The Impact of Oral Microbiome Dysbiosis on the Aetiology, Pathogenesis, and Development of Oral Cancer

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 2997 - 2997

Published: Aug. 28, 2024

Oral squamous cell carcinoma (OSCC) is the most common head and neck cancer. Although oral cavity an easily accessible area for visual examination, OSCC more often detected at advanced stage. The global prevalence of around 6%, with increasing trends posing a significant health problem due to increase in morbidity mortality. microbiome has been target numerous studies, findings highlighting role dysbiosis developing OSCC. Dysbiosis can significantly pathobionts (bacteria, viruses, fungi, parasites) that trigger inflammation through their virulence pathogenicity factors. In contrast, chronic bacterial contributes development Pathobionts also have other effects, such as impact on immune system, which alter responses contribute pro-inflammatory environment. Poor hygiene carbohydrate-rich foods risk factors mechanisms are not yet fully understood remain frequent research topic. For this reason, narrative review concentrates issue potential cause OSCC, well underlying involved.

Language: Английский

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Novel Quaternary Ammonium Urethane-Dimethacrylates for Copolymers with Low Water Sorption and Solubility

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 769 - 769

Published: Feb. 7, 2025

Six novel urethane-dimethacrylates with quaternary ammonium groups (QAUDMAs) were successfully synthesized from 2-(methacryloyloxy)ethyl-2-hydroxyethylmethylalkylammonium bromide (QAHAMA-n, where n was 8 and 10) diisocyanate (isophorone (IPDI), 4,4'-methylenedicyclohexyl (CHMDI), 4,4'-diphenylmethane (MDI)). Their chemical structures confirmed through nuclear magnetic resonance spectroscopy (NMR) Fourier transform infrared (FTIR). The refractive index (RI) density (dm) also determined. QAUDMAs compounded common dental dimethacrylates subsequently photopolymerized. resulting copolymers, comprising QAUDMA 40 wt.%, bisphenol A glycerolate dimethacrylate (Bis-GMA) triethylene glycol (TEGDMA) 20 tested for water sorption (WS) solubility (SL). WS SL values decreased following these orderings based on the diisocyanate: IPDI > CHMDI MDI WS, SL. ranged 11.50 to 13.82 µg/mm3, significantly lower than recommended maximum materials, µg/mm3. that met maximum, 7.5 2.67 6.75 Only copolymer having QAHAMA-8- MDI-derived had slightly exceeding at 7.89

Language: Английский

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Comparative in vitro study of a new silicone mouth swab for soft tissue cleaning under wet and dry brushing conditions

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 9, 2025

The use of silicone mouth swabs for soft tissue cleaning in elderly care is significant as it offers a gentle yet effective solution maintaining oral hygiene, particularly patients with limited dexterity or cognitive impairments, thereby reducing the risk infections and improving overall health. This study aimed to compare pseudo-plaque efficiency newly designed swab that existing MouthEze (MC3) under both wet dry brushing conditions. A new was straight threaded bristles longer head length 24.0 mm, compared MC3, which has only an 18.0 mm head. pseudo-plaque, created by mixing 6.0 g Thicken Up Clear food additive 12.0 ml water coloring, spread onto NISSIN dentoform rubber sheet thickness 2.0 mm. MC3 (n = 12) were attached V.P.2000 tooth machine, operating at 75 rounds per minute force 2.45 N, each used brush surface 25 times ImageJ program analyze quantify area where removed after brushing. two-way analysis variance (ANOVA) conducted assess differences removal between groups. significantly higher than (72.30 ± 10.21 mm2 vs. 53.69 5.66 mm2, p < 0.05) conditions (66.82 11.29 mm² 53.33 8.54 0.05). more shorter

Language: Английский

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Effect of the Darolac® (Oralis SB®) Probiotic Formulation on Oral Health: A Narrative Review

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 408 - 408

Published: Feb. 13, 2025

Gingivitis and periodontitis are prevalent periodontal conditions associated with dysbiosis of the oral cavity, which leads to inflammation bleeding gums, loss tooth attachment, degradation underlying bone structure. The standard adjunctive treatment for conditions, chlorhexidine mouthwash, is effective but several side effects. Probiotics have been explored as an alternative solution that promotes health by restoring homeostasis in cavity. This review presents a summary clinical trials using Darolac® (Oralis SB®) probiotic formulation (Lactobacillus acidophilus Rosell®-52, Lactobacillus rhamnosus Rosell®-11, Bifidobacterium longum Rosell®-175 Saccharomyces boulardii CNCM I-1079) mouthwash support maintenance or restoration its balance. In reviewed studies, compared placebo other common solutions including mouthwash. Studies show even superior available solutions, supports use adjuvant health. effects on reduction pathogens markers reviewed, association between periodontitis, inflammation, systemic diseases, well their implications probiotics field, discussed.

Language: Английский

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Cameroonian medicinal plants used in the management of oral diseases: An updated review

Advances in Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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FORMULATION AND IN VITRO EVALUATION OF ANTIBACTERIAL POTENTIAL OF PINEAPPLE (ANANAS COMOSUS (L) MERR) PEELS EXTRACT MOUTHWASH

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 89 - 93

Published: Feb. 24, 2025

Objective: Pineapple peel is a byproduct of pineapple commonly found in Indonesia. Its abundant metabolites are promising as natural antibacterial agent and developed mouth care product. This research aimed to formulate mouthwash product using extract, evaluate the formula according internationally accepted regulation standards, investigate its activity. Methods: The extract obtained by ethanol maceration process then went through filtration evaporation. was incorporated into co-solvation techniques evaluated for physicochemical properties activity towards Streptococcus mutans, Porphyromonas gingivalis, Lactobacillus acidophilus. Results: formulation met standard criteria these parameters: microbial test, metal impurities, alcohol content. also shows S. P. L. acidophilus with zones inhibition were 10.17± 1.25 mm, 11.75±0.54 7.25±0.54 respectively. Conclusion: microbiological evaluation confirmed formula's compliance Indonesian Food Drug Regulatory Body toward aureus,

Language: Английский

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Innovative strategies targeting oral microbial dysbiosis: unraveling mechanisms and advancing therapies for periodontitis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 30, 2025

Periodontitis, a prevalent inflammatory oral disease, is intricately linked to disruptions in the microbiome, state known as microbial dysbiosis. This review explores pivotal roles of key pathogens, including Porphyromonas gingivalis and Tannerella forsythia , driving periodontitis examines underlying molecular mechanisms that disrupt homeostasis. We discuss how interactions among bacterial species affect ecosystem’s balance metabolites influence host immune responses, contributing disease progression. Leveraging these insights, we propose cutting-edge therapeutic approaches aimed at restoring equilibrium. These include personalized pharmacological interventions tailored individual microbiome profiles innovative microbiome-targeted strategies such probiotic formulations bacteriophage therapy. By precisely modulating communities, hold promise for enhancing treatment efficacy, preventing recurrence, mitigating issues like antimicrobial resistance. Overall, this paves way novel prevention management techniques periodontitis, offering significant improvements health outcomes patients.

Language: Английский

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Antiplaque and Antigingivitis Effects of a Novel Oral Care Regimen Featuring Stannous Fluoride Toothpaste, a Unique Toothbrush, and Cetylpyridinium Chloride Mouthwash: A Randomized Clinical Trial

Journal of Evidence Based Dental Practice, Journal Year: 2025, Volume and Issue: 25(2), P. 102123 - 102123

Published: Feb. 12, 2025

Antibacterial ingredients for oral care products are typically measured through single product forms. This study assessed the overall health outcome of using multiple forms: a stabilized stannous fluoride toothpaste, an enhanced cetylpyridinium chloride mouthwash and unique toothbrush to deliver antibacterial performance. A 12-week, single-center, phase III, masked, 2-arm, parallel-group, randomized controlled trial was conducted assess reduction established dental plaque gingivitis with novel regimen comprised 0.454% toothpaste nitrate phosphates, 0.075% 0.28% zinc lactate mouthwash, rapid foaming manual compared nonantibacterial commercially available containing 0.76% sodium monofluorophosphate, no represent standard toothbrushing practices. Adherence this provided significant in control starting at 1 week (P < .01) continuing over 12 weeks .001) across all gingival score indices. At 1, participants Regimen Group showed 15 times more than .001). After 3 adherence, 100% had improved index scores baseline. Within limitations study, results statistically significantly reduced inflammation from adherence

Language: Английский

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Clinical Efficacy and Patient-Reported Outcomes of Coconut Oil as Adjunctive Periodontitis Treatment: Triple-Blinded Randomized Trial

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Background: To evaluate the clinical outcomes of periodontal patients treated with nonsurgical therapy or without coconut oil as an adjunctive method. Methods: Thirty participants stage II-III periodontitis were randomly assigned to three groups: oil, 0.12% chlorhexidine, and placebo (coconut-flavored water) for one month, followed by therapy. A blinded examiner assessed plaque index, bleeding on probing, probing pocket depth, attachment level, saliva pH, tooth color, sulfur compounds in breath, patient-reported outcomes, including Oral Health Impact Profile-14. Results: Compared placebo, both chlorhexidine significantly reduced index (p=0.001; p=0.006), p=0.001), depth level p=0.015) (p=0.045; p=0.003). Compared was more effective at decreasing loss (p=0.006). Chlorhexidine associated increased burning sensation (p=0.03) color changes (p<0.001), whereas degree mouth dryness perception (p<0.001). Coconut improved breath (p=0.003; p=0.030). Patients preferred over (p=0.006; p=0.015). The quality life group (p=0.024). Conclusions: enhance health. However, reduces improves adverse effects chlorhexidine. Nonetheless, indicating that taste mouthfeel are important compliance.

Language: Английский

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A Low-Cost Protocol Using the Adjunctive Action of Povidone–Iodine Irrigations and Sodium Hypochlorite Rinsing Solution in Step 2 of Periodontal Therapy for Patients with Stage III–IV Periodontitis: A Single-Blind, Randomized Controlled Trial

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(5), P. 144 - 144

Published: May 15, 2024

In severe stages of periodontitis, conventional periodontal therapy and maintenance care are usually insufficient due to the viral bacterial etiology; thus, a mechanical approach alone may not be sufficient eliminate substantial portion subgingival pathogens, especially in deep sites. Background Objectives: This single-blind, randomized clinical trial aimed compare microbiological efficacy low-cost protocol using povidone–iodine sodium hypochlorite formulations as adjuncts non-surgical for patients with stage IV periodontitis when compared chlorhexidine, most commonly employed substance date antimicrobial regimens therapy. Materials Methods: Forty-five were randomly divided into two groups: control (subgingival instrumentation, chlorhexidine-assisted) test (antiviral medication, instrumentation povidone–iodine, rinsing solution, antibiotics). Clinical measurements analyses performed at baseline after three months. Results: After months, notable differences found detection scores Porphyromonas gingivalis (a significant reduction frequency was observed (p = 0.021)), there reductions group Tannerella forsythia Treponema denticola, showing undetectable levels < 0.0001 both). group, pocket probing depth median value reduced significantly 0.0005); similarly, bleeding on showed marked decrease 0.0001). However, changes attachment loss full-mouth plaque score statistically significant. Conclusions: Using proposed protocol, improvements parameters obtained current recommendations.

Language: Английский

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