Journal of Fungi,
Journal Year:
2023,
Volume and Issue:
9(11), P. 1057 - 1057
Published: Oct. 27, 2023
Recent
studies
have
found
that
many
marine
microbial
polysaccharides
exhibit
distinct
immune
activity.
However,
there
is
a
relative
scarcity
of
research
on
the
immunomodulatory
activity
fungal
exopolysaccharides.
A
novel
water-soluble
exopolysaccharide
ASP-1
was
isolated
from
fermentation
broths
coral-associated
fungus
Aspergillus
pseudoglaucus
SCAU265,
and
purified
by
Diethylaminoethyl-Sepharose-52
(DEAE-52)
Fast
Flow
Sephadex
G-75.
Structural
analysis
revealed
had
an
average
molecular
weight
36.07
kDa
mainly
composed
(1→4)-linked
α-D-glucopyranosyl
residues,
along
with
highly
branched
heteropolysaccharide
regions
containing
1,4,6-glucopyranosyl,
1,3,4-glucopyranosyl,
1,4,6-galactopyranosyl,
T(terminal)-glucopyranosyl,
T-mannopyranosyl,
T-galactopyranosyl
residues.
demonstrated
significant
effects
proliferation,
nitric
oxide
levels,
secretion
cytokines
TNF-α
IL-6
in
macrophage
RAW264.7
cells.
Metabolomic
provided
insights
into
potential
mechanisms
regulation
ASP-1,
suggesting
its
involvement
regulating
function
modulating
amino
acid
anabolism,
particularly
arginine
synthesis
metabolism.
These
findings
provide
fundamental
scientific
data
for
further
accurate
mechanism
Current Research in Food Science,
Journal Year:
2024,
Volume and Issue:
9, P. 100824 - 100824
Published: Jan. 1, 2024
In
recent
years,
there
has
been
a
burgeoning
interest
in
the
utilization
of
microbial
exopolysaccharides
(EPS)
because
added
advantage
their
renewable,
biocompatible,
and
biodegradable
nature
addition
to
intended
applications.
The
endowed
properties
bacterial
EPS
make
them
valuable
candidates
for
wide
array
industrial
Modification
native
is
known
enhance
various
physico-chemical
functional
properties.
Various
modifications
such
as
physical,
chemical,
biological,
enzymatic
were
practiced
improving
bioactivity
EPS.
This
paper
comprehensively
aims
review
most
chemical
modification
techniques
employed
modify
changes
comparison
with
unmodified
forms.
Chemical
entails
strategic
alterations
structure
through
synthetic
semi-synthetic
methodologies.
Emphasis
given
antioxidant
potential
role
these
derivatives
human
health.
Antioxidant
reveal
significant
augmentation
activity
compared
counterparts.
Such
enhancement
holds
strong
promise
benefits
therapeutic
overwhelming
could
surely
encourage
application,
particularly
hydrocolloids
biomedical
contexts.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(7), P. 420 - 420
Published: July 24, 2023
As
the
largest
habitat
on
Earth,
marine
environment
harbors
various
microorganisms
of
biotechnological
potential.
Indeed,
microbial
compounds,
especially
polysaccharides
from
species,
have
been
attracting
much
attention
for
their
applications
within
medical,
pharmaceutical,
food,
and
other
industries,
with
such
interest
largely
stemming
extensive
structural
functional
diversity
displayed
by
these
natural
polymers.
At
same
time,
extreme
conditions
aquatic
ecosystem
(e.g.,
temperature,
pH,
salinity)
may
not
only
induce
to
develop
a
unique
metabolism
but
also
increase
likelihood
isolating
novel
previously
unreported
characteristics.
However,
despite
potential,
few
actually
reached
market,
even
fewer
being
origin.
Through
synthesis
relevant
literature,
this
review
seeks
provide
an
overview
polysaccharides,
including
In
particular,
suitability
specific
recent
progress
made
will
be
highlighted
before
discussing
challenges
that
currently
limit
study
as
well
potential
wider
applications.
It
is
expected
help
guide
future
research
in
field
those
In
this
report,
we
detail
the
discovery
and
characterization
of
a
new
oligosaccharide,
PCO-1,
extracted
from
culture
broth
marine
fungus
Penicillium
citrinum
SCAU-268.
The
molecular
weight
PCO-1
was
accurately
measured
to
be
1476
Da,
its
primary
structure
identified
as
α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,6)-α-D-Glcp-(1,6)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp-(1,4)-α-D-Glcp.
Our
results
demonstrate
that
markedly
elevated
secretion
cytokines
IL-6,
IL-1β,
TNF-α,
nitric
oxide
(NO)
in
concentration-dependent
fashion.
Metabolomic
studies
suggest
may
act
through
LACC1
pathway,
promoting
conversion
citrulline
ornithine
modulating
immune
responses.
conclusion,
our
study
has
successfully
elucidated
fungal-derived
oligosaccharide
confirmed
potent
immunomodulatory
activity.
Pharmacia,
Journal Year:
2025,
Volume and Issue:
72, P. 1 - 10
Published: Feb. 19, 2025
Background
:
Marine
ecosystems
are
a
vast
reservoir
of
bioactive
compounds
with
immense
pharmacological
potential.
Objectives
This
review
explores
the
molecular
mechanisms
action,
potential
therapeutic
applications,
and
challenges
in
clinical
translation
marine-derived
molecules
targeting
immune
pathways.
Methods
A
comprehensive
literature
was
conducted,
analyzing
studies
on
immunomodulatory
effects
polysaccharides,
peptides,
secondary
metabolites.
Result
In
recent
years,
derived
from
marine
organisms,
such
as
metabolites,
have
shown
promise
modulators
responses.
These
interact
pathways
to
enhance
or
suppress
functions,
making
them
valuable
for
treating
diseases
ranging
infections
autoimmune
disorders
cancer.
Conclusion
Marine-derived
exhibit
significant
agents
by
various
However,
further
research
is
required
optimize
their
applications
address
translation.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Four
novel
pyranone
derivatives
were
isolated
from
fungi
associated
with
the
marine
sponge
species
Aspergillus
versicolor.
The
planar
structures
of
these
compounds
elucidated
through
comprehensive
spectroscopic
techniques,
including
HRESIMS,
UV,
IR,
and
1D
2D
NMR.
absolute
configuration
compound
1
was
determined
via
X-ray
diffraction,
while
that
3a
using
electronic
circular
dichroism
(ECD)
spectroscopy.
Furthermore,
all
evaluated
for
their
cytotoxic
activity
against
human
lung
carcinoma
cells
(A549).
At
30
μM,
only
2
exhibited
slight
activity,
an
inhibition
rate
(46
±
3.63)%,
compared
to
doxorubicin
(positive
control,
(86
1.81)%).
In
DPPH
free
radical
scavenging
assays,
demonstrated
a
superior
capacity
than
other
derivatives,
(21.5
3.03)%
at
0.6
mg/mL,
though
still
lower
vitamin
C
((38.4
2.96)%).
Compounds
1,
3a,
3b
diminished
activities,
rates
(16.1
1.32)%,
(13.6
1.60)%,
(15.2
2.79)%,
respectively.
Journal of Functional Foods,
Journal Year:
2023,
Volume and Issue:
109, P. 105781 - 105781
Published: Sept. 16, 2023
This
study
aimed
to
explore
the
basic
structural
features
and
adjuvant
activity
of
polysaccharides
from
Portulaca
oleracea
(POP),
which
were
prepared
using
DEAE
Sephadex
A50
G
100
column
chromatography.
Its
molecular
structures
systematically
characterized
multi-chemical
spectroscopic
methods
including
colorimetry,
HPGPC-RID,
HPLC,
GC–MS,
methylation,
FT-IR,
NMR.
In
this
study,
effects
POP
evaluated
ovalbumin
(OVA)
in
mice.
And
activation
on
RAW264.7
cell
was
also
investigated.
result
showed
that
weight
8795
Da.
consisted
Man,
GlcN,
Glc,
Gal,
Ara
molar
ratio
4.94:0.56:20.55:45.47:27.61.
exerted
immunopotentiation
vitro
vivo.
significantly
activated
cells
by
promoting
production
mRNA
expression
cytokines
vitro.
Besides,
induced
phosphorylation
ERK
NF-κB
p65
cells,
indicated
macrophage
via
signaling
pathways.
not
only
dramatically
boosted
OVA-specific
IgG
antibody
its
isotype
titers,
but
triggered
Th1-
Th2-
secretion
splenocytes
immunized
mice
conclusion,
exhibited
strong
immune-enhancing
vivo
