ChemistrySelect,
Journal Year:
2023,
Volume and Issue:
8(45)
Published: Dec. 1, 2023
Abstract
Two
bimetallic
Fe(II)‐Cu(I)
complexes,
with
tetrahedral
Cu(I)
center
stabilized
in
a
S2P2
environment,
were
synthesized
and
fully
characterized
using
single
crystal
X‐ray
diffraction,
multinuclear
NMR,
IR
UV‐Visible
spectroscopy
techniques.
Density
functional
theory
PBE0‐D3(BJ)
was
employed
to
elucidate
the
electronic
features
of
these
novel
metal
complexes.
The
computational
analysis
revealed
that
while
all
complexes
adopted
geometry
gas
phase
shorter
P−Cu(I)
bonds
than
S−Cu(I)
bonds.
These
cationic
highly
active
catalytic
cycloaddition
reaction
azides
onto
terminal
alkynes.
CuAAC
carried
out
at
room
temperature
as
low
1
mg
(0.1
mol
%)
catalyst
loading
deliver
high
yields
corresponding
1,4
adducts
1,2,3‐triazoles
water
under
aerobic
conditions.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Jan. 2, 2024
Abstract
Treatment
of
[CuCl
2
(PPh
3
)
]
with
N‐heterocyclic
thiols,
i.
e.,
4,6‐dimethyl
pyrimidine‐2‐thiol
(dmpymSH),
pyridine‐2‐thiol
(pySH),
resulted
partially
substituted
product
[CuCl(L)(PPh
(L=C
5
H
4
NSH
SC
H(4,6‐Me
N
H)
(dmpymSH).
However,
similar
reaction
[CuI(PPh
)]
yielded
a
products
[CuI(pySH)(PPh
(py=C
N)
and
[CuI(dmpymSH)(PPh
(dmpym=C
);
respectively.
The
molecular
structure
complex
[CuCl(dmpymSH)(PPh
].CH
CN
(
1
b
has
been
determined
through
the
single
crystal
X‐ray
crystallography
technique.
All
synthesized
complexes
were
fully
characterized
various
spectroscopic
techniques
(IR,
H,
13
C{
H},
31
P{
H}
NMR).
,
showed
excellent
catalytic
activities
for
azide‐alkyne
cycloaddition
in
water
as
green
solvent
upto
90
%
yield
0.5
mol
catalyst
loading.
Among
all
complexes,
compound
turned
up
better
yield,
applying
catalyst.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(47), P. 46860 - 46878
Published: Nov. 16, 2024
The
new
dibenzoazepine-substituted
triazole
hybrids
(12–20)
were
designed
by
molecular
hybridization
approach
and
synthesized
utilizing
the
Cu(I)-catalyzed
click
reaction.
hybrid
structures
obtained
in
high
yields
(74–98%)
with
a
simple
two-step
synthesis
strategy
fully
characterized.
These
compounds
assessed
for
their
influence
on
various
metabolic
enzymes
including
human
carbonic
anhydrase
isoenzymes
(hCA
I
hCA
II),
acetylcholinesterase
(AChE),
butyrylcholinesterase
(BChE).
Ki
values
concerning
I,
II,
AChE,
BChE
ranges
29.94–121.69,
17.72–89.42,
14.09–44.68,
1.15–48.82
nM,
respectively.
Compound
13
was
49.70-fold
more
active
than
tacrine
(standard
drug)
5.49-fold
AChE.
14
4.16-fold
acetazolamide
5.79-fold
II.
cytotoxic
effects
of
products
investigated
triple-negative
breast
cancer
cell
lines.
IC50
most
effective
calculated
between
12.51
±
1.92
18.07
2.14
μM
MDA-MB-231
BT-549
cells.
Molecular
docking
ADME
predictions
performed.
Then,
vitro
analyzed
dynamics
(MD)
simulation
MM/GBSA
calculation.
Consequently,
showed
good
cytotoxicity
inhibition
potential
colony
formation
Beilstein Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
16, P. 551 - 586
Published: April 1, 2020
In
recent
years,
many
inorganic
silica/carbon-based
and
magnetic
materials
have
been
selected
to
arrest
copper
ions
through
a
widespread
range
of
anchoring
embedding
methodologies.
These
supported
nanocatalysts
found
be
efficient,
environmentally
friendly,
recyclable,
durable.
addition,
one
the
vital
issues
for
expanding
new,
stable,
reusable
catalysts
is
discovery
unique
catalysts.
The
basis
foundation
this
review
article
consider
recently
published
developments
(2014–2019)
in
synthesis
catalytic
applications
by
silica
nanocomposites,
carbon
nanocomposites
“click”
chemistry.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(6)
Published: May 2, 2025
ABSTRACT
This
study
discusses
the
development
of
an
effective
and
environmentally
friendly
C‐H
oxidation
process
for
creation
oxygenated
compounds
in
presence
tert
‐butyl
hydroperoxide
by
a
magnetically
recoverable
Fe
3
O
4
@SiO
2
‐FeL
Bpn
nanocomposite.
L
stands
deprotonated,
pyridine‐based,
four‐dentate,
bispicen
ligand.
The
synthesised
catalyst
was
characterised
Fourier‐transform
infrared
spectroscopy
(FTIR),
energy‐dispersive
X‐ray
analysis
(EDX),
diffraction
(XRD),
photoelectron
(XPS),
field
emission
scanning
electron
microscopy
(FESEM),
transmission
(FETEM),
dynamic
light
scattering
(DLS),
thermal
gravimetric
(TGA),
vibrating
sample
magnetometer
(VSM).
(40
mg)
introduced
as
TBHP
(4
eq)
varied
C–H
bonds
to
related
carbonyl
high
yields.
(5
used
synthesis
benzoxazole
derivatives
from
1
mmol
every
substrate
aldehydes,
ammonium
acetate,
catechol.
By
this
process,
vast
amounts
benzoxazoles
were
satisfyingly
obtained
H
under
moderated
situations,
whole
products
gained
with
excellent
results.
recovered
reaction
environment
through
simple
exterior
magnet
reused
three
times
without
any
remarkable
reactivity
loss.
Moreover,
hot
filtration
test
confirmed
heterogeneous
character
catalyst.
ChemistrySelect,
Journal Year:
2021,
Volume and Issue:
6(4), P. 746 - 753
Published: Jan. 26, 2021
Abstract
In
this
work,
catalytic
activity
of
a
series
copper(I)
complexes
containing
dihydrobis(2‐mercapto‐benzimidazolyl)
borate
(Bb),
and
phosphine
co‐ligands
was
investigated
in
the
synthesis
N
‐heterocycle
compounds
including
2
H
‐indazoles
5‐substituted
1
‐tetrazoles.
The
complex
tricyclohexylphosphine
co‐ligand,
[Cu(Bb)(PCy
3
)],
displayed
highest
activities
for
formation
Apart
from
nontoxicity
strong
σ‐donating
ability
introduced
ligands,
catalyst
required
easy
handling
processes.
reactions
were
successfully
performed
at
low
loadings
either
PEG‐200
or
DMF
relatively
short
reaction
times.
diversity
these
also
explored
with
20
12
examples.
Finally,
current
system
is
amenable
to
large‐scale
production
compounds.
New Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
45(20), P. 8910 - 8917
Published: Jan. 1, 2021
A
series
of
heteroleptic
Cu(i)
complexes
were
precisely
synthesized
using
different
bipyridine
and
diphosphine
ligands.
These
exhibited
fluorescence
sensing
towards
silver
ions
high
catalytic
activity
the
CuAAC
reaction.
Applied Organometallic Chemistry,
Journal Year:
2021,
Volume and Issue:
35(9)
Published: June 22, 2021
2‐(5‐Substituted
phenyl)furan‐2‐carboxaldehyde
derivatives
were
prepared
by
using
an
efficient
copper(II)
complex
of
tetradentate
Schiff‐base
ligand
immobilized
onto
silica
as
a
heterogeneous
nanocatalyst
[Cu(II)
Schiff‐base@SiO
2
]
(5.0
mol%)
anilines,
sodium
nitrite,
and
furan‐2‐carboxaldehyde.
Furthermore,
attractive
di‐heteroaryl
benzo‐fused
systems
such
benzimidazole
benzothiazole
synthesized
this
via
the
reaction
o
‐phenylenediamines
2‐aminothiophenol
with
2‐(5‐substituted
phenyl)furan‐2‐carboxaldehydes
in
EtOH.
The
catalyst
was
characterized
Fourier
transform
infrared
(FT‐IR),
field
emission
scanning
electron
microscope
(FESEM),
energy‐dispersive
X‐ray
spectroscopy
(EDX),
powder
diffraction
(XRD),
inductively
coupled
plasma
(ICP)
techniques.
advantages
present
catalytic
system
are
short
times,
mild
conditions,
good
to
excellent
yields,
low
amount
nanocatalyst.
Moreover,
best
our
knowledge,
is
first
time
same
two
steps
including
synthesis
or
derivatives.
In
addition,
recycled
very
well
reused
several
times
without
significant
loss
its
activity.
European Journal of Organic Chemistry,
Journal Year:
2020,
Volume and Issue:
2020(37), P. 5978 - 5984
Published: Sept. 24, 2020
A
facile,
efficient,
and
eco‐friendly
strategy
to
access
benzoxazole
heterocyclic
products
has
been
accomplished
through
oxidation
of
catechols
followed
by
condensation/cyclization/aromatization
sequences.
This
process
is
catalyzed
nanostructured
iron(III)‐porphyrin
complex
form
desired
derivatives
at
room
temperature
under
air
condition.
The
procedure
widely
applicable
diverse
amines,
can
provide
the
in
a
scalable
fashion,
as
well.
One
most
significant
types
oxidizing
agents
nature
iron‐porphyrin
complexes
(0.1
mol‐%),
existing
structure
hemoglobin.
They
have
benefits
such
low
toxicity
high
potential
for
many
substrates.
