Clinical Evaluation, Management, and Control of Dyslipidemia through Unani System of Medicine: A Case Study DOI

Misbahuddin Azhar,

Mustehasan,

Sadia Ayub

et al.

Published: Oct. 1, 2022

Abstract Dyslipidemia ( Dassumat-e-Dam ), a condition characterized by abnormal lipid levels in the blood, is major risk factor for cardiovascular diseases. In Unani medicine, refers to accumulation of harmful substances potentially correlating with modern concepts dyslipidemia. The System Medicine emphasizes holistic approaches, including dietary and lifestyle modifications, along natural remedies restore humoral balance. This case study aims evaluate efficacy management treating patient diagnosed A 45-year-old male presenting elevated total cholesterol, low-density lipoprotein (LDL), triglycerides (TGs), alongside reduced high-density (HDL), . comprehensive regimen was implemented, comprising modifications ‘Ilāj bi’l Ghidhā changes Tadbīr pharmacological interventions using Cap Garcinia (a marketed product) pharmacopoeial preparations ‘Arq Mako Kasni (Distillate Solanum americanum Mill. Chichorium intybus L.), respectively, 90 days. results indicated significant improvement profile were observed, reductions cholesterol (137.47%), LDL (85%), TGs (82.01%), 19.4% increase HDL levels. reported improved overall well-being compliance regimen. No adverse effects noted. success this highlights potential traditional medicine as complementary approach managing offers promising alternative Further clinical studies larger sample sizes are recommended validate these findings explore long-term efficacy.

Language: Английский

Regional variation of risk factors among diabetic retinopathy patients in India: Findings from the INDO EYE study DOI Creative Commons

Gopal S Pillai,

Bibhuti Prassan Sinha,

C S Sheeba

et al.

Journal of Clinical Ophthalmology and Research, Journal Year: 2025, Volume and Issue: 13(1), P. 9 - 13

Published: Jan. 1, 2025

Context: Diabetic retinopathy (DR) is a major cause of vision impairment among diabetics, with significant regional variations in its prevalence and associated risk factors across India. Aims: This study aims to assess the variation for DR, including demographic behavioral characteristics, identify differences severity DR four geographic zones Settings Design: Data were sourced from INDO EYE registry, encompassing six tertiary eye care hospitals The was designed analyze compare DR-related variables different zones: south, central, west, east. Subjects Methods: analyzed data 7112 eyes 3699 patients diagnosed DR. Demographic, clinical, collected, age, gender, substance abuse history, comorbidities, . Statistical Analysis Used: Descriptive statistics summarized clinical characteristics. Chi-square tests assessed associations between categorical variables, one-way ANOVA evaluated continuous zones. significance set at P < 0.05, analysis performed using IBM SPSS Statistics 28. Results: revealed factors. central zone had highest proportion proliferative diabetic macular edema, while south west showed better visual outcomes higher proportions certain comorbidities. east exhibited rates broader range acuity outcomes. Conclusions: Regional disparities highlight need targeted public health strategies address local improve diabetes management Enhanced healthcare access tailored interventions are crucial reducing loss.

Language: Английский

Citations

0
Trends and Prevalence of Severe Hypertriglyceridemia in Pakistan: A Five-Year Analysis (2019-2023) DOI

Quratul Ain,

Madeeha Khan, Amjad Nawaz

et al.

Journal of clinical lipidology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Chronic Statin-Use Before PCI in Acute Coronary Syndromes and In-Hospital Outcomes: ACC-NCDR Registry in India DOI Creative Commons
Rajeev Gupta, Prashant Dwivedi, Krishna Kumar Sharma

et al.

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 100999 - 100999

Published: April 1, 2025

Language: Английский

Citations

0
Exserolide J ameliorates lipid accumulation in vitro by regulating liver X receptor alpha and peroxisome proliferator-activated receptor alpha proteins DOI Creative Commons

Yan Zhang,

Xue Wang, Tian Liu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31861 - e31861

Published: May 23, 2024

Exserolides are isocoumarin derivatives containing lactone moiety. Recently, some isocoumarins have been demonstrated to ameliorate hyperlipidemia, a major factor for inducing cardiovascular diseases. However, the effects and mechanisms of action exserolides on hyperlipidemia not known. The aim this study is investigate whether marine fungus Setosphaeria sp.-derived (compounds I, J, E, F) exert lipid-lowering via improving reverse cholesterol transport (RCT) in vitro. RAW264.7 macrophages HepG2 cells were used establish lipid-laden models, levels intracellular lipids RCT-related proteins determined by assay kits Western blotting, respectively. We observed that (at 5 μM concentration) significantly decreased triglyceride oxidized low-density lipoprotein-laden markedly improved [3H]-cholesterol efflux. Among four tested compounds, exserolide J increased protein ATP-binding cassette transporter A1, peroxisome proliferator-activated receptor α (PPARα), liver X (LXRα). Furthermore, treatment with oleic acid-laden lipid accumulation hepatocytes. Mechanistically, enhance PPARα levels; furthermore, compound increases 7 alpha-hydroxylase A1 LXRα levels. Molecular docking revealed exserolides, particularly can interact proteins. These data suggest terminal carboxyl group plays key role lowering stimulating In conclusion, exhibits powerful its hypolipidemic vivo should be investigated future.

Language: Английский

Citations

3
Relation of Mitochondrial DNA Copy Number and Variants with the Clinical Characteristics of Polycystic Ovary Syndrome DOI

Samia Palat Thariyal,

Sayli Rasal,

Ulka Gawde

et al.

Molecular and Cellular Endocrinology, Journal Year: 2024, Volume and Issue: 594, P. 112386 - 112386

Published: Oct. 18, 2024

Language: Английский

Citations

2
Evaluating Dyslipidemia and Atherogenic Indices as Predictors of Coronary Artery Disease Risk: A Retrospective Cross-Sectional Study DOI Open Access

Joyce S Jose,

Madhu Latha Karra, Aparna Varma Bhongir

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 10, 2024

The frequency of coronary artery disease (CAD) has alarmingly increased in India accounting for the majority all fatalities. primary risk factor CAD, acute myocardial infarction, and stroke is dyslipidemia. CAD can be ascertained by lipid profile as well atherogenic indices. Due to current scenario prevalence established role dyslipidemia a this study aimed at identifying prevalent abnormalities tertiary care hospital Telangana studying predictive value indices assessing risk.

Language: Английский

Citations

1
Indian dyslipidaemia guidelines: Need of the hour DOI Creative Commons
J.P.S. Sawhney, Rajeev Gupta

Indian Heart Journal, Journal Year: 2024, Volume and Issue: 76, P. S2 - S5

Published: Jan. 13, 2024

Language: Английский

Citations

0
Evaluation of lipid profile and hematological parameters among patients attending Ram Janaki Hospital, Janakpurdham DOI Open Access

Manohar Kumar Sah,

Hem Shankar Yadav,

Sandhya Bishwakarma

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 12(02), P. 58 - 66

Published: Aug. 27, 2024

Background & Objectives: Hematological and lipid profiles play crucial roles in assessing healthconditions monitoring physiological abnormalities. serve as valuable tools this context, providing insights into various health conditions. However, due to factors like diet, socioeconomic status, literacy, these can differ significantly across populations. Therefore, we aimed find out the hematological well biochemical parameters among patients attending Ram Janaki Hospital, Janakpurdham.Materials Methods: This hospital based study involved 140 medicineOPD between September 2023 February 2024. Anthropometric measurements, blood pressure,and BMI was calculated. Venous samples were collected. wereassessed using a fully utomated hematology analyzer, while evaluated usingsemi analyzer Erba Chem 7 with ErbaDiagnostics kits. Data analysis performedusing SPSS version 21.Results: The population comprised an equal distribution of males females. Males exhibitedhigher values weight, height, BMI, pressure compared Hematologicalanalysis revealed higher hemoglobin levels, red cell counts, packed volume males,while females showed total leukocyte counts. Lipid profile indicated totalcholesterol LDL levels males, whereas had HDL, triglyceride, VLDLlevels. Conclusion: finding highlights significant gender differences anthropometric,hematological, Janakpurdham. findings emphasizethe importance considering clinical evaluations treatment plans. Theobserved variations from international norms underscore need for specificreference ranges.

Language: Английский

Citations

0
Advances in pharmacotherapy of dyslipidemia DOI

Harshitha Chinta

National Journal of Pharmacology and Therapeutics, Journal Year: 2024, Volume and Issue: 2(2), P. 68 - 71

Published: May 1, 2024

Abstract: Dyslipidaemia is a group of disorders lipoprotein metabolism with consequences endothelial dysfunction, atherosclerosis and increase in thrombogenecity blood. Management dyslipidaemia include diet lifestyle modifications followed by pharmacotherapy. There are multiple drugs used for the management statins as most widely therapeutic class. other class like resins, fibrates, niacin, ezetimibe being established treatment dyslipidaemia. With identification mutations specific genes receptors on observation adverse effects due to modalities available, there need new targets find an alternative treatment. Thus, agents approved microsomal triglyceride transfer protein inhibitors, proprotein convertase substillin/klexin type 9 omega 3 fatty acid ethyl esters, antisense inhibition Apo B-100 synthesis. Although available have well defined actions effects, yet still some patients either they could not fulfil desired lipid lowering goals or intolerant/ non respondent imbalance between risk-benefit profile. developed, described pipeline drugs. Some these cholesteryl ester inhibitor, ATP citrate lyase oligonucleotide inhibitor A C–III, angiopeptin-like-3 AMP kinase activators, cylodextrins, thyroid receptor beta agonists, peroxisome proliferator-activated acetyl CoA carboxylase diacylglycerol transferase coenzyme cholesterol transferase-1 gene therapy active immunisations.

Language: Английский

Citations

0
Evaluation of <i>Lactobacillus acidophilus</i> and <i>Bacillus coagulans</i> against Simvastatin-induced Rhabdomyolysis in Hypercholesterolemic Rats DOI Open Access

Kumar Raja,

A. Shanta Kumari,

A. Prameela Rani

et al.

Journal of Natural Remedies, Journal Year: 2024, Volume and Issue: unknown, P. 1835 - 1848

Published: Aug. 31, 2024

Background: This study investigates the possible synergistic influence of probiotics, specifically Lactobacillus acidophilus (LA) and Bacillus coagulans (BC), in conjunction with Simvastatin (SMV) for treating Rhabdomyolysis hypercholesteremic rats. Aim: The aims to evaluate combined effects SMV LA or BC on various health parameters rats induced rhabdomyolysis. Methods: Hypercholesteremic rhabdomyolysis were treated SMV, LA, BC, combinations BC. measured body weight, lipid profiles, renal function, skeletal muscle, inflammation markers. Results: combination treatments showed promise reducing weight gain. Regarding tandem demonstrated slightly enhanced efficacy regulation compared other combinations. Both probiotic strains exhibited substantial potential preserving nephron function alongside SMV. Probiotic helped mitigate muscle dysfunction. inflammation, both alleviated symptomatic Notably, excelled dampening inflammatory cytokines like TNF-α IL-6, surpassing LA. Conclusion: administration effectively mitigates rhabdomyolysis-induced issues, varying impacts diverse outcomes. Future investigations are imperative comprehensively ascertain optimal regimen managing These positive outcomes underscore multifaceted roles probiotics addressing rhabdomyolysis-related complications, emphasizing necessity further exploration into their mechanisms clinical implications.

Language: Английский

Citations

0