A highly selective and sensitive ICT-based Cu2+ fluorescent probe and its application in bioimaging

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 262, P. 115127 - 115127

Published: June 13, 2023

Cu2+ is an essential trace element for the organism, but its excess can also cause irreversible damage to organism. As such, a "Turn-Off" fluorescent probe DPAP specific detection of was successfully constructed. exhibits large Stokes shift (120 nm), fast reaction speed (1 min), low limit (15.2 nM), toxicity, and good cell permeability. quenches fluorescence by blocking intramolecular charge transfer process achieve has been confirmed HRMS, 1H NMR DFT calculations. Excitingly, five-cycle successful recovery in environmental water samples fully demonstrate potential practical applications. In particular, observe distribution translocation patterns exogenous HeLa cells zebrafish real-time. This research concept offered important theoretical support study behavior heavy metal ions.

Language: Английский

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A novel Zn2+-coordination fluorescence probe for sensing HPPD inhibitors and its application in environmental media and biological imaging

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 273, P. 116144 - 116144

Published: Feb. 26, 2024

Mesotrione, topramezone, tembotrione, and sulcotrione are four types of 4-hydroxyphenylpyruvate dioxidase (HPPD) inhibitor herbicides that extensively employed in agricultural practices, but their usage also leads to environmental pollution poses risks human health. A probe (E)-1-((2-(pyridin-2-yl) hydrazineylidene) methyl) naphthalen-2-ol (CHMN) based on chelation enhancement (CHEF) effect synthesized. CHMN was first chelated with Zn

Language: Английский

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Development of a Coumarin-Based Schiff Base Fluorescent Probe and its Application in Detection of Cu²⁺

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Language: Английский

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A novel Cu2+-coordinated fluorescent sensing system for specific detection of glyphosate and its applications in environmental and biological systems

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137424 - 137424

Published: Jan. 1, 2025

Language: Английский

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A novel “Turn-Off-On” fluorescent probe for specific sequential detection of Cu2+ and glyphosate and its application in biological imaging

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 317, P. 124420 - 124420

Published: May 7, 2024

Language: Английский

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Exploration of the intermolecular isoproturon–bovine serum albumin combination: Biophysical and computational prospects

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: 450, P. 115464 - 115464

Published: Jan. 10, 2024

Language: Английский

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Influence of para-substituted benzaldehyde derivatives with different push/pull electron strength groups on the conformation of human serum albumin and toxicological effects in zebrafish

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 266, P. 131246 - 131246

Published: March 28, 2024

Language: Английский

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Binding divergence of polystyrene nanoparticles with serum albumin caused by surface functionalization

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 903, P. 166578 - 166578

Published: Aug. 25, 2023

Language: Английский

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In-lab synthesized turn-off fluorescence sensor for estimation of Gemigliptin and Rosuvastatin polypill appraised by Spider diagram, AGREE and whiteness metrics

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Feb. 5, 2024

Abstract Gemigliptin-Rosuvastatin single-pill combination is a promising therapeutic tool in the effective control of hyperglycemia and hypercholesterolemia. Organic sensors with high quantum yields have profoundly significant applications pharmaceutical industry, such as routine quality marketed formulations. Herein, fluorescence sensor, 2-Morpholino-4,6-dimethyl nicotinonitrile 3 , (λex; 226 nm, λem; 406 nm), was synthesized yield 56.86% fully characterized our laboratory. This sensor showed efficiency for determination Gemigliptin (GEM) Rosuvastatin (RSV) traces through their stoichiometric interactions simultaneously fractionated by selective solvation. The interaction between stated analytes quenching effect. Various experimental parameters turn-off mechanism were addressed. adopted approach fulfilled ICH validation criteria linear satisfactory ranges, 0.2–2 0.1–1 μg/mL GEM RSV, respectively nano-limits detection less than 30 ng/mL both analytes. has been successfully applied RSV co-assessment synthetic polypill excellent % recoveries 98.83 ± 0.86 100.19 0.64, respectively. No statistically difference results proposed reported spectrophotometric methods terms F - t -tests. Ecological whiteness appraisals study conducted via three novel approaches: Greenness Index Spider Diagram, Analytical Metric, Red–Green–Blue 12 model. aforementioned metrics proved superiority over previously published one regarding eco-friendliness sustainability. Our devised fluorimetric sensing method sensitivity, selectivity, feasibility, rapidity minimal cost environmental burden other sophisticated techniques, making it reliable labs.

Language: Английский

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Enantioselective effects of chiral profenofos on the conformation for human serum albumin

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 205, P. 106159 - 106159

Published: Sept. 30, 2024

Language: Английский

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