Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 25, 2025
Alzheimer's
disease
(AD)
is
a
degenerative
of
the
central
nervous
system
characterized
by
progressive
cognitive
impairment
and
memory
loss.
Chinese
medicine's
therapeutic
effect
on
AD
has
become
promising
treatment
option
in
recent
years,
herbal
compound
Kai
Xin
San-Jia
Wei
(KXSJW)
one
its
representatives.
This
study
employed
comprehensive
approach,
including
16S
rRNA
Gaschromatography-mass
spectrometry
(GC-MS)
analysis,
to
investigate
efficacy
intrinsic
mechanism
KXSJW
AD.
50
3-month-old
APPswe/PS1dE9
transgenic
mice
were
randomly
divided
into
5
groups
(n
=
10):
model
group
(M),
donepezil
(Don),
KXSJW-low
dose
(KJW-L),
KXSJW-
medium
(KJW-M),
KXSJW-high
(KJW-H),
Ten
C57BL/6
J
wild-type
selected
as
control
(C).
The
administered
saline
gavage,
was
(0.92
mg/kg/d),
KXSJW-low/medium/high
extract
(0.9/1.8/3.6
mL/kg/d);
each
treated
once
daily
for
2
months.
Morris
Water
Maze
(MWM)
evaluate
learning
abilities.
Pathological
changes
colon
tissue
assessed
through
hematoxylin
eosin
(HE)
staining.
Analysis
gut
microbiota
conducted
using
sequencing,
microbial
metabolite
(short
chain
fatty
acids,
SCFAs)
content
detected
GC-MS.
Colonic
barrier
integrity
examined
immunohistochemistry
western
blot,
while
β-amyloid
deposition
brain
assessed.
ELISA
used
measure
serum
intestinal
peptide
hormones
(Glucagon,
GHRP-Ghrelin).
enhanced
ability
memory,
reduced
amyloid
mice.
able
restore
balance
flora
regulate
concentration
metabolites,
especially
represented
Firmicutes
major
butyric
acid.
Meanwhile,
restored
function
improved
release
level
GHRP-Ghrelin)
indicates
that
can
improve
internal
environment
may
homeostasis
AD,
with
focus
regulation
microorganisms
their
subsequently
Traditional
Medicine
(TCM)
potential
intervene
multilevel
interaction
brain-gut-axis.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Feb. 16, 2024
Abstract
The
human
gastrointestinal
tract
is
populated
with
a
diverse
microbial
community.
vast
genetic
and
metabolic
potential
of
the
gut
microbiome
underpins
its
ubiquity
in
nearly
every
aspect
biology,
including
health
maintenance,
development,
aging,
disease.
advent
new
sequencing
technologies
culture-independent
methods
has
allowed
researchers
to
move
beyond
correlative
studies
toward
mechanistic
explorations
shed
light
on
microbiome–host
interactions.
Evidence
unveiled
bidirectional
communication
between
central
nervous
system,
referred
as
“microbiota–gut–brain
axis”.
microbiota–gut–brain
axis
represents
an
important
regulator
glial
functions,
making
it
actionable
target
ameliorate
development
progression
neurodegenerative
diseases.
In
this
review,
we
discuss
mechanisms
As
provides
essential
cues
microglia,
astrocytes,
oligodendrocytes,
examine
communications
microbiota
these
cells
during
healthy
states
Subsequently,
diseases
using
metabolite-centric
approach,
while
also
examining
role
microbiota-related
neurotransmitters
hormones.
Next,
targeting
intestinal
barrier,
blood–brain
meninges,
peripheral
immune
system
counteract
dysfunction
neurodegeneration.
Finally,
conclude
by
assessing
pre-clinical
clinical
evidence
probiotics,
prebiotics,
fecal
transplantation
A
thorough
comprehension
will
foster
effective
therapeutic
interventions
for
management
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116601 - 116601
Published: May 14, 2024
Alzheimer's
disease
(AD)
comprises
a
group
of
neurodegenerative
disorders
with
some
changes
in
the
brain,
which
could
lead
to
deposition
certain
proteins
and
result
degeneration
death
brain
cells.
Patients
AD
manifest
primarily
as
cognitive
decline,
psychiatric
symptoms,
behavioural
disorders.
Short-chain
fatty
acids
(SCFAs)
are
class
saturated
(SFAs)
produced
by
gut
microorganisms
through
fermentation
dietary
fibre
ingested.
SCFAs,
significant
mediator
signalling,
can
have
diverse
physiological
pathological
roles
gut-brain
axis,
play
positive
effect
on
via
multiple
pathways.
Firstly,
differences
SCFAs
microbial
been
stated
cases
humans
mice
this
paper.
And
then,
mechanisms
three
main
treating
summarized,
well
bacteria.
Finally,
functions
played
regulating
intestinal
flora
homeostasis,
modulating
immune
system,
metabolic
were
considered
be
beneficial
for
treatment
AD,
elucidated,
key
bacteria
pointed
out.
All
all,
paper
provides
an
overview
help
people
understand
importance
axis
AD.
Molecular Neurodegeneration,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: April 16, 2024
Abstract
Trillions
of
intestinal
bacteria
in
the
human
body
undergo
dynamic
transformations
response
to
physiological
and
pathological
changes.
Alterations
their
composition
metabolites
collectively
contribute
progression
Alzheimer’s
disease.
The
role
gut
microbiota
disease
is
diverse
complex,
evidence
suggests
lipid
metabolism
may
be
one
potential
pathways.
However,
mechanisms
that
mediate
pathology
remain
unclear,
necessitating
further
investigation
for
clarification.
This
review
highlights
current
understanding
how
disrupts
discusses
implications
these
discoveries
guiding
strategies
prevention
or
treatment
based
on
existing
data.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(5), P. 4736 - 4736
Published: March 1, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
known
to
be
the
leading
cause
of
dementia
worldwide.
Many
microRNAs
(miRNAs)
were
found
deregulated
in
brain
or
blood
AD
patients,
suggesting
possible
key
role
different
stages
neurodegeneration.
In
particular,
mitogen-activated
protein
kinases
(MAPK)
signaling
can
impaired
by
miRNA
dysregulation
during
AD.
Indeed,
aberrant
MAPK
pathway
may
facilitate
development
amyloid-beta
(Aβ)
and
Tau
pathology,
oxidative
stress,
neuroinflammation,
cell
death.
The
aim
this
review
was
describe
molecular
interactions
between
miRNAs
MAPKs
pathogenesis
selecting
evidence
from
experimental
models.
Publications
ranging
2010
2023
considered,
based
on
PubMed
Web
Science
databases.
According
obtained
data,
several
deregulations
regulate
conversely.
Moreover,
overexpressing
silencing
involved
regulation
seen
improve
cognitive
deficits
animal
miR-132
particular
interest
due
its
neuroprotective
functions
inhibiting
Aβ
depositions,
as
well
through
ERK/MAPK1
modulation.
However,
further
investigations
are
required
confirm
implement
these
promising
results.
