Vaccine development: Current trends and technologies

Life Sciences, Journal Year: 2023, Volume and Issue: 336, P. 122331 - 122331

Published: Dec. 7, 2023

Language: Английский

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COVID-19: Diabetes Perspective—Pathophysiology and Management

Pathogens, Journal Year: 2023, Volume and Issue: 12(2), P. 184 - 184

Published: Jan. 25, 2023

Recent evidence relating to the impact of COVID-19 on people with diabetes is limited but continues emerge. pneumonia a newly identified illness spreading rapidly throughout world and causes many disabilities fatal deaths. Over ensuing 2 years, indirect effects pandemic healthcare delivery have become prominent, along lingering virus those directly infected. Diabetes commonly risk factor that contributes not only severity mortality patients, also associated complications, including acute respiratory distress syndrome (ARDS) multi-organ failure. Diabetic patients are highly affected due increased viral entry into cells decreased immunity. Several hypotheses explain incidence infection in been proposed explained detail recently. On other hand, 20–50% reported new-onset hyperglycemia without diabetes, suggesting two-way interactions between diabetes. A systematic review required confirm as complication diagnosed COVID-19. diabetes-related complications primarily caused during SARS-CoV-2 followed by release glucocorticoids, catecholamines, pro-inflammatory cytokines, which shown drive positively. This provides brief insights potential mechanisms linking presents clinical management recommendations for better handling disease.

Language: Английский

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Prevalence of grief symptoms and disorders in the time of COVID‐19 pandemic: A meta‐analysis

International Journal of Mental Health Nursing, Journal Year: 2023, Volume and Issue: 32(3), P. 904 - 916

Published: March 7, 2023

Abstract Millions of people worldwide are mourning the loss loved ones due to COVID‐19 epidemic, which may adversely impact their mental health. This meta‐analysis aimed investigate pandemic grief symptoms and disorders for developing policy, practice, research priorities. The databases Cochrane, Embase, Ovid‐MEDLINE, WHO COVID‐19, NCBI SARS‐CoV‐2, Scopus, Web Science, CINAHL, Science Direct were comprehensively searched until July 31, 2022. Joanna Briggs Institute's Hoy's criteria used evaluate studies. A pooled prevalence was presented in a forest plot figure with corresponding 95% confidence interval (CI) prediction interval. Between‐study heterogeneity measured using I 2 Q statistics. Variations estimates different subgroups examined by moderator meta‐analysis. search identified 3677 citations, 15 studies involving 9289 participants included rate 45.1% (95%CI: 32.6%–57.5%), disorder 46.4% 37.4%–55.5%). Grief significantly higher <6 months (45.8%; 95%CI: 26.3%–65.3%) compared period more than 6 months. Unfortunately, analyses could not be performed limited problems during substantially non‐pandemic conditions; therefore, it is crucial strengthen bereavement support reduce psychological distress. results provide foundation nurses healthcare workers anticipate heightened need provision care post‐pandemic era.

Language: Английский

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Wastewater surveillance for viral pathogens: A tool for public health

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33873 - e33873

Published: June 29, 2024

A focus on water quality has intensified globally, considering its critical role in sustaining life and ecosystems. Wastewater, reflecting societal development, profoundly impacts public health. Wastewater-based epidemiology (WBE) emerged as a surveillance tool for detecting outbreaks early, monitoring infectious disease trends, providing real-time insights, particularly vulnerable communities. WBE aids tracking pathogens, including viruses, sewage, offering comprehensive understanding of community health lifestyle habits. With the rise global COVID-19 cases, gained prominence, aiding SARS-CoV-2 levels worldwide. Despite advancements treatment, poorly treated wastewater discharge remains threat, amplifying spread water-, sanitation-, hygiene (WaSH)-related diseases. WBE, serving complementary surveillance, is pivotal community-level viral infections. However, there untapped potential to expand surveillance. This review emphasizes importance link between health, highlighting need further integration into management.

Language: Английский

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S6P mutation in Delta and Omicron variant spike protein significantly enhances the efficacy of mRNA COVID-19 vaccines

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 3, 2025

The unrelenting emergence of SARS-CoV-2 variants has significantly challenged the efficacy existing COVID-19 vaccines. Enhancing stability and immunogenicity spike protein is critical for improving vaccine performance addressing variant-driven immune evasion. We developed an mRNA-based vaccine, RV-1730, encoding Delta variant with S6P mutation to enhance immunogenicity. vaccine's protective were evaluated in preclinical models, including monovalent (RV-1730) bivalent (RV-1731) formulations targeting BA.1 variants. Additionally, effectiveness RV-1730 as a heterologous booster following primary vaccination BNT162b2 (Pfizer-BioNTech) mRNA-1273 (Moderna-NIAID) was assessed. elicited stronger B T cell responses more durable neutralizing antibodies compared S2P-based RV-1731 demonstrated broad activity against emerging variants, XBB1.5 JN.1. Importantly, when used initial immunization or mRNA-1273, enhanced antibody titers multiple Omicron. Both provided superior protection indicating due mutation. incorporation into enhances strong broad-spectrum underscore their potential versatile effective strategies its evolving

Language: Английский

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