CORONAVIRUS DISEASE 2019 (COVID-19): A LITERATURE REVIEW

Gevher Nesibe Journal IESDR, Journal Year: 2021, Volume and Issue: 6(12), P. 56 - 72

Published: May 25, 2021

In early December 2019, an outbreak of coronavirus 2019 (COVID-19) caused by a novel severe acute respiratory syndrome 2 (SARS-CoV-2) occurred in Wuhan, China's Hubei province. On 30 January 2020, the World Health Organization and International Public declared emergency, as 23.03.2021, laboratory-approved 123,097,155 cases 2,716,151 deaths were reported worldwide. The perceived risk disease has led many countries to adopt various control measures. Emerging genetic clinical evidence suggests pathway similar SARS MERS. Potential therapeutic strategies that are currently being evaluated derive mainly from previous experience with Covid-19 treatment. Although several potential treatments for COVID-19 MERS have been identified animal vitro models, human trials still lacking, which hinders progress This review requires overview three major deadly coronaviruses assessment factors applicable lessons stop their spread leveraging learned first two outbreaks identifying areas improvement future preparedness plans. persistence can help inform public health officials medical practitioners efforts combat its progress. Also, this review, pathogenesis, epidemiology, diagnosis, treatment, vaccine reviewed.

Language: Английский

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Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia (Giloy) and Ocimum sanctum (Tulsi) – a molecular docking study

Journal of Biomolecular Structure and Dynamics, Journal Year: 2020, Volume and Issue: 40(1), P. 190 - 203

Published: Aug. 27, 2020

COVID-19 (Coronavirus disease 2019) is a transmissible initiated and propagated through new virus strain SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) since 31st December 2019 in Wuhan city of China the infection has outspread globally influencing millions people. Here, an attempt was made to recognize natural phytochemicals from medicinal plants, order reutilize them against by virtue molecular docking dynamics (MD) simulation study. Molecular study showed six probable inhibitors Mpro (Main protease), two Withania somnifera (Ashwagandha) (Withanoside V [10.32 kcal/mol] Somniferine [9.62 kcal/mol]), one Tinospora cordifolia (Giloy) (Tinocordiside [8.10 kcal/mol]) three Ocimum sanctum (Tulsi) (Vicenin [8.97 kcal/mol], Isorientin 4'-O-glucoside 2″-O-p-hydroxybenzoagte [8.55 Ursolic acid [8.52 kcal/mol]). ADMET profile prediction that best docked present work were safe possesses drug-like properties. Further MD performed assess constancy complexes found stable. Hence it could be suggested active plants potentially inhibit further equip management strategy COVID-19-a global contagion. HighlightsHolistic approach Ayurvedic avenge pandemic.Active phytoconstituents (Ashwagandha), predicted significantly hinder main protease (Mpro or 3Clpro) SARS-CoV-2.Through dynamic study, Withanoside V, Somniferine, Tinocordiside, Vicenin, anticipated impede activity Mpro.Drug-likeness compounds safe, with no toxicity.Communicated Ramaswamy H. Sarma.

Language: Английский

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Obesity: A critical risk factor in the COVID ‐19 pandemic

Clinical Obesity, Journal Year: 2020, Volume and Issue: 10(6)

Published: Aug. 28, 2020

Summary Obesity is an emerging independent risk factor for susceptibility to and severity of coronavirus disease 2019 (COVID‐19) caused by the severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2). Previous viral pandemics have shown that obesity, particularly obesity (BMI > 40 kg/m 2 ), associated with increased hospitalization, critical care admission fatalities. In this narrative review, we examine evidence influence on COVID‐19, challenges clinical management from pulmonary, endocrine immune dysfunctions in individuals identify potential areas further research. We recommend people be deemed a vulnerable group COVID‐19; trials pharmacotherapeutics, immunotherapies vaccination should prioritize inclusion obesity.

Language: Английский

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Assessing the relationship between ground levels of ozone (O3) and nitrogen dioxide (NO2) with coronavirus (COVID-19) in Milan, Italy

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 740, P. 140005 - 140005

Published: June 5, 2020

This paper investigates the correlation between high level of coronavirus SARS-CoV-2 infection accelerated transmission and lethality, surface air pollution in Milan metropolitan area, Lombardy region Italy. For January-April 2020 period, time series daily average inhalable gaseous pollutants ozone (O3) nitrogen dioxide (NO2), together climate variables (air temperature, relative humidity, wind speed, precipitation rate, atmospheric pressure field Planetary Boundary Layer) were analyzed. In spite being considered primarily transmitted by indoor bioaerosols droplets infected surfaces or direct human-to-human personal contacts, it seems that levels urban pollution, conditions have a significant impact on diffusion. Exhibited positive correlations ambient negative NO2 with increased rates COVID-19 infections (Total number, Daily New Total Deaths cases), can be attributed to airborne distribution. The results show averaged O3 temperature inversely humidity rates. Viral genome contains distinctive features, including unique N-terminal fragment within spike protein, which allows attachment pollutants. At this moment is not clear if through diffusion, presence outdoor aerosols, protein "spike" new involved infectious agent from reservoir susceptible host during highest nosocomial outbreak some agglomerated industrialized areas like is. Also, collected data for cold season (winter-early spring) when usually lower values than summer, findings study support possibility as acts virus incubator. Being novel pandemic version, might ongoing summer associated higher temperatures, low levels.

Language: Английский

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The Willingness to Receive COVID-19 Vaccine and Its Associated Factors: “Vaccination Refusal Could Prolong the War of This Pandemic” – A Systematic Review

Risk Management and Healthcare Policy, Journal Year: 2021, Volume and Issue: Volume 14, P. 2609 - 2623

Published: June 1, 2021

The outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, spreads globally, since its declaration by the World Health Organization (WHO) as a COVID-19 pandemic on March 11, 2020. vaccine is crucial preventive approach that can halt this pandemic. present systematic review was aimed to assess level willingness receive and associated factors.

Language: Английский

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