None DOI Open Access

Raad Salih Al-Ani,

Mustafa Jalal Abdul-Hadi Alsaifi,

H. Abdel Kareem

et al.

Journal of Medicinal and Chemical Sciences, Journal Year: 2022, Volume and Issue: 6(7)

Published: Dec. 24, 2022

Introduction: Molybdenum is an essential trace element with several biological functions and therapeutic uses, reported to have a cariostatic effect suggested as one of the agents that could be used alternative fluoride effective ways preventing dental caries.Aim: This study aimed evaluate molybdenum compounds on microhardness enamel.Materials Methods: in vitro experimental was performed 50 extracted sound premolar teeth. These teeth were for orthodontic cause. Enamel blocks divided randomly into five groups. Micro-hardness tooth enamel measured by Vickers test before after use different concentrations solutions. ANOVA Dunnett t-test (2-sided) under P < 0.05.Results: The comparison means change compound showed increase number all solutions significant difference when compared control group (p<0.000), between sodium molybdate highly initial final measurements (P<0.000). higher concentration 0.2% than 0.05% concentration.Conclusion: Results indicated significantly increased rendering it more resistant acid attack, its will approximate prevention caries.

Language: Английский

Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis DOI Creative Commons
Cheng Ju, Yangguang Ma,

Xiaoshuang Zuo

et al.

Cellular & Molecular Biology Letters, Journal Year: 2023, Volume and Issue: 28(1)

Published: Jan. 19, 2023

Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects recovery motor function. Bone-marrow-derived macrophages (BMDMs) were recruited to injured area after SCI, M1 polarization is key process for inducing response neuronal apoptosis. We previously showed that photobiomodulation (PBM) can inhibit phenotype BMDMs reduce inflammation, but underlying mechanisms are unclear. The purpose this study explore potential target mechanism PBM in treating SCI.Transcriptome sequencing bioinformatics analysis long noncoding RNA taurine upregulated gene 1 (lncRNA TUG1) was a PBM. expression specific lncRNA TUG1 detected by qPCR, immunofluorescence, flow cytometry, western blotting, fluorescence situ hybridization, luciferase assay. Basso mouse scale (BMS) gait used evaluate function mice.Results may be PBM, regulating BMDMs, response, axial growth DRG. Mechanistically, competed with TLR3 binding miR-1192 attenuated inhibitory effect on TLR3. This protected from degradation, enabling high TLR3, promoted activation downstream NF-κB signal release cytokines. In vivo, treatment could TUG1, cytokines survival SCI mice.Our clarified TUG1/miR-1192/TLR3 axis an important pathway macrophage provides theoretical support its clinical application patients SCI.

Language: Английский

Citations

24

Exosome-derived microRNAs: emerging players in vitiligo DOI Creative Commons

Wenquan li,

Yaobin Pang,

Qingying He

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: July 8, 2024

Exosome-derived microRNAs (miRNAs) are biomacromolecules and nanoscale extracellular vesicles originating from intracellular compartments that secreted by most cells into the space. This review examines formation function of exosomal miRNAs in biological information transfer, explores pathogenesis vitiligo, highlights relationship between vitiligo. The aim is to deepen understanding how influence immune imbalance, oxidative stress damage, melanocyte-keratinocyte interactions, melanogenesis disorders development enhanced may contribute potential diagnostic therapeutic options for

Language: Английский

Citations

5

Stem Cell-Based Targeted Therapy in Pancreatic Cancer: Current approaches and future Prospects DOI

A. S. M. Mahadiuzzaman,

F.A. Dain Md Opo,

Saleh Alkarim

et al.

Tissue and Cell, Journal Year: 2024, Volume and Issue: 89, P. 102449 - 102449

Published: June 17, 2024

Language: Английский

Citations

4

The SOX gene superfamily in oncogenesis: unraveling links to ncRNAs, key pathways, chemoresistance, and gene editing approaches DOI

Ammar Yasir Ahmed,

Subasini Uthirapathy, Enwa Felix Oghenemaro

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 20, 2025

Language: Английский

Citations

0

Progress in Research of Nanotherapeutics for Overcoming Multidrug Resistance in Cancer DOI Open Access

Ayitila Maimaitijiang,

Dongze He,

Dingyang Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9973 - 9973

Published: Sept. 16, 2024

Chemotherapy has been widely applied in oncotherapy. However, the development of multidrug resistance (MDR) diminished effectiveness anticancer drugs against tumor cells. Such often results recurrence, metastasis, and patient death. Fortunately, nanoparticle-based drug delivery systems provide a promising strategy by codelivery multiple MDR reversal agents skillful, flexible, smart modification targets. have demonstrated ability to bypass ABC transporter biological efflux mechanisms due resistance. Hence, how deliver exert potential antitumor effects successfully explored, applied, developed. Furthermore, overcome resistance, developed their good therapeutic effect, low side effects, high metastasis inhibition. In view this, we systematically discuss molecular strategies from nanotherapeutics. Finally, summarize intriguing ideas future trends for further research overcoming MDR.

Language: Английский

Citations

3

Reprogramming the tumor microenvironment to improve the efficacy of cancer immunotherapies DOI Open Access

Jabar A. Faraj,

Ali Jihad Hemid Al-Athari,

Sharaf El Din Mohie

et al.

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)

Published: Sept. 29, 2022

Language: Английский

Citations

12

Small but mighty: How microRNAs drive the deadly progression of cholangiocarcinoma DOI
Abduladheem Turki Jalil, Mohanad Ali Abdulhadi,

Lubna R. Al-Ameer

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 247, P. 154565 - 154565

Published: May 21, 2023

Language: Английский

Citations

5

Development of lanthanide-based “all in one” theranostic nanoplatforms for TME-reinforced T1-weighted MRI/CT bimodal imaging DOI
Vahid Sabaghi, Parviz Rashidi Ranjbar, Fatemeh Davar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2023, Volume and Issue: 87, P. 104703 - 104703

Published: July 13, 2023

Language: Английский

Citations

5

Latest progress in low-intensity pulsed ultrasound for studying exosomes derived from stem/progenitor cells DOI Creative Commons

Yifang He,

Xia-li Wang,

Shuang-ping Deng

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Nov. 28, 2023

Stem cells have self-renewal, replication, and multidirectional differentiation potential, while progenitor are undifferentiated, pluripotent or specialized stem cells. Stem/progenitor secrete various factors, such as cytokines, exosomes, non-coding RNAs, proteins, a wide range of applications in regenerative medicine. However, therapies based on their secreted exosomes present limitations, insufficient source materials, mature differentiation, low transplantation success rates, methods addressing these problems urgently required. Ultrasound is gaining increasing attention an emerging technology. Low-intensity pulsed ultrasound (LIPUS) has mechanical, thermal, cavitation effects produces vibrational stimuli that can lead to series biochemical changes organs, tissues, cells, the release extracellular bodies, other signals. These alter cellular microenvironment affect biological behaviors, cell proliferation. Here, we discuss LIPUS functions stem/progenitor alterations involved related pathways, applications, future perspectives. We review roles mechanisms with aim providing deeper understanding promoting research development this field.

Language: Английский

Citations

5

Therapeutic targeting of dormant cancer stem cells in solid tumors DOI
Ghufran Lutfi Ismaeel, Ali Hamid AbdulHussein, Hadeel Qasim

et al.

Gene Reports, Journal Year: 2022, Volume and Issue: 30, P. 101717 - 101717

Published: Nov. 25, 2022

Language: Английский

Citations

7