A Study Combination With In Vitro and In Silico Methodologies

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT This study investigates the phytochemical composition and biopharmacological potential of three Hypericum species ( H. scabrum , lysimachioides uniglandulosum ) from Turkey. Aqueous hydroalcoholic extracts were analyzed for their total phenolic content (TPC), flavonoid (TFC), individual components (by UHPLC–HRMS technique). Antioxidant activities investigated by DPPH, ABTS, CUPRAC, FRAP, phosphomolybdenum, metal chelating assays. The inhibition effects tested on acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, amylase, glucosidase examined. One hundred compounds identified in chemical composition, specific genus such as hyperoside, hypericin, pseudohypericin, detected. highest TPC was detected ethanol/water extract with 69.21 mg GAE/g. Furthermore, showed strongest free radical reducing effect. more active than water extracts. Neuroprotective assessments indicated downregulation COX‐2 NOS‐2 genes LPS‐stimulated mouse cortex models, alongside modulation SERT NET expression, suggesting reduced neuroinflammation enhanced neurotransmitter release. Molecular docking dynamics analyses highlighted strong binding interactions, especially NET_hyperoside NET_myricitrin complexes. results indicate significant therapeutic these extracts, supporting development natural agents against oxidative stress, neuroinflammation, related neurodegenerative diseases.

Language: Английский

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Autophagy and UPS pathway contribute to nicotine-induced protection effect in Parkinson’s disease

Experimental Brain Research, Journal Year: 2024, Volume and Issue: 242(4), P. 971 - 986

Published: March 2, 2024

Language: Английский

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Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health

Foods, Journal Year: 2024, Volume and Issue: 13(7), P. 1118 - 1118

Published: April 6, 2024

Clovamide (N-caffeoyl-L-3,4-dihydroxyphenylalanine, N-caffeoyldopamine, N-caffeoyl-L-DOPA) is a derivative of caffeic acid, belonging to phenolamides (hydroxycinnamic acid amides). Despite growing interest in the biological activity natural polyphenolic substances, studies on properties clovamide and related compounds, their significance as bioactive components diet, well effects human health are relatively new research trend. On other hand, vitro vivo evidence indicates considerable potential these substances context maintaining or using them pharmacophores. The name “clovamide” directly derives from red clover (Trifolium pratense L.), being first identified source this compound. In clovamides mainly present chocolate cocoa-containing products. Furthermore, occurrence some medicinal plants has also been confirmed. literature reports deal with antioxidant, anti-inflammatory, neuroprotective, antiplatelet/antithrombotic anticancer clovamide-type compounds. This narrative review summarizes available data health-supporting properties, including prospects for use compounds therapeutic purposes.

Language: Английский

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Asiaticasics A-O, structurally intriguing coumarins from Toddalia asiatica with potential inflammatory inhibitory activity

Phytochemistry, Journal Year: 2024, Volume and Issue: 221, P. 114042 - 114042

Published: Feb. 28, 2024

Language: Английский

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