A New Exopolysaccharide of Marine Coral-Associated Aspergillus pseudoglaucus SCAU265: Structural Characterization and Immunomodulatory Activity DOI Creative Commons
Bo Peng, Yongchun Liu, Yuqi Lin

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(11), P. 1057 - 1057

Published: Oct. 27, 2023

Recent studies have found that many marine microbial polysaccharides exhibit distinct immune activity. However, there is a relative scarcity of research on the immunomodulatory activity fungal exopolysaccharides. A novel water-soluble exopolysaccharide ASP-1 was isolated from fermentation broths coral-associated fungus Aspergillus pseudoglaucus SCAU265, and purified by Diethylaminoethyl-Sepharose-52 (DEAE-52) Fast Flow Sephadex G-75. Structural analysis revealed had an average molecular weight 36.07 kDa mainly composed (1→4)-linked α-D-glucopyranosyl residues, along with highly branched heteropolysaccharide regions containing 1,4,6-glucopyranosyl, 1,3,4-glucopyranosyl, 1,4,6-galactopyranosyl, T(terminal)-glucopyranosyl, T-mannopyranosyl, T-galactopyranosyl residues. demonstrated significant effects proliferation, nitric oxide levels, secretion cytokines TNF-α IL-6 in macrophage RAW264.7 cells. Metabolomic provided insights into potential mechanisms regulation ASP-1, suggesting its involvement regulating function modulating amino acid anabolism, particularly arginine synthesis metabolism. These findings provide fundamental scientific data for further accurate mechanism

Language: Английский

Current Status of Marine Animal Derived Polysaccharides in Sustainable Food Packaging DOI
Saurav Sarkar, Sreejan Manna, Stabak Das

et al.

ACS Food Science & Technology, Journal Year: 2023, Volume and Issue: 3(11), P. 1877 - 1889

Published: Oct. 18, 2023

The dominant use of synthetic plastic derivatives is one the major concerns across world. irrational not only causes environmental pollution but also reported to cause several health hazards. This has led researchers develop biodegradable packaging materials derived from biomaterials. Polysaccharides are abundantly available biopolymers with excellent biodegradability. Marine animals a vast source obtained polysaccharides, including chitosan, hyaluronic acid, and chondroitin sulfate. edible nature extracted marine-animal-derived polysaccharides makes it useful alternative for in food industry. In addition, antimicrobial antioxidant behavior favored its emergence as material. film forming, protective, barrier property encouraged scientists investigate them materials. easy modifiability these can improve forming ability. Article focuses on recent advancements marine animal sustainable applications.

Language: Английский

Citations

6
Dictyophora indusiata polysaccharide attenuated LPS‐induced intestinal inflammation of mice via the TLR4/JNK signaling pathway DOI
Zihao Zhang,

Zhikun Zeng,

Lin Wang

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Abstract BACKGROUND Dictyophora indusiata polysaccharide is an important bioactive component of D. , playing role in alleviating inflammation. The present study aimed to investigate the anti‐inflammatory effect and mechanism on lipopolysaccharide (LPS)‐induced intestinal inflammation mice. RESULTS Our results indicated that ameliorated mice by increasing body weight, number goblet cells decreasing inflammatory cell infiltration. In addition, significantly up‐regulated expression ZO‐1 Occuldin mRNA, which were 2.55‐fold 2.28‐fold higher than LPS group, respectively. particular, effectively inhibited Toll‐like receptor 4 (TLR4)/ c‐Jun NH2‐terminal kinase (JNK) signalling pathway was 0.34‐fold 0.49‐fold gene 0.41‐fold 0.39‐fold protein CONCLUSION suggested exerted protective effects inhibiting TLR4/JNK signaling pathway, will provide a basis for potential value as prebiotics food applications. © 2024 Society Chemical Industry.

Language: Английский

Citations

2
Effect of solid-state co-fermentation on the structural characteristics and bioactivities of polysaccharides in the medicinal residues of Gastrodia Ganoderma DOI
Lihua Chen, Zhiheng Wang,

Yuanyuan Mao

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104945 - 104945

Published: Aug. 15, 2024

Language: Английский

Citations

1
A New Exopolysaccharide of Marine Coral-Associated Aspergillus pseudoglaucus SCAU265: Structural Characterization and Immunomodulatory Activity DOI Creative Commons
Bo Peng, Yongchun Liu, Yuqi Lin

et al.

Journal of Fungi, Journal Year: 2023, Volume and Issue: 9(11), P. 1057 - 1057

Published: Oct. 27, 2023

Recent studies have found that many marine microbial polysaccharides exhibit distinct immune activity. However, there is a relative scarcity of research on the immunomodulatory activity fungal exopolysaccharides. A novel water-soluble exopolysaccharide ASP-1 was isolated from fermentation broths coral-associated fungus Aspergillus pseudoglaucus SCAU265, and purified by Diethylaminoethyl-Sepharose-52 (DEAE-52) Fast Flow Sephadex G-75. Structural analysis revealed had an average molecular weight 36.07 kDa mainly composed (1→4)-linked α-D-glucopyranosyl residues, along with highly branched heteropolysaccharide regions containing 1,4,6-glucopyranosyl, 1,3,4-glucopyranosyl, 1,4,6-galactopyranosyl, T(terminal)-glucopyranosyl, T-mannopyranosyl, T-galactopyranosyl residues. demonstrated significant effects proliferation, nitric oxide levels, secretion cytokines TNF-α IL-6 in macrophage RAW264.7 cells. Metabolomic provided insights into potential mechanisms regulation ASP-1, suggesting its involvement regulating function modulating amino acid anabolism, particularly arginine synthesis metabolism. These findings provide fundamental scientific data for further accurate mechanism

Language: Английский

Citations

0