Salud Ciencia y Tecnología,
Journal Year:
2024,
Volume and Issue:
4
Published: Jan. 1, 2024
Cancer
is
a
major
global
public
health
problem,
with
increasing
incidence.
When
detected
early,
life-saving
treatments
can
be
applied.
Radiotherapy
eliminates
malignant
cells
but
damages
healthy
tissues.
A
common
oral
side
effect
mucositis:
inflammation,
ulcers,
pain,
difficulty
ingesting
nutrients,
treatment
interruption.
Propolis,
natural
product
from
bees,
has
wound
healing,
anti-inflammatory,
antibiotic,
and
antioxidant
properties.
Studies
indicate
its
effectiveness
against
radiation-induced
mucositis.
The
objective
of
the
present
work
was
to
analyze
propolis
in
mucositis
patients
undergoing
radiotherapy,
based
on
critical
review
clinical
studies.
literature
study
conducted
scientific
articles
found
databases
such
as
PubMed,
Web
Science,
Scopus,
order
obtain
information
support
use
complement
conventional
radiotherapy.
Numerous
studies
have
demonstrated
treating
mucositis,
especially
when
applied
directly
mucosa.
Additionally,
been
proven
safe
does
not
cause
adverse
effects
patients.
It
evident
that
which
occur
first
week
treatment,
causing
swallowing,
even
interruption
cancer
treatment.
Propolis
represents
promising
therapeutic
option
improve
delay
onset
this
condition,
enhancing
quality
life
BDJ Open,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 25, 2025
Abstract
Background
and
objectives
Gingivitis
periodontitis
are
common
periodontal
diseases
that
can
significantly
harm
overall
oral
health,
affecting
the
teeth
their
supporting
tissues,
along
with
surrounding
anatomical
structures,
if
left
untreated,
leading
to
total
destruction
of
alveolar
bone
connective
tooth
loss,
other
more
serious
systemic
health
issues.
Numerous
studies
have
shown
propolis
help
reduce
gum
inflammation,
inhibit
growth
pathogenic
bacteria,
promote
tissue
regeneration,
but
varying
degrees
success
reported.
For
this
reason,
comprehensive
systematic
review
aims
at
finding
out
truth
concerning
efficacy
mouthwashes
in
treating
gingivitis
periodontitis,
as
its
main
objective.
Data
sources
Research
findings
from
6
different
databases:
China
National
Knowledge
Infrastructure
(CNKI),
PubMed®,
Europe
PMC,
Cochrane
Central
Register
Controlled
Trials
(CENTRAL),
BioMed
Central,
Google
Scholar,
were
retrieved
examined
addition
a
manual
search
references
lists.
Study
selection
synthesis
The
PICOS
framework
was
used
select
exclude
studies.
focus
on
clinical
randomized
controlled
trials
(RCTs)
effectiveness
propolis-containing
comparison
propolis-free
ones
for
treatment
employing
related
indices.
Animal
studies,
microbiological
in-vitro
retrospective
case-control
cohorts,
case
reports,
series,
reviews,
letters,
editorials,
meta-analyses,
non-clinical
(non-RCTs),
all
excluded.
A
meta-analysis
not
performed
data
only
studied
qualitatively
due
obvious
heterogeneity
amongst
selected
extracted,
then
revised
Cochrane’s
risk
bias
tool
(RoB
2.0)
utilised
by
two
authors,
independently,
evaluate
each
study.
Results
At
first,
151
results
reached,
after
removing
duplicates,
99
records
remained,
later
screened,
assessed,
full
details
based
set
criteria.
Out
these
articles,
ten
included
review,
encompassing
453
patients
an
age
range
(13–70)
years
old.
Propolis
protocols
application
intervention
whereas
placebo
or
rest
tested
such
as,
chlorhexidine,
sodium
fluoride
cetylpyridinium
chloride,
sterile
distilled
water,
hydrogen
peroxide,
which
compared.
Treatment
duration
extended
14
days
3
months
follow-up
period
differed
months.
In
general,
decreased
plaque
accumulations
gingival
inflammation
employed
On
hand,
aforementioned
than
deemed
equally
effective
even
superior
some
As
assessment
bias,
four
assigned
having
low
bias.
Two
concerns,
while
identified
high
Conclusions
Despite
fact
has
positive
effects
terms
controlling
especially
when
mechanical
methods,
lack
certainty
power
evidence
is
no
agreed
gold
standards.
These
conclusions
come,
sure,
within
limitations
like
substantial
variability
presence
demonstrate
propolis-based
showed
promising
outcomes
reducing
inflammation.
However,
it
highly
recommended
conduct
rigorous
patient-reported
outcome
measures,
periods,
larger
samples
sizes,
better-designed
methodologies,
typified
use,
implementation
similar
indices
order
obtain
reliable,
conclusive,
generalisable
results.
Prospero
Registration
Number
CRD42024524523.
Aim:
To
evaluate
the
efficacy
of
experimental
propolis
varnish
containing
15%
green
in
reducing
Streptococcus
mutans
(SM)
from
saliva
and
dental
biofilms.
Methods:
Patients
aged
8–11
years
were
recruited
a
preventive
program.
After
prophylaxis,
was
applied
to
collect
biofilm
samples
at
regular
times
(baseline/T0,
2nd
day/T1,
3rd
day/T2,
4th
day/T3,
5th
day/T4,
10th
day/T5,
15th
day/T6,
30th
day/T7).
each
sampling,
stimulated
whole
homogenized
for
30
s,
tenfold
serial
dilutions
saline
plated
on
mitis-salivarius-bacitracin
(MSB)
agar
incubated
37°C
48
h.
Colonies
with
typical
morphology
counted,
number
colony-forming
units
(CFU)/mL
compared
via
an
independent
sample
t
test.
For
quantitative
real-time
PCR
(qPCR),
data
statistically
analysed
one-way
ANOVA
Holm‒Sidak
post
hoc
Results:
There
significant
difference
salivary
SM
levels
between
T0/T1
(baseline/2nd
day)
T1/T7
(2nd
day/30th
day),
but
no
observed
day
onwards.
The
qPCR
results
also
revealed
decrease
SMs
first
days
after
application.
Conclusions:
A
single
application
reduced
biofilms
three
days.
Whether
these
findings
affect
incidence
caries
needs
be
confirmed
through
studies,
which
may
improve
original
formulation
(International
Clinical
Trials
Registry
Platform
registration
code:
NCT02052973).
Cureus,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 14, 2025
Endodontic
treatment
of
permanent
teeth
(immature
and
mature)
with
propolis
in
healthy
patients
remains
uncertain,
conflicting
evidence.
Therefore,
this
systematic
review
aims
to
evaluate
the
current
literature
on
safety
efficacy
endodontic
procedures.
An
extensive
search
was
performed
using
PubMed,
Scopus,
Web
Sciences,
Google
Scholar.
Only
human
randomized
clinical
trials
(RCTs)
that
explored
applications
endodontics
were
considered.
Narrative
synthesis
performed,
risk
bias
(RoB)
for
methodological
quality
assessment
Cochrane
RoB-2
via
Robvis
web-based
application.
Eight
RCTs
selected,
focusing
vital
pulps
direct
pulp
capping
non-vital
root
canal
disinfection
filling
materials.
Propolis
demonstrated
promising
effects,
including
controlling
inflammation,
promoting
tissue
healing,
disinfecting
system.
However,
no
significant
differences
observed
when
comparing
other
materials
used
or
intracanal
medicaments.
The
RoB
revealed
varied
levels
risk,
two
studies
exhibiting
a
high
three
having
unclear
risks,
showing
low
risk.
Moderate
certainty
evidence
observed.
Based
evidence,
there
is
insufficient
data
recommend
over
teeth.
not
recommended
as
definitive
due
limited
variability
outcomes
across
studies.
future
high-quality
are
essential
more
conclusions.
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(3), P. 1164 - 1164
Published: Jan. 24, 2025
Chronic
kidney
disease
(CKD)
is
an
extremely
widespread
pathology
characterized
by
numerous
metabolic
alterations,
including
impairments
of
calcium–phosphorus
and
vitamin
D
metabolisms,
which
lead
to
a
condition
known
as
CKD–mineral
bone
disorders
(CKD-MBDs).
In
CKD
children,
this
pathological
induces
anomalies
in
physiological
growth
processes,
alterations
morphology,
renal
osteodystrophy
rickets.
CKD-MBDs
are
not
only
associated
with
systemic
complications
but
also
show
dental
maxillofacial
manifestations
children.
fact,
children
affected
present
defects
enamel
development
when
compared
healthy
Therefore,
the
aims
narrative
review
focus
on
hard
tissues
investigate
possible
correlation
between
presence
developmental
enamel.
addition,
risk
protective
factors
caries
pediatric
patients
analyzed.
The
describes,
multidisciplinary
nephrological–dental
approach,
pathogenic
mechanisms
that
can
cause
structure
patients.
The Saudi Dental Journal,
Journal Year:
2025,
Volume and Issue:
37(4-6)
Published: May 10, 2025
This
study
compared
the
efficacy
of
nanopropolis
and
nanocurcumin
as
direct
pulp-capping
agents
to
that
mineral
trioxide
aggregate
(MTA)
in
recently
erupted
permanent
molars,
assessing
clinical
radiographic
outcomes
over
six
months.
Thirty
molars
were
randomly
allocated
three
groups
(n
=
12
each):
MTA
(control),
nanocurcumin.
The
followed
a
double-blind
design.
Clinical
radiological
evaluations
assessed
pain,
percussion
sensitivity
swelling
preoperatively
one
week,
months
afterwards.
At
group
showed
significantly
higher
pain
levels
than
groups.
scores
equalised
by
remained
stable
until
all
Percussion
occurred
8.3%
cases
group,
25%
16.7%
group.
Nanopropolis
provided
comparable
pulp
capping
molars.
While
slightly
superior
attributes,
natural
nanomaterials
present
viable
alternatives.
supports
potential
use
bioactive
derived
from
sources
vital
therapy,
though
longer-term
investigations
are
warranted.
Life,
Journal Year:
2025,
Volume and Issue:
15(5), P. 764 - 764
Published: May 9, 2025
Honeybee
(Apis
spp.)
products
have
been
used
for
centuries
due
to
their
nutritional
value
and
diverse
healing
properties.
Propolis,
produced
by
honeybees,
is
a
unique
resin
collected
from
tree
buds,
sap
flows,
other
plant
exudates,
which
then
mixed
with
bee
enzymes,
beewax,
secretions.
This
comprehensive
review
starts
meta-analysis
following
the
PRISMA
approach
explore
recent
advances
in
chemical
composition
of
propolis,
its
biological
activities
pharmacological
properties,
applications
products,
future
perspectives.
The
propolis
varies
depending
on
source,
season
harvest,
geography,
type
flora,
climate,
honeybee
species
at
site
collection,
some
these
are
related.
Flavonoids,
aromatic
acids,
phenolic
esters
key
bioactive
compounds
contributing
such
as
antioxidant,
antibacterial,
antiparasitic,
antiviral,
antileishmanial,
antidiabetic,
anti-inflammatory,
immunomodulatory,
anticancer
effects.
In
summary,
stands
out
multifaceted
natural
product
broad
spectrum
activities.
aims
provide
valuable
insights
researchers,
practitioners,
decision-makers
involved
studying
sources,
composition,
propolis.
highlighted
hotspots
emerging
frontiers
presented
herein
poised
unlock
full
potential
paving
way
innovative
health
wellness.
