A Virtual Exercise Program throughout Pregnancy during the COVID-19 Pandemic Modifies Maternal Weight Gain, Smoking Habits and Birth Weight—Randomized Clinical Trial

Journal of Clinical Medicine, Journal Year: 2022, Volume and Issue: 11(14), P. 4045 - 4045

Published: July 13, 2022

The intrauterine environment is key to health from a short- and long-term perspective. Birth weight an important indicator that may influence the fetal due epigenetics. Considering physical inactivity, in parallel with higher levels of stress, affecting smoking patterns emotional pregnant population, maintaining future generations crucial. A randomized clinical trial (NCT04563065) was conducted. One-hundred ninety-two healthy individuals were assigned intervention (IG) or control (CG) group. Overall, significant differences found between groups when stratified by birth (χ2 (1) = 6.610; p 0.037) low macrosomia more often CG (4% vs. 14% 3% 9%, respectively) admissions neonatal intensive care unit 5.075; 0.024) (20/28.6%) compared IG (9/13.0). Smoking during pregnancy also (12/17.1%) (3/4.4%) (p 0.016). virtual program supervised exercise throughout ongoing pandemic could help maintain adequate weights, modify maternal habits, lower unit.

Language: Английский

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A Systematic Review of Population-Based Studies Assessing Knowledge, Attitudes, Acceptance, and Hesitancy of Pregnant and Breastfeeding Women towards the COVID-19 Vaccine

Vaccines, Journal Year: 2023, Volume and Issue: 11(8), P. 1289 - 1289

Published: July 27, 2023

The anti-SARS-CoV-2 vaccination is recommended for pregnant women due to the high risk of complications. However, pregnancy has been associated with vaccine hesitancy. Our review aims at summarizing existing literature about hesitancy in and lactating women. research was conducted on PubMed/MEDLINE, ExcerptaMedica Database (EMBASE), Scopus, according PRISMA guidelines. Articles regarding COVID-19 vaccine's acceptance and/or refusal by were selected. Only observational, population-based studies included. Joanna Briggs Institute quality assessment tools employed. A total 496 articles retrieved, after selection process, 21 papers included current analysis. All cross-sectional, mostly from Europe North America. sample sizes ranged between 72 25,111 subjects. them subjects, except one that focused breastfeeding only. Vaccine rates 26% 57% among different studies. Fear adverse events lack knowledge shown be main drivers Approximately half (11/21) classified as low quality, remaining (9/21) moderate, only study quality. Primigravidae also more likely accept vaccination. findings confirm significant Information gaps should addressed contain concerns related events.

Language: Английский

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Pregnancy Outcomes in the COVID-19 Era: An Observational Retrospective Study

Archives of Clinical Infectious Diseases, Journal Year: 2025, Volume and Issue: 20(2)

Published: Jan. 18, 2025

Background: There are ongoing controversies regarding pregnancy outcomes during the COVID-19 era. Objectives: This observational study with a retrospective design was conducted to investigate maternal and neonatal impacts of on outcomes. Methods: An carried out using census sampling from February 2020 July 2021. The population included pregnant women who were referred Asalian Hospital in Khorramabad city, western Iran. A total 769 mothers (107 662 without COVID-19) study. Results: most common symptoms reported by infected body pain/myalgia (68, 72.3%), fatigue (57, 60.6%), headache (47, 50%), shivering (46, 48.9%). After adjusting for covariates, risk caesarean section (CS) found be 3.2 times higher (95% confidence interval: 1.90 - 5.50). In contrast, risks newborn hospitalization, prematurity, low APGAR scores, respiratory distress, smaller head circumference among newborns non-COVID-19-infected than those COVID-19-infected (P < 0.05). Conclusions: While it is generally expected that would experience adverse outcomes, this demonstrated infection does not result or newborns, apart rate CS.

Language: Английский

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Vaccines in Pregnancy: An Update on Recommendations From CDC's Advisory Committee on Immunization Practices

Birth Defects Research, Journal Year: 2025, Volume and Issue: 117(2)

Published: Feb. 1, 2025

Vaccinations in pregnancy are an essential part of prenatal care and play a critical role protecting both pregnant persons their infants from certain infectious diseases. In the United States, recommendations for vaccines made through comprehensive review currently available scientific literature, including clinical trials post-marketing surveillance data, by Advisory Committee on Immunization Practices (ACIP). The ACIP is advisory committee to US Centers Disease Control Prevention (CDC), comprised medical public health experts who develop evidence-based guidelines vaccinations, persons. has several work groups that evidence ongoing basis, full-committee meetings held at least three times year. As more data regarding safety efficacy become available, these continue evolve. To recommendations, carefully considers risks exposure agents against potential vaccination. We here current vaccinations use Recommendations divided into four categories: recommended during pregnancy, under circumstances, not or contraindicated without specific recommendations. ensure optimal healthcare providers need be familiar with

Language: Английский

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Complex evaluation of coagulation, fibrinolysis, and inflammatory cytokines in SARS-CoV-2 infected pregnant women: a prospective, case-control study

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 15, 2025

Background Given the physiological hemostasis changes during pregnancy, limited data exists on COVID-19-induced inflammatory response and alterations in pregnant women. Objectives To test a comprehensive set of cytokines pregnancies with/without COVID-19 correlate results with maternal perinatal outcomes. Patients/methods In this observational case-control study, 100 women acute at 24-40 gestational weeks (COVID-19+ group), healthy, age- week-matched, SARS-CoV-2 negative (32 proven recovery COVID-19) were enrolled. All outpatients mild/no symptoms admission. Detailed (fibrinogen, FVIII, FXIII, VWF, plasminogen, α2-plasmin inhibitor, PAI-1, thrombin generation, clot lysis, D-dimer) cytokine/chemokine panels performed. Clinical parameters labor postpartum period registered. Results COVID-19+ exhibited significantly lower higher VWF levels, decreased peak enhanced lysis vs. controls. Despite symptoms, elevated cytokine including IL-6, INF-γ, MCP-1, IL-18 observed pregnancies, associated distinct alterations. Admission IL-1β, IL-33 lower, while was cases when became more severe, along FXIII plasminogen. group, hemorrhage (PPH) developed 4 cases, reduced increased IL-8, IL-17A, IL-23 levels. Conclusion third trimester mild/asymptomatic marked changes, fibrinolysis found. A potential link between inflammation PPH context warrants further research.

Language: Английский

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SARS-CoV-2, the human placenta, and adverse perinatal outcomes

American Journal Of Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

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Global, regional, national burden of chronic kidney disease attributable to chronic glomerulonephritis in women of child-bearing age from 1990 to 2021 and forecast to 2049: a study from Global Burden of Disease Study 2021

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Background Glomerulonephritis (GN) is a leading cause of chronic kidney disease (CKD), disproportionately affecting women childbearing age (WCBA). Despite the vulnerability this population, global data on CKD attributable to GN in WCBA remain scarce. This study aims address gap by analyzing burden from 1990 2021 and projecting trends through 2049 different groups, regions coutries/territories. Methods Data were sourced Global Burden Disease Study (GBD 2021), focusing incidence disability-adjusted life years (DALYs) for WCBA. Age-standardized rates (ASIR/ASDR) calculated using direct standardization. Trends assessed with Joinpoint regression, while Bayesian age-period-cohort (BAPC) model was employed forecast future burdens. Regions categorized based Socio-Demographic Index (SDI) levels (low, low-middle, middle, high-middle, high). Health inequalities evaluated slope concentration indices, frontier analysis identified countries requiring priority interventions. Results Globally, increased 2021, ASIR peaking 45–49 group, DALYs reaching their highest same group.The occurs 15–19 group. At time, health persist, lower burdens high upper-middle SDI compared those middle low-middle regions. Geographically, lightest are Western Europe high-income Central Asia, heaviest America Asia-Pacific region. In terms growth rates, there has been rapid increase over past three years. Projections indicate that will continue rise until 2049. Conclusions highlights increasing among WCBA, particularly medium low SDI. Strengthening regional collaboration essential, as introduction more diagnostic therapeutic technologies low-SDI areas alleviate burden. Additionally, attention should be given younger older groups within who experience higher Finally, recent years, call vulnerable such stronger focus research into diseases population.

Language: Английский

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An Update on COVID-19 Vaccination and Pregnancy

Journal of Personalized Medicine, Journal Year: 2023, Volume and Issue: 13(5), P. 797 - 797

Published: May 6, 2023

Pregnant women are more prone to experience severe COVID-19 disease, including intensive care unit (ICU) admission, use of invasive ventilation, extracorporeal membrane oxygenation (ECMO), and mortality compared non-pregnant individuals. Additionally, research suggests that SARS-CoV-2 infection during pregnancy is linked adverse outcomes, such as preterm birth, preeclampsia, stillbirth, well neonatal hospitalization admission the unit. This review assessed available literature from November 2021 19 March 2023, concerning safety effectiveness vaccination pregnancy. administered not significant events related vaccine or negative obstetric, fetal, outcomes. Moreover, has same in preventing disease pregnant individuals general population. safest most effective method for protect themselves their newborns hospitalization, ICU admission. Thus, should be recommended patients. While immunogenicity appears similar population, needed determine optimal timing benefit neonate.

Language: Английский

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Fetal brain vulnerability to SARS-CoV-2 infection

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 112, P. 188 - 205

Published: June 16, 2023

Whether or not SARS-CoV-2 can cross from mother to fetus during a prenatal infection has been controversial; however, recent evidence such as viral RNA detection in umbilical cord blood and amniotic fluid, well the discovery of additional entry receptors fetal tissues suggests potential for transmission fetus. Furthermore, neonates exposed maternal COVID-19 later development have displayed neurodevelopmental motor skill deficiencies, suggesting consequential neurological inflammation utero. Thus, we investigated consequences on developing brain using human ACE2 knock-in mice. In this model, found that tissues, including brain, occurred at developmental stages, primarily targeted male fetuses. largely within vasculature, but also other cells neurons, glia, choroid plexus cells; replication increased cell death were observed tissues. Interestingly, early gross differences between infected mock-infected offspring, high levels gliosis seen brains 7 days post initial despite clearance time point. pregnant mice, more severe infections, with greater weight loss dissemination compared non-pregnant Surprisingly, did observe an increase antiviral IFN response these showing clinical signs disease. Overall, findings concerning implications regarding neurodevelopment pregnancy complications following exposure.

Language: Английский

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Retrospective Analysis of the Impact of SARS‐CoV‐2 (COVID‐19) on Pregnancy and Neonatal Outcomes

Journal of Pregnancy, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

The novel coronavirus disease 2019 (COVID-19) was more devastating in people with comorbidities such as advanced age and immunodeficiency. Another group affected by COVID-19 pregnant women. Immunological changes during pregnancy conditions gestational diabetes pre-eclampsia that occur also have effects on the fetus. aim of this study to analyze PCR-proven infection fetus newborn.

Language: Английский

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