Journal of Medicinal and Chemical Sciences,
Journal Year:
2022,
Volume and Issue:
6(7)
Published: Dec. 24, 2022
Introduction:
Molybdenum
is
an
essential
trace
element
with
several
biological
functions
and
therapeutic
uses,
reported
to
have
a
cariostatic
effect
suggested
as
one
of
the
agents
that
could
be
used
alternative
fluoride
effective
ways
preventing
dental
caries.Aim:
This
study
aimed
evaluate
molybdenum
compounds
on
microhardness
enamel.Materials
Methods:
in
vitro
experimental
was
performed
50
extracted
sound
premolar
teeth.
These
teeth
were
for
orthodontic
cause.
Enamel
blocks
divided
randomly
into
five
groups.
Micro-hardness
tooth
enamel
measured
by
Vickers
test
before
after
use
different
concentrations
solutions.
ANOVA
Dunnett
t-test
(2-sided)
under
P
<
0.05.Results:
The
comparison
means
change
compound
showed
increase
number
all
solutions
significant
difference
when
compared
control
group
(p<0.000),
between
sodium
molybdate
highly
initial
final
measurements
(P<0.000).
higher
concentration
0.2%
than
0.05%
concentration.Conclusion:
Results
indicated
significantly
increased
rendering
it
more
resistant
acid
attack,
its
will
approximate
prevention
caries.
Secondary
spinal
cord
injury
(SCI)
often
causes
the
aggravation
of
inflammatory
reaction
and
nerve
injury,
which
affects
recovery
motor
function.
Bone-marrow-derived
macrophages
(BMDMs)
were
recruited
to
injured
area
after
SCI,
M1
polarization
is
key
process
for
inducing
response
neuronal
apoptosis.
We
previously
showed
that
photobiomodulation
(PBM)
can
inhibit
phenotype
BMDMs
reduce
inflammation,
but
underlying
mechanisms
are
unclear.
The
purpose
this
study
explore
potential
target
mechanism
PBM
in
treating
SCI.Transcriptome
sequencing
bioinformatics
analysis
long
noncoding
RNA
taurine
upregulated
gene
1
(lncRNA
TUG1)
was
a
PBM.
expression
specific
lncRNA
TUG1
detected
by
qPCR,
immunofluorescence,
flow
cytometry,
western
blotting,
fluorescence
situ
hybridization,
luciferase
assay.
Basso
mouse
scale
(BMS)
gait
used
evaluate
function
mice.Results
may
be
PBM,
regulating
BMDMs,
response,
axial
growth
DRG.
Mechanistically,
competed
with
TLR3
binding
miR-1192
attenuated
inhibitory
effect
on
TLR3.
This
protected
from
degradation,
enabling
high
TLR3,
promoted
activation
downstream
NF-κB
signal
release
cytokines.
In
vivo,
treatment
could
TUG1,
cytokines
survival
SCI
mice.Our
clarified
TUG1/miR-1192/TLR3
axis
an
important
pathway
macrophage
provides
theoretical
support
its
clinical
application
patients
SCI.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 8, 2024
Exosome-derived
microRNAs
(miRNAs)
are
biomacromolecules
and
nanoscale
extracellular
vesicles
originating
from
intracellular
compartments
that
secreted
by
most
cells
into
the
space.
This
review
examines
formation
function
of
exosomal
miRNAs
in
biological
information
transfer,
explores
pathogenesis
vitiligo,
highlights
relationship
between
vitiligo.
The
aim
is
to
deepen
understanding
how
influence
immune
imbalance,
oxidative
stress
damage,
melanocyte-keratinocyte
interactions,
melanogenesis
disorders
development
enhanced
may
contribute
potential
diagnostic
therapeutic
options
for
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(18), P. 9973 - 9973
Published: Sept. 16, 2024
Chemotherapy
has
been
widely
applied
in
oncotherapy.
However,
the
development
of
multidrug
resistance
(MDR)
diminished
effectiveness
anticancer
drugs
against
tumor
cells.
Such
often
results
recurrence,
metastasis,
and
patient
death.
Fortunately,
nanoparticle-based
drug
delivery
systems
provide
a
promising
strategy
by
codelivery
multiple
MDR
reversal
agents
skillful,
flexible,
smart
modification
targets.
have
demonstrated
ability
to
bypass
ABC
transporter
biological
efflux
mechanisms
due
resistance.
Hence,
how
deliver
exert
potential
antitumor
effects
successfully
explored,
applied,
developed.
Furthermore,
overcome
resistance,
developed
their
good
therapeutic
effect,
low
side
effects,
high
metastasis
inhibition.
In
view
this,
we
systematically
discuss
molecular
strategies
from
nanotherapeutics.
Finally,
summarize
intriguing
ideas
future
trends
for
further
research
overcoming
MDR.
Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
14
Published: Nov. 28, 2023
Stem
cells
have
self-renewal,
replication,
and
multidirectional
differentiation
potential,
while
progenitor
are
undifferentiated,
pluripotent
or
specialized
stem
cells.
Stem/progenitor
secrete
various
factors,
such
as
cytokines,
exosomes,
non-coding
RNAs,
proteins,
a
wide
range
of
applications
in
regenerative
medicine.
However,
therapies
based
on
their
secreted
exosomes
present
limitations,
insufficient
source
materials,
mature
differentiation,
low
transplantation
success
rates,
methods
addressing
these
problems
urgently
required.
Ultrasound
is
gaining
increasing
attention
an
emerging
technology.
Low-intensity
pulsed
ultrasound
(LIPUS)
has
mechanical,
thermal,
cavitation
effects
produces
vibrational
stimuli
that
can
lead
to
series
biochemical
changes
organs,
tissues,
cells,
the
release
extracellular
bodies,
other
signals.
These
alter
cellular
microenvironment
affect
biological
behaviors,
cell
proliferation.
Here,
we
discuss
LIPUS
functions
stem/progenitor
alterations
involved
related
pathways,
applications,
future
perspectives.
We
review
roles
mechanisms
with
aim
providing
deeper
understanding
promoting
research
development
this
field.
