International Journal of Physiology Pathophysiology and Pharmacology,
Journal Year:
2024,
Volume and Issue:
16(6), P. 126 - 137
Published: Jan. 1, 2024
The
significant
correlation
between
acute
myocardial
infarction
and
subsequent
hepatorenal
dysfunction
could
result
in
a
higher
mortality
rate
patients.
study
aimed
to
evaluate
the
effect
mechanisms
of
coenzyme-Q10
(Q10)
administration
on
an
isoprenaline
(ISO)-induced
model
rats.
Twenty
male
rats
were
assigned
into
four
groups
(n
=
5).
Groups
1-2
administered
intraperitoneally
with
normal
saline,
3-4
pretreated
Q10
(10
mg/kg,
i.p.)
for
28
days,
2
4
received
ISO
(200
last
two
days.
Body,
kidney,
liver
weights,
antioxidants
biochemical
biomarkers,
histopathological
investigation
kidney
tissues
performed.
significantly
(P
<
0.05)
increased
oxidative
stress
altered
renal
function
integrity
morphology.
Pretreatment
demonstrated
protective
against
histological
alterations
through
enhanced
antioxidant
actions,
notably
increasing
levels
superoxide
dismutase,
catalase,
glutathione,
glutathione
transferase;
reduced
enzymes
(aspartate
transaminase,
aspartate
aminotransferase,
alkaline
phosphatase,
lactate
dehydrogenase),
decreased
urea
creatinine
concentrations
gravity
histomorphological
changes
hepatic
treated
Overall,
our
suggests
that
confers
protection
ISO-induced
accompanying
its
effects
amelioration
fibrotic
changes.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 7, 2024
Abstract
Most
research
has
not
been
done
on
the
possible
relationship
between
pregnant
women'
cross-metal
exposures
and
postpartum
neuroendocrine
functions.
The
purpose
of
this
study
was
to
look
into
how
co-exposure
aluminium
chloride
(AlCl3)
cadmium
(CdCl2)
affected
neurometabolic
changes
in
mice
A
total
24
adult
female
were
used
for
study.
Group
1
comprised
(n
=
6)
treated
with
AlCl
3
(10mg/kg),
group
2;
CdCl
2
(1.5mg/kg),
a
combination
(10
mg/kg)
(1.5
4
served
as
control.
Oral
treatment
animals
daily
from
gestation
day
7
20.
Upon
delivery
weaning
postnatal
21
(PND
21),
behavioural
assessment
immediately
followed
by
sacrifice
histological
markers.
Our
findings
revealed
that
brain-to-body
weight
ratio
brain
oxidative
stress
elevated
exposed
during
pregnancy.
Given
strong
association
hyperactivity,
social
interaction
index,
catalase,
acetylcholinesterase
activity,
brain/body
ratio,
it
is
plausible
these
effects
have
played
role
adverse
abnormalities
observed
maternal
mice.
Moreover,
noted
certain
situations,
co-exposures
metals
tended
opposite
single
metal
exposures.
International Journal of Physiology Pathophysiology and Pharmacology,
Journal Year:
2024,
Volume and Issue:
16(6), P. 126 - 137
Published: Jan. 1, 2024
The
significant
correlation
between
acute
myocardial
infarction
and
subsequent
hepatorenal
dysfunction
could
result
in
a
higher
mortality
rate
patients.
study
aimed
to
evaluate
the
effect
mechanisms
of
coenzyme-Q10
(Q10)
administration
on
an
isoprenaline
(ISO)-induced
model
rats.
Twenty
male
rats
were
assigned
into
four
groups
(n
=
5).
Groups
1-2
administered
intraperitoneally
with
normal
saline,
3-4
pretreated
Q10
(10
mg/kg,
i.p.)
for
28
days,
2
4
received
ISO
(200
last
two
days.
Body,
kidney,
liver
weights,
antioxidants
biochemical
biomarkers,
histopathological
investigation
kidney
tissues
performed.
significantly
(P
<
0.05)
increased
oxidative
stress
altered
renal
function
integrity
morphology.
Pretreatment
demonstrated
protective
against
histological
alterations
through
enhanced
antioxidant
actions,
notably
increasing
levels
superoxide
dismutase,
catalase,
glutathione,
glutathione
transferase;
reduced
enzymes
(aspartate
transaminase,
aspartate
aminotransferase,
alkaline
phosphatase,
lactate
dehydrogenase),
decreased
urea
creatinine
concentrations
gravity
histomorphological
changes
hepatic
treated
Overall,
our
suggests
that
confers
protection
ISO-induced
accompanying
its
effects
amelioration
fibrotic
changes.
