Impaired Oral Health-Related Quality of Life in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review DOI Creative Commons

Nishath Sayed Abdul,

Sahana Shivakumar,

Nitin V Muralidhar

et al.

Journal of Evidence Based Dental Practice, Journal Year: 2024, Volume and Issue: 25(1), P. 102055 - 102055

Published: Nov. 20, 2024

Chronic obstructive pulmonary disease (COPD) has been associated with various health implications, including potential effects on oral and Oral Health-Related Quality of Life (OHRQoL). Understanding the relationship between COPD dental is crucial for optimizing patient care well-being. This review aims to assess existing literature impact OHRQoL. The process followed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in databases, resulting 304 records. Data extraction done by 2 reviewers separately. variables included study ID, sample, age, gender ratio, type study, respiratory evaluation, OHRQoL assessment, inferences. Newcastle Ottawa scale employed methodological quality studies. final selection 3 studies eligible qualitative synthesis. OHIP-5 OHIP-14 were used These provided valuable insights into association health. negatively impacted among sufferers. In addition, patients demonstrated significantly fewer teeth higher plaque index (PI) as compared control cohorts. risk bias low But available scarce, which warrants further longitudinal a larger sample size this regard. evidence from selected suggests significant parameters, well their Dental assessments should be integrated management better understand severity exacerbation risk. An interdisciplinary approach involving both professionals care. Future research explore underlying mechanisms conduct establish causal relationships. findings contribute our understanding complex interplay have implications improving outcomes life.

Language: Английский

Structure-Based In Silico Drug Design and Docking Studies of Plant Phytochemicals as Fibroblast Growth Factor Receptor Inhibitors in Oral Squamous Cell Carcinoma DOI Creative Commons

B. Dharshini,

Arul Prakash Francis, Gayathri Rengasamy

et al.

Journal of Indian Academy of Oral Medicine and Radiology, Journal Year: 2025, Volume and Issue: 37(1), P. 71 - 77

Published: Jan. 1, 2025

Background: Oral squamous cell carcinoma (OSCC) accounts for 90% of all head and neck cancer the fibroblast growth factor receptors (FGFR) was recognized as a therapeutic target in OSCC. Objectives: In this study, bioactive compounds from Chimaphila umbellata were screened their potential interaction towards FGFR with help bioinformatics tools. Methods: Drug-likeness pharmacokinetics properties phytochemicals analyzed using online web server Swiss ADME. Expression profiling protein-protein (PPI) analyses conducted GEPIA String. Docking carried out Autodock Tools 1.5.7 Toxicity predicted ProTox II. The biological activity spectrum (BAS) PASS server. Results: About 15 selected C. which, 13 showed drug-likenesses pharmacokinetics. FGFR4 demonstrated connections other genes PPI network. Among compounds, 4 best affinity FGFR. Finally two namely arbutin kaempferol possess oral bioavailability no toxicity. BAS prediction antineoplastic leads. Conclusion: Two leads identified inhibitor through silico . These should be tested vitro vivo studies to confirm action

Language: Английский

Citations

0
Impaired Oral Health-Related Quality of Life in Individuals with Chronic Obstructive Pulmonary Disease: A Systematic Review DOI Creative Commons

Nishath Sayed Abdul,

Sahana Shivakumar,

Nitin V Muralidhar

et al.

Journal of Evidence Based Dental Practice, Journal Year: 2024, Volume and Issue: 25(1), P. 102055 - 102055

Published: Nov. 20, 2024

Chronic obstructive pulmonary disease (COPD) has been associated with various health implications, including potential effects on oral and Oral Health-Related Quality of Life (OHRQoL). Understanding the relationship between COPD dental is crucial for optimizing patient care well-being. This review aims to assess existing literature impact OHRQoL. The process followed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) guidelines. A comprehensive search was conducted in databases, resulting 304 records. Data extraction done by 2 reviewers separately. variables included study ID, sample, age, gender ratio, type study, respiratory evaluation, OHRQoL assessment, inferences. Newcastle Ottawa scale employed methodological quality studies. final selection 3 studies eligible qualitative synthesis. OHIP-5 OHIP-14 were used These provided valuable insights into association health. negatively impacted among sufferers. In addition, patients demonstrated significantly fewer teeth higher plaque index (PI) as compared control cohorts. risk bias low But available scarce, which warrants further longitudinal a larger sample size this regard. evidence from selected suggests significant parameters, well their Dental assessments should be integrated management better understand severity exacerbation risk. An interdisciplinary approach involving both professionals care. Future research explore underlying mechanisms conduct establish causal relationships. findings contribute our understanding complex interplay have implications improving outcomes life.

Language: Английский

Citations

0