Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 24, 2023
Abstract
Purpose
Oral
administration
of
the
first-line
antidepressant
paroxetine
(PAX)
has
certain
limitations,
including
difficulty
in
reaching
brain
due
to
oral
absorption.
Although
there
are
many
invasive
and
non-invasive
strategies
available
cross
blood–brain
barrier
(BBB),
they
run
counter
long-term
convenience
for
patients.
Methods
We
herein
designed
a
simple
PAX-loaded
nanoparticle-integrated
dissolving
microneedles
system
(PAX-NP-DMNs),
aiming
improve
bioavailability
PAX
through
synergistic
permeation-enhancing
effect
(MNs)
nanoparticles
(NPs).
Results
assessed
NPs
characteristics
before
after
MNs
preparation
confirmed
successful
construction
PAX-NP-DMNs
based
on
differential
scanning
calorimetry,
X-ray
diffraction,
Fourier
transform
infrared
spectroscopy.
In
mechanical
strength
test,
addition
increased
by
0.43
times
prolonged
release
from
1
h
48
h;
over
40
than
solution
isolated
skin
penetration
permeability
experiments.
Moreover,
good
biocompatibility
does
not
cause
adverse
reactions.
Conclusion
Loading
into
polylactic
glycolic
copolymer
adding
them
can
effectively
problem
MNs.
easily
penetrate
provide
rapid
painless
delivery
without
causing
effects,
thus
offering
more
convenient
effective
method
treatment
central
nervous
diseases.
Macromolecular Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 14, 2025
Abstract
Photothermal
disinfection
is
an
emerging
and
efficient
therapeutic
method
for
treating
various
infections.
However,
the
efficacy
hindered
by
poor
tissue
penetration
of
light.
While
optical
clearance
technology
can
enhance
light
transmission,
stratum
corneum
impedes
delivery
clearing
agents
to
deeper
tissues.
Herein,
dissolving
microneedle
(DMN)
patches
incorporating
photothermal
are
developed
improved
disinfection.
Such
DMN
obtained
using
sucrose
as
agent
polydopamine
(PDA)
nanoparticles
in
poly(vinyl
alcohol)
(PVA)
matrix.
After
treatment
with
composite
DMN,
transmittance
pigskin
increased
4.75
times.
The
DMNs
deliver
PDAs
subsurface
skin
while
improving
effect,
raising
temperature
45
°C
under
near‐infrared
(NIR)
irradiation
a
wavelength
808
nm.
In
deep
infection
model
(pigskin
coverage)
established
on
mouse
skin,
significantly
improve
wound
recovery
rate.
This
approach
expected
be
general
strategy
enhancing
anti‐infective
shows
great
potential
clinical
application
phototherapies.
Introduction
:
The
use
of
microneedles
for
transdermal
drug
delivery
is
rapidly
advancing,
offering
benefits
like
extended
release
and
bypassing
the
first-pass
effect.
However,
stratum
corneum
remains
a
barrier
distribution.
Microneedles
provide
painless
minimally
invasive
solution,
increasing
bioavailability.
Coated
hollow
have
shown
effectiveness,
but
dissolving
are
particularly
promising
due
to
their
easy
manufacturing,
disposability,
ability
be
made
from
therapeutic
agent
itself,
eliminating
need
additional
excipients.
Coverage
This
book
chapter
discusses
microneedle
formulations,
design,
dosage
control,
efficacy,
rate.
It
also
covers
different
types
microneedles,
designs,
fabrication
materials,
production
processes.
Clinical
trials
recent
applications
in
various
areas
highlighted.
These
include
inflammatory
skin
conditions,
scalp
issues,
cancer,
inflammation
pain
management,
diabetes,
cosmetics,
vaccine
distribution,
diagnostics,
monitoring.
presents
latest
trends
landscape,
emphasizing
evidence-based
literature,
clinical
studies.
Conclusion
To
promote
commercialization,
it
essential
establish
regulations
related
products
promptly.
potential
makes
crucial
continue
research
development
this
field.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: May 24, 2023
Abstract
Purpose
Oral
administration
of
the
first-line
antidepressant
paroxetine
(PAX)
has
certain
limitations,
including
difficulty
in
reaching
brain
due
to
oral
absorption.
Although
there
are
many
invasive
and
non-invasive
strategies
available
cross
blood–brain
barrier
(BBB),
they
run
counter
long-term
convenience
for
patients.
Methods
We
herein
designed
a
simple
PAX-loaded
nanoparticle-integrated
dissolving
microneedles
system
(PAX-NP-DMNs),
aiming
improve
bioavailability
PAX
through
synergistic
permeation-enhancing
effect
(MNs)
nanoparticles
(NPs).
Results
assessed
NPs
characteristics
before
after
MNs
preparation
confirmed
successful
construction
PAX-NP-DMNs
based
on
differential
scanning
calorimetry,
X-ray
diffraction,
Fourier
transform
infrared
spectroscopy.
In
mechanical
strength
test,
addition
increased
by
0.43
times
prolonged
release
from
1
h
48
h;
over
40
than
solution
isolated
skin
penetration
permeability
experiments.
Moreover,
good
biocompatibility
does
not
cause
adverse
reactions.
Conclusion
Loading
into
polylactic
glycolic
copolymer
adding
them
can
effectively
problem
MNs.
easily
penetrate
provide
rapid
painless
delivery
without
causing
effects,
thus
offering
more
convenient
effective
method
treatment
central
nervous
diseases.
